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ACE ID genotype and the muscle strength and size response to unilateral resistance training.
Med Sci Sports Exerc. 2006 Jun; 38(6):1074-81.MS

Abstract

PURPOSE

To examine associations among the angiotensin I-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism and the response to a 12-wk (2 d.wk) unilateral, upper-arm resistance training (RT) program in the trained (T, nondominant) and untrained (UT, dominant) arms.

METHODS

Subjects were 631 (mean+/-SEM, 24.2+/-0.2 yr) white (80%) men (42%) and women (58%). The ACE ID genotype was in Hardy-Weinberg equilibrium with frequencies of 23.1, 46.1, and 30.8% for ACE II, ID, and DD, respectively (chi=1.688, P=0.430). Maximum voluntary contraction (MVC) and one-repetition maximum (1RM) assessed peak elbow flexor muscle strength. Magnetic resonance imaging measured biceps muscle cross-sectional area (CSA). Multiple variable and repeated-measures ANCOVA tested whether muscle strength and size differed at baseline and pre- to post-RT among T and UT and ACE ID genotype.

RESULTS

Baseline muscle strength and size were greater in UT than T (P<0.001) and did not differ among ACE ID genotype in either arm (P >or= 0.05). In T, MVC increases were greater for ACE II/ID (22%) than DD (17%) (P<0.05), whereas 1RM (51%) and CSA (19%) gains were not different among ACE ID genotype pre- to post-RT (P >or= 0.05). In UT, MVC increased among ACE II/ID (7%) (P<0.001) but was similar among ACE DD (2%) pre- to post-RT (P >or= 0.05). In UT, 1RM (11%) and CSA (2%) increases were greater for ACE DD/ID than ACE II (1RM, 7%; CSA, -0.1%) (P<0.05). ACE ID genotype explained approximately 1% of the MVC response to RT in T and approximately 2% of MVC, 2% of 1RM, and 4% of CSA response in UT (P<0.05).

CONCLUSION

ACE ID genotype is associated with the contralateral effects of unilateral RT, perhaps more so than with the muscle strength and size adaptations that result from RT.

Authors+Show Affiliations

School of Allied Health, University of Connecticut, Storrs, CT 06269-2101, USA. Linda.Pescatello@uconn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16775548

Citation

Pescatello, Linda S., et al. "ACE ID Genotype and the Muscle Strength and Size Response to Unilateral Resistance Training." Medicine and Science in Sports and Exercise, vol. 38, no. 6, 2006, pp. 1074-81.
Pescatello LS, Kostek MA, Gordish-Dressman H, et al. ACE ID genotype and the muscle strength and size response to unilateral resistance training. Med Sci Sports Exerc. 2006;38(6):1074-81.
Pescatello, L. S., Kostek, M. A., Gordish-Dressman, H., Thompson, P. D., Seip, R. L., Price, T. B., Angelopoulos, T. J., Clarkson, P. M., Gordon, P. M., Moyna, N. M., Visich, P. S., Zoeller, R. F., Devaney, J. M., & Hoffman, E. P. (2006). ACE ID genotype and the muscle strength and size response to unilateral resistance training. Medicine and Science in Sports and Exercise, 38(6), 1074-81.
Pescatello LS, et al. ACE ID Genotype and the Muscle Strength and Size Response to Unilateral Resistance Training. Med Sci Sports Exerc. 2006;38(6):1074-81. PubMed PMID: 16775548.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ACE ID genotype and the muscle strength and size response to unilateral resistance training. AU - Pescatello,Linda S, AU - Kostek,Matthew A, AU - Gordish-Dressman,Heather, AU - Thompson,Paul D, AU - Seip,Richard L, AU - Price,Thomas B, AU - Angelopoulos,Theodore J, AU - Clarkson,Priscilla M, AU - Gordon,Paul M, AU - Moyna,Niall M, AU - Visich,Paul S, AU - Zoeller,Robert F, AU - Devaney,Joseph M, AU - Hoffman,Eric P, PY - 2006/6/16/pubmed PY - 2006/10/28/medline PY - 2006/6/16/entrez SP - 1074 EP - 81 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 38 IS - 6 N2 - PURPOSE: To examine associations among the angiotensin I-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism and the response to a 12-wk (2 d.wk) unilateral, upper-arm resistance training (RT) program in the trained (T, nondominant) and untrained (UT, dominant) arms. METHODS: Subjects were 631 (mean+/-SEM, 24.2+/-0.2 yr) white (80%) men (42%) and women (58%). The ACE ID genotype was in Hardy-Weinberg equilibrium with frequencies of 23.1, 46.1, and 30.8% for ACE II, ID, and DD, respectively (chi=1.688, P=0.430). Maximum voluntary contraction (MVC) and one-repetition maximum (1RM) assessed peak elbow flexor muscle strength. Magnetic resonance imaging measured biceps muscle cross-sectional area (CSA). Multiple variable and repeated-measures ANCOVA tested whether muscle strength and size differed at baseline and pre- to post-RT among T and UT and ACE ID genotype. RESULTS: Baseline muscle strength and size were greater in UT than T (P<0.001) and did not differ among ACE ID genotype in either arm (P >or= 0.05). In T, MVC increases were greater for ACE II/ID (22%) than DD (17%) (P<0.05), whereas 1RM (51%) and CSA (19%) gains were not different among ACE ID genotype pre- to post-RT (P >or= 0.05). In UT, MVC increased among ACE II/ID (7%) (P<0.001) but was similar among ACE DD (2%) pre- to post-RT (P >or= 0.05). In UT, 1RM (11%) and CSA (2%) increases were greater for ACE DD/ID than ACE II (1RM, 7%; CSA, -0.1%) (P<0.05). ACE ID genotype explained approximately 1% of the MVC response to RT in T and approximately 2% of MVC, 2% of 1RM, and 4% of CSA response in UT (P<0.05). CONCLUSION: ACE ID genotype is associated with the contralateral effects of unilateral RT, perhaps more so than with the muscle strength and size adaptations that result from RT. SN - 0195-9131 UR - https://www.unboundmedicine.com/medline/citation/16775548/ACE_ID_genotype_and_the_muscle_strength_and_size_response_to_unilateral_resistance_training_ L2 - https://doi.org/10.1249/01.mss.0000222835.28273.80 DB - PRIME DP - Unbound Medicine ER -