Tags

Type your tag names separated by a space and hit enter

Keratometry, optic disc dimensions, and degree and progression of glaucomatous optic nerve damage.
J Glaucoma. 2006 Jun; 15(3):206-12.JG

Abstract

PURPOSE

To evaluate whether keratometric readings as a measure of corneal shape are associated with optic disc dimensions and with the degree and rate of perimetric progression of chronic open-angle glaucoma or ocular hypertension.

METHODS

The hospital-based observational study included 1826 eyes of 936 patients with ocular hypertension, patients with chronic open-angle glaucoma, or normal individuals. For 733 ocular hypertensive or glaucomatous eyes, follow-up examinations were performed with a mean follow-up time of 58.0+/-34.7 months. Observation procedures were keratometry, morphometric optic disc analysis, tonometry, and perimetry.

RESULTS

In the normal study group, area of the neuroretinal rim, alpha zone and beta zone of parapapillary atrophy, and retinal vessel diameter were not significantly associated with keratometric readings. In the entire study population, the optic disc area was significantly (P<0.001; r=-0.27) correlated with low keratometric readings as expressed in diopters. Keratometric readings were significantly (P<0.001 adjusted for age, intraocular pressure, baseline damage, and corneal asphericity) smaller in the normal-pressure glaucoma group than in the normal study group and in the groups with ocular hypertension or primary and secondary open-angle glaucoma. Rate of perimetric progression was not significantly associated with low keratometric readings, either in simple or in multiple Cox regression analysis, controlling for baseline damage, ocular hypertension, age, corneal asphericity, and intraocular pressure.

CONCLUSIONS

Large optic disc area is statistically significantly, but clinically weakly, correlated with low keratometric readings (diopters). In Caucasian individuals with ocular hypertension and patients with chronic open-angle glaucoma, the rate of development or progression of glaucomatous visual field defects is not significantly associated with keratometric readings.

Authors+Show Affiliations

Department of Ophthalmology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany. JostJonas@augen.ma.uni-heidelberg.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16778642

Citation

Jonas, Jost B., et al. "Keratometry, Optic Disc Dimensions, and Degree and Progression of Glaucomatous Optic Nerve Damage." Journal of Glaucoma, vol. 15, no. 3, 2006, pp. 206-12.
Jonas JB, Stroux A, Martus P, et al. Keratometry, optic disc dimensions, and degree and progression of glaucomatous optic nerve damage. J Glaucoma. 2006;15(3):206-12.
Jonas, J. B., Stroux, A., Martus, P., & Budde, W. (2006). Keratometry, optic disc dimensions, and degree and progression of glaucomatous optic nerve damage. Journal of Glaucoma, 15(3), 206-12.
Jonas JB, et al. Keratometry, Optic Disc Dimensions, and Degree and Progression of Glaucomatous Optic Nerve Damage. J Glaucoma. 2006;15(3):206-12. PubMed PMID: 16778642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Keratometry, optic disc dimensions, and degree and progression of glaucomatous optic nerve damage. AU - Jonas,Jost B, AU - Stroux,Andrea, AU - Martus,Peter, AU - Budde,Wido, PY - 2006/6/17/pubmed PY - 2006/7/18/medline PY - 2006/6/17/entrez SP - 206 EP - 12 JF - Journal of glaucoma JO - J Glaucoma VL - 15 IS - 3 N2 - PURPOSE: To evaluate whether keratometric readings as a measure of corneal shape are associated with optic disc dimensions and with the degree and rate of perimetric progression of chronic open-angle glaucoma or ocular hypertension. METHODS: The hospital-based observational study included 1826 eyes of 936 patients with ocular hypertension, patients with chronic open-angle glaucoma, or normal individuals. For 733 ocular hypertensive or glaucomatous eyes, follow-up examinations were performed with a mean follow-up time of 58.0+/-34.7 months. Observation procedures were keratometry, morphometric optic disc analysis, tonometry, and perimetry. RESULTS: In the normal study group, area of the neuroretinal rim, alpha zone and beta zone of parapapillary atrophy, and retinal vessel diameter were not significantly associated with keratometric readings. In the entire study population, the optic disc area was significantly (P<0.001; r=-0.27) correlated with low keratometric readings as expressed in diopters. Keratometric readings were significantly (P<0.001 adjusted for age, intraocular pressure, baseline damage, and corneal asphericity) smaller in the normal-pressure glaucoma group than in the normal study group and in the groups with ocular hypertension or primary and secondary open-angle glaucoma. Rate of perimetric progression was not significantly associated with low keratometric readings, either in simple or in multiple Cox regression analysis, controlling for baseline damage, ocular hypertension, age, corneal asphericity, and intraocular pressure. CONCLUSIONS: Large optic disc area is statistically significantly, but clinically weakly, correlated with low keratometric readings (diopters). In Caucasian individuals with ocular hypertension and patients with chronic open-angle glaucoma, the rate of development or progression of glaucomatous visual field defects is not significantly associated with keratometric readings. SN - 1057-0829 UR - https://www.unboundmedicine.com/medline/citation/16778642/Keratometry_optic_disc_dimensions_and_degree_and_progression_of_glaucomatous_optic_nerve_damage_ L2 - https://doi.org/10.1097/01.ijg.0000212209.25642.01 DB - PRIME DP - Unbound Medicine ER -