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The 32-base pair deletion of the chemokine receptor 5 gene (CCR5-Delta32) is not associated with primary sclerosing cholangitis in 363 Scandinavian patients.
Tissue Antigens. 2006 Jul; 68(1):78-81.TA

Abstract

CCR5 is a chemokine receptor expressed on T-cells and macrophages. A 32-base pair deletion in the chemokine receptor 5 gene (CCR5-Delta32) leads to a non-functional receptor. Conflicting evidence exists whether this deletion is associated with primary sclerosing cholangitis (PSC). We genotyped the CCR5-Delta32 variant in 363 PSC patients and 366 controls. No significant increase in the Delta32 allele frequency was detected in the PSC patients compared to controls (12.7% vs 10.7% OR = 1.22, 95% CI [0.88, 1.68], P = 0.23). Survival analysis did not reveal any significant effects from CCR5-Delta32 genotypes on disease progression. Thus, in this study (power > 90%, given OR = 2, alpha = 0.05), we were unable to replicate previous findings and our results do not support an involvement of CCR5-Delta32 in either PSC susceptibility or progression.

Authors+Show Affiliations

Institute of Immunology, Rikshospitalet University Hospital, Sognsvannsyn 20, 0027 Oslo, Norway.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16774544

Citation

Melum, E, et al. "The 32-base Pair Deletion of the Chemokine Receptor 5 Gene (CCR5-Delta32) Is Not Associated With Primary Sclerosing Cholangitis in 363 Scandinavian Patients." Tissue Antigens, vol. 68, no. 1, 2006, pp. 78-81.
Melum E, Karlsen TH, Broomé U, et al. The 32-base pair deletion of the chemokine receptor 5 gene (CCR5-Delta32) is not associated with primary sclerosing cholangitis in 363 Scandinavian patients. Tissue Antigens. 2006;68(1):78-81.
Melum, E., Karlsen, T. H., Broomé, U., Thorsby, E., Schrumpf, E., Boberg, K. M., & Lie, B. A. (2006). The 32-base pair deletion of the chemokine receptor 5 gene (CCR5-Delta32) is not associated with primary sclerosing cholangitis in 363 Scandinavian patients. Tissue Antigens, 68(1), 78-81.
Melum E, et al. The 32-base Pair Deletion of the Chemokine Receptor 5 Gene (CCR5-Delta32) Is Not Associated With Primary Sclerosing Cholangitis in 363 Scandinavian Patients. Tissue Antigens. 2006;68(1):78-81. PubMed PMID: 16774544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The 32-base pair deletion of the chemokine receptor 5 gene (CCR5-Delta32) is not associated with primary sclerosing cholangitis in 363 Scandinavian patients. AU - Melum,E, AU - Karlsen,T H, AU - Broomé,U, AU - Thorsby,E, AU - Schrumpf,E, AU - Boberg,K M, AU - Lie,B A, PY - 2006/6/16/pubmed PY - 2006/8/26/medline PY - 2006/6/16/entrez SP - 78 EP - 81 JF - Tissue antigens JO - Tissue Antigens VL - 68 IS - 1 N2 - CCR5 is a chemokine receptor expressed on T-cells and macrophages. A 32-base pair deletion in the chemokine receptor 5 gene (CCR5-Delta32) leads to a non-functional receptor. Conflicting evidence exists whether this deletion is associated with primary sclerosing cholangitis (PSC). We genotyped the CCR5-Delta32 variant in 363 PSC patients and 366 controls. No significant increase in the Delta32 allele frequency was detected in the PSC patients compared to controls (12.7% vs 10.7% OR = 1.22, 95% CI [0.88, 1.68], P = 0.23). Survival analysis did not reveal any significant effects from CCR5-Delta32 genotypes on disease progression. Thus, in this study (power > 90%, given OR = 2, alpha = 0.05), we were unable to replicate previous findings and our results do not support an involvement of CCR5-Delta32 in either PSC susceptibility or progression. SN - 0001-2815 UR - https://www.unboundmedicine.com/medline/citation/16774544/The_32_base_pair_deletion_of_the_chemokine_receptor_5_gene__CCR5_Delta32__is_not_associated_with_primary_sclerosing_cholangitis_in_363_Scandinavian_patients_ L2 - https://doi.org/10.1111/j.1399-0039.2006.00604.x DB - PRIME DP - Unbound Medicine ER -