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Oxidative stress response to aerobic exercise: comparison of antioxidant supplements.
Med Sci Sports Exerc. 2006 Jun; 38(6):1098-105.MS

Abstract

PURPOSE

To compare the effects of two antioxidant formulas on biomarkers of oxidative stress before and after aerobic exercise.

METHODS

Aerobically trained men (N=25) and women (N=23) were assigned to one of three treatments: 400 IU of vitamin E+1 g of vitamin C (V; N=15), a fruit and vegetable juice powder concentrate (FV; N=16), or a placebo (P; N=17). Subjects ran for 30 min at 80% VO(2 max) before, after 2 wk of supplementation, and after a 1-wk washout period. Blood samples were taken before and immediately after exercise and analyzed for protein carbonyls (PC), malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), and vitamins C and E.

RESULTS

The V treatment increased plasma vitamin C and E after 2 wk (P <or= 0.05), with no change in the FV or P. Postexercise PC values were elevated for all treatments after all exercise bouts (P< 0.0001). Both V and FV attenuated the exercise-induced increase in PC after 2 wk of supplementation (V=21%, FV=17%), and after the 1-wk washout (V=13%, FV=6%) compared with P (P<0.05), with no differences between V and FV. MDA was unaffected by exercise and treatment. A treatment main effect for 8-OHdG was noted, with values for V lower than for FV and P (4.5+/-2.5, 5.5+/-2.7, and 6.0+/-2.5 ng.mL, respectively; P=0.0002). No exercise session or time main effect was noted for 8-OHdG, suggesting that the lower mean value for the V treatment group was not a result of the supplementation.

CONCLUSION

These data suggest that V and FV supplementation for 2 wk can attenuate the rise in PC after 30 min of aerobic exercise, even after a 1-wk washout, without an impact on plasma MDA or 8-OHdG.

Authors+Show Affiliations

Department of Health and Sport Sciences, University of Memphis, Memphis, TN 38512, USA. rbloomer@memphis.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16775552

Citation

Bloomer, Richard J., et al. "Oxidative Stress Response to Aerobic Exercise: Comparison of Antioxidant Supplements." Medicine and Science in Sports and Exercise, vol. 38, no. 6, 2006, pp. 1098-105.
Bloomer RJ, Goldfarb AH, McKenzie MJ. Oxidative stress response to aerobic exercise: comparison of antioxidant supplements. Med Sci Sports Exerc. 2006;38(6):1098-105.
Bloomer, R. J., Goldfarb, A. H., & McKenzie, M. J. (2006). Oxidative stress response to aerobic exercise: comparison of antioxidant supplements. Medicine and Science in Sports and Exercise, 38(6), 1098-105.
Bloomer RJ, Goldfarb AH, McKenzie MJ. Oxidative Stress Response to Aerobic Exercise: Comparison of Antioxidant Supplements. Med Sci Sports Exerc. 2006;38(6):1098-105. PubMed PMID: 16775552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress response to aerobic exercise: comparison of antioxidant supplements. AU - Bloomer,Richard J, AU - Goldfarb,Allan H, AU - McKenzie,Michael J, PY - 2006/6/16/pubmed PY - 2006/10/28/medline PY - 2006/6/16/entrez SP - 1098 EP - 105 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 38 IS - 6 N2 - PURPOSE: To compare the effects of two antioxidant formulas on biomarkers of oxidative stress before and after aerobic exercise. METHODS: Aerobically trained men (N=25) and women (N=23) were assigned to one of three treatments: 400 IU of vitamin E+1 g of vitamin C (V; N=15), a fruit and vegetable juice powder concentrate (FV; N=16), or a placebo (P; N=17). Subjects ran for 30 min at 80% VO(2 max) before, after 2 wk of supplementation, and after a 1-wk washout period. Blood samples were taken before and immediately after exercise and analyzed for protein carbonyls (PC), malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), and vitamins C and E. RESULTS: The V treatment increased plasma vitamin C and E after 2 wk (P <or= 0.05), with no change in the FV or P. Postexercise PC values were elevated for all treatments after all exercise bouts (P< 0.0001). Both V and FV attenuated the exercise-induced increase in PC after 2 wk of supplementation (V=21%, FV=17%), and after the 1-wk washout (V=13%, FV=6%) compared with P (P<0.05), with no differences between V and FV. MDA was unaffected by exercise and treatment. A treatment main effect for 8-OHdG was noted, with values for V lower than for FV and P (4.5+/-2.5, 5.5+/-2.7, and 6.0+/-2.5 ng.mL, respectively; P=0.0002). No exercise session or time main effect was noted for 8-OHdG, suggesting that the lower mean value for the V treatment group was not a result of the supplementation. CONCLUSION: These data suggest that V and FV supplementation for 2 wk can attenuate the rise in PC after 30 min of aerobic exercise, even after a 1-wk washout, without an impact on plasma MDA or 8-OHdG. SN - 0195-9131 UR - https://www.unboundmedicine.com/medline/citation/16775552/Oxidative_stress_response_to_aerobic_exercise:_comparison_of_antioxidant_supplements_ L2 - https://doi.org/10.1249/01.mss.0000222839.51144.3e DB - PRIME DP - Unbound Medicine ER -