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Combined effects of physical activity, dietary isoflavones and 17beta-estradiol on movement drive, body weight and bone mineral density in ovariectomized female rats.
Planta Med 2006; 72(6):484-7PM

Abstract

Reduced estrogen levels occurring during menopause in woman are accompanied by a variety of disorders, e. g., hot flushes, depressions, osteoporosis, increase of body weight, and reduced movement drive. In this study we investigated the combined effects of physical activity, estradiol substitution, and a phytoestrogen-rich diet on bone mineral density, increase of body weight, and movement drive in an animal model. Ovariectomized (OVX) female Wistar rats were either fed an isoflavone-rich diet (IRD) or substituted with 17beta-estradiol (E2) for 3 months. Sham-operated rats (Sham) and vehicle-treated OVX animals served as controls. One half of the animals had the opportunity of voluntary wheel running. OVX rats displayed an eight times lower movement activity than Sham animals. E2 treatment, but not IRD, significantly increased the movement activity of OVX rats. During 3 months the lowest increase of body weight was observed in Sham animals, the highest rate in OVX animals. Along with running activity E2 treatment, but not IRD, also lowered the increase of body weight significantly compared to OVX animals. Bone mineral density (BMD) in the trabecular area of the tibia was strongly reduced in OVX rats compared to Sham animals. In contrast to IRD, E2 substitution resulted in a protection of BMD in this area compared to OVX animals. Our data demonstrate that body weight, movement drive, and BMD are positively influenced by E2. The steroid estrogen acts in the trabecular area of the tibia in a bone-protective manner, increases movement drive and antagonizes the increase of body weight. All these effects could not be observed in animals fed an isoflavone-rich diet.

Authors+Show Affiliations

Institut für Kreislaufforschung und Sportmedizin, Abt. Molekulare und Zelluläre Sportmedizin, Deutsche Sporthochschule Köln, Köln, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16773530

Citation

Hertrampf, Torsten, et al. "Combined Effects of Physical Activity, Dietary Isoflavones and 17beta-estradiol On Movement Drive, Body Weight and Bone Mineral Density in Ovariectomized Female Rats." Planta Medica, vol. 72, no. 6, 2006, pp. 484-7.
Hertrampf T, Degen GH, Kaid AA, et al. Combined effects of physical activity, dietary isoflavones and 17beta-estradiol on movement drive, body weight and bone mineral density in ovariectomized female rats. Planta Med. 2006;72(6):484-7.
Hertrampf, T., Degen, G. H., Kaid, A. A., Laudenbach-Leschowsky, U., Seibel, J., Di Virgilio, A. L., & Diel, P. (2006). Combined effects of physical activity, dietary isoflavones and 17beta-estradiol on movement drive, body weight and bone mineral density in ovariectomized female rats. Planta Medica, 72(6), pp. 484-7.
Hertrampf T, et al. Combined Effects of Physical Activity, Dietary Isoflavones and 17beta-estradiol On Movement Drive, Body Weight and Bone Mineral Density in Ovariectomized Female Rats. Planta Med. 2006;72(6):484-7. PubMed PMID: 16773530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined effects of physical activity, dietary isoflavones and 17beta-estradiol on movement drive, body weight and bone mineral density in ovariectomized female rats. AU - Hertrampf,Torsten, AU - Degen,Gisela H, AU - Kaid,Abdel Ait, AU - Laudenbach-Leschowsky,Ute, AU - Seibel,Jan, AU - Di Virgilio,Ana Laura, AU - Diel,Patrick, PY - 2006/6/15/pubmed PY - 2006/7/25/medline PY - 2006/6/15/entrez SP - 484 EP - 7 JF - Planta medica JO - Planta Med. VL - 72 IS - 6 N2 - Reduced estrogen levels occurring during menopause in woman are accompanied by a variety of disorders, e. g., hot flushes, depressions, osteoporosis, increase of body weight, and reduced movement drive. In this study we investigated the combined effects of physical activity, estradiol substitution, and a phytoestrogen-rich diet on bone mineral density, increase of body weight, and movement drive in an animal model. Ovariectomized (OVX) female Wistar rats were either fed an isoflavone-rich diet (IRD) or substituted with 17beta-estradiol (E2) for 3 months. Sham-operated rats (Sham) and vehicle-treated OVX animals served as controls. One half of the animals had the opportunity of voluntary wheel running. OVX rats displayed an eight times lower movement activity than Sham animals. E2 treatment, but not IRD, significantly increased the movement activity of OVX rats. During 3 months the lowest increase of body weight was observed in Sham animals, the highest rate in OVX animals. Along with running activity E2 treatment, but not IRD, also lowered the increase of body weight significantly compared to OVX animals. Bone mineral density (BMD) in the trabecular area of the tibia was strongly reduced in OVX rats compared to Sham animals. In contrast to IRD, E2 substitution resulted in a protection of BMD in this area compared to OVX animals. Our data demonstrate that body weight, movement drive, and BMD are positively influenced by E2. The steroid estrogen acts in the trabecular area of the tibia in a bone-protective manner, increases movement drive and antagonizes the increase of body weight. All these effects could not be observed in animals fed an isoflavone-rich diet. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/16773530/Combined_effects_of_physical_activity_dietary_isoflavones_and_17beta_estradiol_on_movement_drive_body_weight_and_bone_mineral_density_in_ovariectomized_female_rats_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2006-931579 DB - PRIME DP - Unbound Medicine ER -