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Height, weight and body mass index in early adulthood and risk of schizophrenia.
Acta Psychiatr Scand 2006; 114(1):49-54AP

Abstract

OBJECTIVE

To illuminate the possible associations between height, weight, and body mass index (BMI) during early adulthood and the development of schizophrenia.

METHOD

This prospective study is based on an all-male sample of 3210 individuals from the Copenhagen Perinatal Cohort, comprising individuals born between 1959 and 1961. In 1999, cases of schizophrenia were identified in the Danish Psychiatric Central Register, and the cases were compared with the cohort pool of controls with respect to height, weight, and BMI from draft records. The effect of low BMI was adjusted for parental social status when the cohort members were 1 year old, birth weight, birth length, and maternal pre-pregnancy BMI.

RESULTS

Forty-five cases of schizophrenia had a lower young adult mean body weight and BMI than controls. A significant inverse relationship between BMI and risk of later schizophrenia was found. For each unit increase in BMI, the adjusted odds ratio was 0.81 (95% CI, 0.70-0.93) and the risk of schizophrenia decreased by 19%. Excluding individuals who had been admitted to an in-patient facility before or within 5 years after appearing before the draft board, yielded virtually the same results. No significant differences between cases and controls were observed with respect to adult height.

CONCLUSION

Independent of several possible confounders, an inverse relationship between young adult BMI and risk of later development of schizophrenia was demonstrated in this all-male sample.

Authors+Show Affiliations

Department of Psychiatry, Copenhagen University Hospital, Amager, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16774661

Citation

Sørensen, H J., et al. "Height, Weight and Body Mass Index in Early Adulthood and Risk of Schizophrenia." Acta Psychiatrica Scandinavica, vol. 114, no. 1, 2006, pp. 49-54.
Sørensen HJ, Mortensen EL, Reinisch JM, et al. Height, weight and body mass index in early adulthood and risk of schizophrenia. Acta Psychiatr Scand. 2006;114(1):49-54.
Sørensen, H. J., Mortensen, E. L., Reinisch, J. M., & Mednick, S. A. (2006). Height, weight and body mass index in early adulthood and risk of schizophrenia. Acta Psychiatrica Scandinavica, 114(1), pp. 49-54.
Sørensen HJ, et al. Height, Weight and Body Mass Index in Early Adulthood and Risk of Schizophrenia. Acta Psychiatr Scand. 2006;114(1):49-54. PubMed PMID: 16774661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Height, weight and body mass index in early adulthood and risk of schizophrenia. AU - Sørensen,H J, AU - Mortensen,E L, AU - Reinisch,J M, AU - Mednick,S A, PY - 2006/6/16/pubmed PY - 2007/7/3/medline PY - 2006/6/16/entrez SP - 49 EP - 54 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 114 IS - 1 N2 - OBJECTIVE: To illuminate the possible associations between height, weight, and body mass index (BMI) during early adulthood and the development of schizophrenia. METHOD: This prospective study is based on an all-male sample of 3210 individuals from the Copenhagen Perinatal Cohort, comprising individuals born between 1959 and 1961. In 1999, cases of schizophrenia were identified in the Danish Psychiatric Central Register, and the cases were compared with the cohort pool of controls with respect to height, weight, and BMI from draft records. The effect of low BMI was adjusted for parental social status when the cohort members were 1 year old, birth weight, birth length, and maternal pre-pregnancy BMI. RESULTS: Forty-five cases of schizophrenia had a lower young adult mean body weight and BMI than controls. A significant inverse relationship between BMI and risk of later schizophrenia was found. For each unit increase in BMI, the adjusted odds ratio was 0.81 (95% CI, 0.70-0.93) and the risk of schizophrenia decreased by 19%. Excluding individuals who had been admitted to an in-patient facility before or within 5 years after appearing before the draft board, yielded virtually the same results. No significant differences between cases and controls were observed with respect to adult height. CONCLUSION: Independent of several possible confounders, an inverse relationship between young adult BMI and risk of later development of schizophrenia was demonstrated in this all-male sample. SN - 0001-690X UR - https://www.unboundmedicine.com/medline/citation/16774661/Height_weight_and_body_mass_index_in_early_adulthood_and_risk_of_schizophrenia_ L2 - https://doi.org/10.1111/j.1600-0447.2006.00784.x DB - PRIME DP - Unbound Medicine ER -