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Closing the loop: combining insulin pumps and glucose sensors in children with type 1 diabetes mellitus.
Pediatr Diabetes. 2006 Aug; 7 Suppl 4:45-9.PD

Abstract

Tight glycemic control of diabetic patients is associated with a reduction in the risk of microvascular and macrovascular complications, yet with elevated risk of severe episodes of hypoglycemia. The goal of "closing the loop" is to develop an autonomous insulin delivery system attached to a device capable of continuous glucose sensing, thus mimicking the islet beta cells activity and its capability of maintaining normal blood glucose levels and freeing the patient from the need of constant calculations of daily insulin and carbohydrates. The closed loop will protect patients from experiencing glucose excursions, including life-threatening events of hypoglycemia, thus improving glycemic control, reducing the fear from hypoglycemia and improving patients' quality of life. This review focuses on the steps towards closing the loop in the attempts to develop an artificial pancreas and on recent ongoing research and future directions in this field.

Authors+Show Affiliations

Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16774618

Citation

Shalitin, Shlomit, and Moshe Phillip. "Closing the Loop: Combining Insulin Pumps and Glucose Sensors in Children With Type 1 Diabetes Mellitus." Pediatric Diabetes, vol. 7 Suppl 4, 2006, pp. 45-9.
Shalitin S, Phillip M. Closing the loop: combining insulin pumps and glucose sensors in children with type 1 diabetes mellitus. Pediatr Diabetes. 2006;7 Suppl 4:45-9.
Shalitin, S., & Phillip, M. (2006). Closing the loop: combining insulin pumps and glucose sensors in children with type 1 diabetes mellitus. Pediatric Diabetes, 7 Suppl 4, 45-9.
Shalitin S, Phillip M. Closing the Loop: Combining Insulin Pumps and Glucose Sensors in Children With Type 1 Diabetes Mellitus. Pediatr Diabetes. 2006;7 Suppl 4:45-9. PubMed PMID: 16774618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Closing the loop: combining insulin pumps and glucose sensors in children with type 1 diabetes mellitus. AU - Shalitin,Shlomit, AU - Phillip,Moshe, PY - 2006/6/16/pubmed PY - 2006/12/9/medline PY - 2006/6/16/entrez SP - 45 EP - 9 JF - Pediatric diabetes JO - Pediatr Diabetes VL - 7 Suppl 4 N2 - Tight glycemic control of diabetic patients is associated with a reduction in the risk of microvascular and macrovascular complications, yet with elevated risk of severe episodes of hypoglycemia. The goal of "closing the loop" is to develop an autonomous insulin delivery system attached to a device capable of continuous glucose sensing, thus mimicking the islet beta cells activity and its capability of maintaining normal blood glucose levels and freeing the patient from the need of constant calculations of daily insulin and carbohydrates. The closed loop will protect patients from experiencing glucose excursions, including life-threatening events of hypoglycemia, thus improving glycemic control, reducing the fear from hypoglycemia and improving patients' quality of life. This review focuses on the steps towards closing the loop in the attempts to develop an artificial pancreas and on recent ongoing research and future directions in this field. SN - 1399-543X UR - https://www.unboundmedicine.com/medline/citation/16774618/Closing_the_loop:_combining_insulin_pumps_and_glucose_sensors_in_children_with_type_1_diabetes_mellitus_ L2 - https://doi.org/10.1111/j.1399-543X.2006.00170.x DB - PRIME DP - Unbound Medicine ER -