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Effects of dietary protein on glucose homeostasis.

Abstract

PURPOSE OF REVIEW

Despite the proven efficacy of the established high-carbohydrate diets for treatment and prevention of obesity and type 2 diabetes, alternative diets including high-protein, high-fat, low-carbohydrate diets have become increasingly popular. The purpose of this review is to discuss potential effects of increased protein intake on glucose metabolism and body weight.

RECENT FINDINGS

Recent intervention trials revealed that, in the short-term, the intake of proteins at the expense of carbohydrates increases satiety and thereby lowers intake of calories. High protein intake augments prandial insulin secretion and might thereby improve glycaemic control in type 2 diabetic patients. On the other hand, epidemiological studies suggest that chronic high dietary protein intake is associated with increased incidence of type 2 diabetes. Furthermore, a short-term increase in plasma amino acid concentrations has been shown to directly induce insulin resistance in skeletal muscle and stimulate endogenous glucose production.

SUMMARY

Dietary proteins and amino acids are potent modulators of glucose metabolism and might also affect satiety and energy intake. However, due to the lack of well-controlled long-term studies the optimal macronutrient composition for treatment and prevention of obesity and type 2 diabetes is not known.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16778578

Citation

Promintzer, Miriam, and Michael Krebs. "Effects of Dietary Protein On Glucose Homeostasis." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 9, no. 4, 2006, pp. 463-8.
Promintzer M, Krebs M. Effects of dietary protein on glucose homeostasis. Curr Opin Clin Nutr Metab Care. 2006;9(4):463-8.
Promintzer, M., & Krebs, M. (2006). Effects of dietary protein on glucose homeostasis. Current Opinion in Clinical Nutrition and Metabolic Care, 9(4), pp. 463-8.
Promintzer M, Krebs M. Effects of Dietary Protein On Glucose Homeostasis. Curr Opin Clin Nutr Metab Care. 2006;9(4):463-8. PubMed PMID: 16778578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary protein on glucose homeostasis. AU - Promintzer,Miriam, AU - Krebs,Michael, PY - 2006/6/17/pubmed PY - 2006/12/9/medline PY - 2006/6/17/entrez SP - 463 EP - 8 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 9 IS - 4 N2 - PURPOSE OF REVIEW: Despite the proven efficacy of the established high-carbohydrate diets for treatment and prevention of obesity and type 2 diabetes, alternative diets including high-protein, high-fat, low-carbohydrate diets have become increasingly popular. The purpose of this review is to discuss potential effects of increased protein intake on glucose metabolism and body weight. RECENT FINDINGS: Recent intervention trials revealed that, in the short-term, the intake of proteins at the expense of carbohydrates increases satiety and thereby lowers intake of calories. High protein intake augments prandial insulin secretion and might thereby improve glycaemic control in type 2 diabetic patients. On the other hand, epidemiological studies suggest that chronic high dietary protein intake is associated with increased incidence of type 2 diabetes. Furthermore, a short-term increase in plasma amino acid concentrations has been shown to directly induce insulin resistance in skeletal muscle and stimulate endogenous glucose production. SUMMARY: Dietary proteins and amino acids are potent modulators of glucose metabolism and might also affect satiety and energy intake. However, due to the lack of well-controlled long-term studies the optimal macronutrient composition for treatment and prevention of obesity and type 2 diabetes is not known. SN - 1363-1950 UR - https://www.unboundmedicine.com/medline/citation/16778578/Effects_of_dietary_protein_on_glucose_homeostasis_ L2 - http://Insights.ovid.com/pubmed?pmid=16778578 DB - PRIME DP - Unbound Medicine ER -