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Prevalence of Toxoplasma infection in first-episode schizophrenia and comparison between Toxoplasma-seropositive and Toxoplasma-seronegative schizophrenia.
Acta Psychiatr Scand 2006; 114(1):40-8AP

Abstract

OBJECTIVE

To compare the prevalence of Toxoplasma infection between the first-episode schizophrenia and the controls and to compare the clinical features between the Toxoplasma-seronegative and Toxoplasma-seropositive patients with schizophrenia.

METHOD

The rate of serum reactivity to Toxoplasma in 600 schizophrenia, 600 affective disorders, and 400 controls was investigated. The clinical symptoms of the schizophrenia patients were scored and compared.

RESULTS

The rate of IgG antibody, not IgM in the schizophrenia patients, was higher than the control groups, and the odds ratio of schizophrenia associated with IgG antibody was 2.22-5.12. The affective disorders did not differ in the rate of IgG or IgM antibody from the normal or the physical disease control. The seropositive schizophrenia patients had higher scores on the positive subscale and three components of Positive and Negative Symptoms Scale than the seronegative patients.

CONCLUSION

This study lent further weight to the hypothesis that exposure to Toxoplasma may be a risk factor for schizophrenia.

Authors+Show Affiliations

Department of Psychiatry, Research Institute of Neurology and Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16774660

Citation

Wang, H-L, et al. "Prevalence of Toxoplasma Infection in First-episode Schizophrenia and Comparison Between Toxoplasma-seropositive and Toxoplasma-seronegative Schizophrenia." Acta Psychiatrica Scandinavica, vol. 114, no. 1, 2006, pp. 40-8.
Wang HL, Wang GH, Li QY, et al. Prevalence of Toxoplasma infection in first-episode schizophrenia and comparison between Toxoplasma-seropositive and Toxoplasma-seronegative schizophrenia. Acta Psychiatr Scand. 2006;114(1):40-8.
Wang, H. L., Wang, G. H., Li, Q. Y., Shu, C., Jiang, M. S., & Guo, Y. (2006). Prevalence of Toxoplasma infection in first-episode schizophrenia and comparison between Toxoplasma-seropositive and Toxoplasma-seronegative schizophrenia. Acta Psychiatrica Scandinavica, 114(1), pp. 40-8.
Wang HL, et al. Prevalence of Toxoplasma Infection in First-episode Schizophrenia and Comparison Between Toxoplasma-seropositive and Toxoplasma-seronegative Schizophrenia. Acta Psychiatr Scand. 2006;114(1):40-8. PubMed PMID: 16774660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of Toxoplasma infection in first-episode schizophrenia and comparison between Toxoplasma-seropositive and Toxoplasma-seronegative schizophrenia. AU - Wang,H-L, AU - Wang,G-H, AU - Li,Q-Y, AU - Shu,C, AU - Jiang,M-S, AU - Guo,Y, PY - 2006/6/16/pubmed PY - 2007/7/3/medline PY - 2006/6/16/entrez SP - 40 EP - 8 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 114 IS - 1 N2 - OBJECTIVE: To compare the prevalence of Toxoplasma infection between the first-episode schizophrenia and the controls and to compare the clinical features between the Toxoplasma-seronegative and Toxoplasma-seropositive patients with schizophrenia. METHOD: The rate of serum reactivity to Toxoplasma in 600 schizophrenia, 600 affective disorders, and 400 controls was investigated. The clinical symptoms of the schizophrenia patients were scored and compared. RESULTS: The rate of IgG antibody, not IgM in the schizophrenia patients, was higher than the control groups, and the odds ratio of schizophrenia associated with IgG antibody was 2.22-5.12. The affective disorders did not differ in the rate of IgG or IgM antibody from the normal or the physical disease control. The seropositive schizophrenia patients had higher scores on the positive subscale and three components of Positive and Negative Symptoms Scale than the seronegative patients. CONCLUSION: This study lent further weight to the hypothesis that exposure to Toxoplasma may be a risk factor for schizophrenia. SN - 0001-690X UR - https://www.unboundmedicine.com/medline/citation/16774660/Prevalence_of_Toxoplasma_infection_in_first_episode_schizophrenia_and_comparison_between_Toxoplasma_seropositive_and_Toxoplasma_seronegative_schizophrenia_ L2 - https://doi.org/10.1111/j.1600-0447.2006.00780.x DB - PRIME DP - Unbound Medicine ER -