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Chemical exposures and Parkinson's disease: a population-based case-control study.
Mov Disord. 2006 Oct; 21(10):1688-92.MD

Abstract

The putative association between pesticide exposures and Parkinson's disease (PD) remains controversial. We identified all subjects who developed PD in Olmsted County, Minnesota, from 1976 through 1995, and matched them by age (+/- 1 year) and sex to general population controls. We assessed exposures to chemical products by means of telephone interview with cases, controls, or their proxies (149 cases; 129 controls). Exposure to pesticides related or unrelated to farming was associated with PD in men (odds ratio, 2.4; 95% confidence interval, 1.1-5.4; P = 0.04). The association remained significant after adjustment for education or smoking. Analyses for the other six categories of industrial and household chemicals were all nonsignificant. This population-based study suggests a link between pesticides use and PD that is restricted to men. Pesticides may interact with other genetic or nongenetic factors that are different in men and women.

Authors+Show Affiliations

Division of Epidemiology, Department of Health Sciences Research, Mayo College of Medicine, Rochester, Minnesota 55905, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16773614

Citation

Frigerio, Roberta, et al. "Chemical Exposures and Parkinson's Disease: a Population-based Case-control Study." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 21, no. 10, 2006, pp. 1688-92.
Frigerio R, Sanft KR, Grossardt BR, et al. Chemical exposures and Parkinson's disease: a population-based case-control study. Mov Disord. 2006;21(10):1688-92.
Frigerio, R., Sanft, K. R., Grossardt, B. R., Peterson, B. J., Elbaz, A., Bower, J. H., Ahlskog, J. E., de Andrade, M., Maraganore, D. M., & Rocca, W. A. (2006). Chemical exposures and Parkinson's disease: a population-based case-control study. Movement Disorders : Official Journal of the Movement Disorder Society, 21(10), 1688-92.
Frigerio R, et al. Chemical Exposures and Parkinson's Disease: a Population-based Case-control Study. Mov Disord. 2006;21(10):1688-92. PubMed PMID: 16773614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical exposures and Parkinson's disease: a population-based case-control study. AU - Frigerio,Roberta, AU - Sanft,Kevin R, AU - Grossardt,Brandon R, AU - Peterson,Brett J, AU - Elbaz,Alexis, AU - Bower,James H, AU - Ahlskog,J Eric, AU - de Andrade,Mariza, AU - Maraganore,Demetrius M, AU - Rocca,Walter A, PY - 2006/6/15/pubmed PY - 2007/2/3/medline PY - 2006/6/15/entrez SP - 1688 EP - 92 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 21 IS - 10 N2 - The putative association between pesticide exposures and Parkinson's disease (PD) remains controversial. We identified all subjects who developed PD in Olmsted County, Minnesota, from 1976 through 1995, and matched them by age (+/- 1 year) and sex to general population controls. We assessed exposures to chemical products by means of telephone interview with cases, controls, or their proxies (149 cases; 129 controls). Exposure to pesticides related or unrelated to farming was associated with PD in men (odds ratio, 2.4; 95% confidence interval, 1.1-5.4; P = 0.04). The association remained significant after adjustment for education or smoking. Analyses for the other six categories of industrial and household chemicals were all nonsignificant. This population-based study suggests a link between pesticides use and PD that is restricted to men. Pesticides may interact with other genetic or nongenetic factors that are different in men and women. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/16773614/Chemical_exposures_and_Parkinson's_disease:_a_population_based_case_control_study_ DB - PRIME DP - Unbound Medicine ER -