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Special low-protein foods ameliorate postprandial off in patients with advanced Parkinson's disease.
Mov Disord. 2006 Oct; 21(10):1682-7.MD

Abstract

Protein intake interferes with levodopa therapy. Patients with advanced Parkinson's disease (PD) should restrict daily protein intake and shift protein intake to the evening. For further reduction of protein intake in the first part of the day, special low-protein products (LPP) should be used instead of normal food products at breakfast and lunch. We studied the efficacy of LPP on postprandial off periods, in PD patients on levodopa therapy. The methods included a randomized, cross-over, single-blind, pilot clinical trial comparing a 2-month balanced diet with a 2-month LPP diet in 18 PD patients with motor fluctuations. The off phases were significantly shorter after LPP diet than after balanced diet (postprandial off, 49 +/- 73 min vs. 79 +/- 72 min and total off, 164 +/- 148 min vs. 271 +/- 174 min, both P < 0.0001). Moreover, a reduction in total off time during LPP diet (3.3 +/- 2.7 hr vs. 4.7 +/- 3.3 hr, P < 0.0001), occurred also in the 9 patients who did not experience subjective benefit. No significant changes in hematological and biochemical variables or body composition were recorded; a slight reduction in body weight (mean, -1.8%) was observed. Consumption of LPP in the first part of the day ameliorates off periods in PD patients, but additional studies including pharmacokinetics are needed.

Authors+Show Affiliations

Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy. barichella@parkinson.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16773618

Citation

Barichella, Michela, et al. "Special Low-protein Foods Ameliorate Postprandial Off in Patients With Advanced Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 21, no. 10, 2006, pp. 1682-7.
Barichella M, Marczewska A, De Notaris R, et al. Special low-protein foods ameliorate postprandial off in patients with advanced Parkinson's disease. Mov Disord. 2006;21(10):1682-7.
Barichella, M., Marczewska, A., De Notaris, R., Vairo, A., Baldo, C., Mauri, A., Savardi, C., & Pezzoli, G. (2006). Special low-protein foods ameliorate postprandial off in patients with advanced Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 21(10), 1682-7.
Barichella M, et al. Special Low-protein Foods Ameliorate Postprandial Off in Patients With Advanced Parkinson's Disease. Mov Disord. 2006;21(10):1682-7. PubMed PMID: 16773618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Special low-protein foods ameliorate postprandial off in patients with advanced Parkinson's disease. AU - Barichella,Michela, AU - Marczewska,Agnieszka, AU - De Notaris,Roberta, AU - Vairo,Antonella, AU - Baldo,Cinzia, AU - Mauri,Andrea, AU - Savardi,Chiara, AU - Pezzoli,Gianni, PY - 2006/6/15/pubmed PY - 2007/2/3/medline PY - 2006/6/15/entrez SP - 1682 EP - 7 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 21 IS - 10 N2 - Protein intake interferes with levodopa therapy. Patients with advanced Parkinson's disease (PD) should restrict daily protein intake and shift protein intake to the evening. For further reduction of protein intake in the first part of the day, special low-protein products (LPP) should be used instead of normal food products at breakfast and lunch. We studied the efficacy of LPP on postprandial off periods, in PD patients on levodopa therapy. The methods included a randomized, cross-over, single-blind, pilot clinical trial comparing a 2-month balanced diet with a 2-month LPP diet in 18 PD patients with motor fluctuations. The off phases were significantly shorter after LPP diet than after balanced diet (postprandial off, 49 +/- 73 min vs. 79 +/- 72 min and total off, 164 +/- 148 min vs. 271 +/- 174 min, both P < 0.0001). Moreover, a reduction in total off time during LPP diet (3.3 +/- 2.7 hr vs. 4.7 +/- 3.3 hr, P < 0.0001), occurred also in the 9 patients who did not experience subjective benefit. No significant changes in hematological and biochemical variables or body composition were recorded; a slight reduction in body weight (mean, -1.8%) was observed. Consumption of LPP in the first part of the day ameliorates off periods in PD patients, but additional studies including pharmacokinetics are needed. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/16773618/Special_low_protein_foods_ameliorate_postprandial_off_in_patients_with_advanced_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.21003 DB - PRIME DP - Unbound Medicine ER -