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Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids.
Am J Clin Nutr. 1991 Aug; 54(2):351-8.AJ

Abstract

Platelet function and fatty acid composition were investigated in 30 healthy male subjects who ate a controlled-saturated-fatty-acid (baseline) diet for 3 wk and then consumed either safflower oil or canola oil as a major fat source for 8 wk. Fatty acid composition of platelet phospholipids reflected changes in dietary fatty acid composition. Compared with baseline a 35% decrease (P less than 0.05) in arachidonic acid was observed in platelet phospholipids of the canola-oil diet group while long chain n-3 fatty acids rose 7-26% (P greater than 0.05). Compared with baseline both unsaturated-fatty-acid diets reduced platelet aggregation at 3 wk of oil-based diet feeding (P less than 0.01) whereas only canola oil influenced platelet function (lowered ATP secretion) at 8 wk (P less than 0.01). No significant difference was observed in thromboxane B2 concentrations between oil-treatment groups at 8 wk. Both oil-based diets had short-term beneficial effects on platelet function but the effect of canola oil persisted longer.

Authors+Show Affiliations

Department of Human Nutrition, Ohio State University, Columbus.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1677525

Citation

Kwon, J S., et al. "Effects of Diets High in Saturated Fatty Acids, Canola Oil, or Safflower Oil On Platelet Function, Thromboxane B2 Formation, and Fatty Acid Composition of Platelet Phospholipids." The American Journal of Clinical Nutrition, vol. 54, no. 2, 1991, pp. 351-8.
Kwon JS, Snook JT, Wardlaw GM, et al. Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. Am J Clin Nutr. 1991;54(2):351-8.
Kwon, J. S., Snook, J. T., Wardlaw, G. M., & Hwang, D. H. (1991). Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. The American Journal of Clinical Nutrition, 54(2), 351-8.
Kwon JS, et al. Effects of Diets High in Saturated Fatty Acids, Canola Oil, or Safflower Oil On Platelet Function, Thromboxane B2 Formation, and Fatty Acid Composition of Platelet Phospholipids. Am J Clin Nutr. 1991;54(2):351-8. PubMed PMID: 1677525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. AU - Kwon,J S, AU - Snook,J T, AU - Wardlaw,G M, AU - Hwang,D H, PY - 1991/8/1/pubmed PY - 1991/8/1/medline PY - 1991/8/1/entrez SP - 351 EP - 8 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 54 IS - 2 N2 - Platelet function and fatty acid composition were investigated in 30 healthy male subjects who ate a controlled-saturated-fatty-acid (baseline) diet for 3 wk and then consumed either safflower oil or canola oil as a major fat source for 8 wk. Fatty acid composition of platelet phospholipids reflected changes in dietary fatty acid composition. Compared with baseline a 35% decrease (P less than 0.05) in arachidonic acid was observed in platelet phospholipids of the canola-oil diet group while long chain n-3 fatty acids rose 7-26% (P greater than 0.05). Compared with baseline both unsaturated-fatty-acid diets reduced platelet aggregation at 3 wk of oil-based diet feeding (P less than 0.01) whereas only canola oil influenced platelet function (lowered ATP secretion) at 8 wk (P less than 0.01). No significant difference was observed in thromboxane B2 concentrations between oil-treatment groups at 8 wk. Both oil-based diets had short-term beneficial effects on platelet function but the effect of canola oil persisted longer. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/1677525/Effects_of_diets_high_in_saturated_fatty_acids_canola_oil_or_safflower_oil_on_platelet_function_thromboxane_B2_formation_and_fatty_acid_composition_of_platelet_phospholipids_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/54.2.351 DB - PRIME DP - Unbound Medicine ER -