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Excessive daytime sleepiness in patients with Parkinson's disease: a polysomnography study.
Mov Disord. 2006 Sep; 21(9):1432-8.MD

Abstract

To investigate excessive daytime sleepiness (EDS) in patients with Parkinson's disease (PD), the reasons for which have not yet been clarified, polysomnography (PSG) and the Multiple Sleep Latency Test (MSLT) were performed in 46 patients with PD, and, in addition, PSG was performed in 30 healthy controls. Assessment included Epworth Sleepiness Score (ESS), Mini-Mental State Examination (MMSE), and Hamilton Test (HT) for depression. Fifty percent of PD patients reported EDS (ESS, 10 +/- 4.5 vs. 6.9 +/- 3.7; P = 0.01). Compared with controls, PD patients as a group had lower sleep efficiency (65 +/- 22 vs. 77 +/- 14; P = 0.03), a longer Stage 2 (73 +/- 12 vs. 67 +/- 12; P = 0.03), and a shorter rapid eye movement stage (8 +/- 8 vs. 17 +/- 8; P < 0.001). Clinical data and sleep characteristics were similar in PD with/without EDS. Of interest, patients treated with clonazepam (CLNZ) had lower EDS than those without CLNZ (ESS, 7.9 +/- 4.7 vs. 11.3 +/- 4.0; P = 0.03). These patients suffered less periodic leg movement during sleep (2.1 +/- 2.7 vs. 12.4 +/- 28; P = 0.04), which might explain the finding. No correlation was found between ESS, MSLT, and all other clinical features analyzed. In PD patients, according to the data obtained, severity of EDS does not depend on any specific clinical factor and the etiology is probably multifactorial. Paradoxically, PD patients treated with CLNZ were less sleepy than patients not treated with CLNZ.

Authors+Show Affiliations

Sleep Laboratory, Assaf Harofeh Medical Center, Zerifin, Israel, affiliated to Sackler School of Medicine, Tel Aviv University, Israel. i_shpirer@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16773617

Citation

Shpirer, Isaac, et al. "Excessive Daytime Sleepiness in Patients With Parkinson's Disease: a Polysomnography Study." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 21, no. 9, 2006, pp. 1432-8.
Shpirer I, Miniovitz A, Klein C, et al. Excessive daytime sleepiness in patients with Parkinson's disease: a polysomnography study. Mov Disord. 2006;21(9):1432-8.
Shpirer, I., Miniovitz, A., Klein, C., Goldstein, R., Prokhorov, T., Theitler, J., Pollak, L., & Rabey, J. M. (2006). Excessive daytime sleepiness in patients with Parkinson's disease: a polysomnography study. Movement Disorders : Official Journal of the Movement Disorder Society, 21(9), 1432-8.
Shpirer I, et al. Excessive Daytime Sleepiness in Patients With Parkinson's Disease: a Polysomnography Study. Mov Disord. 2006;21(9):1432-8. PubMed PMID: 16773617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Excessive daytime sleepiness in patients with Parkinson's disease: a polysomnography study. AU - Shpirer,Isaac, AU - Miniovitz,Ala, AU - Klein,Colin, AU - Goldstein,Richard, AU - Prokhorov,Tatiana, AU - Theitler,Jack, AU - Pollak,Lea, AU - Rabey,Jose Martin, PY - 2006/6/15/pubmed PY - 2007/2/3/medline PY - 2006/6/15/entrez SP - 1432 EP - 8 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 21 IS - 9 N2 - To investigate excessive daytime sleepiness (EDS) in patients with Parkinson's disease (PD), the reasons for which have not yet been clarified, polysomnography (PSG) and the Multiple Sleep Latency Test (MSLT) were performed in 46 patients with PD, and, in addition, PSG was performed in 30 healthy controls. Assessment included Epworth Sleepiness Score (ESS), Mini-Mental State Examination (MMSE), and Hamilton Test (HT) for depression. Fifty percent of PD patients reported EDS (ESS, 10 +/- 4.5 vs. 6.9 +/- 3.7; P = 0.01). Compared with controls, PD patients as a group had lower sleep efficiency (65 +/- 22 vs. 77 +/- 14; P = 0.03), a longer Stage 2 (73 +/- 12 vs. 67 +/- 12; P = 0.03), and a shorter rapid eye movement stage (8 +/- 8 vs. 17 +/- 8; P < 0.001). Clinical data and sleep characteristics were similar in PD with/without EDS. Of interest, patients treated with clonazepam (CLNZ) had lower EDS than those without CLNZ (ESS, 7.9 +/- 4.7 vs. 11.3 +/- 4.0; P = 0.03). These patients suffered less periodic leg movement during sleep (2.1 +/- 2.7 vs. 12.4 +/- 28; P = 0.04), which might explain the finding. No correlation was found between ESS, MSLT, and all other clinical features analyzed. In PD patients, according to the data obtained, severity of EDS does not depend on any specific clinical factor and the etiology is probably multifactorial. Paradoxically, PD patients treated with CLNZ were less sleepy than patients not treated with CLNZ. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/16773617/Excessive_daytime_sleepiness_in_patients_with_Parkinson's_disease:_a_polysomnography_study_ L2 - https://doi.org/10.1002/mds.21002 DB - PRIME DP - Unbound Medicine ER -