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The immune response to parvovirus B19 exposure in previously seronegative and seropositive individuals.
J Infect Dis. 2006 Jul 15; 194(2):154-8.JI

Abstract

Little information is available on the immune response to parvovirus B19 after the administration of contaminated blood products. In the present study, we found that levels of B19 IgG in B19-seropositive recipients protect against reinfection and, after transfusion with pooled plasma containing B19 DNA (1.6 x 10(8) IU/mL), increase from 19-39 IU/mL to 50-100 IU/mL. We found that, in the presence of 1.6-2.2 x 10(8) IU of B19 DNA/mL in B19-seronegative recipients, a pooled-plasma B19 IgG level of 59.5 IU/mL is insufficient to prevent B19 transmission and subsequent seroconversion. These data should lead to improvements in the assessment of blood-product safety.

Authors+Show Affiliations

Department of Biology and National Institute for Cellular Biotechnology, National University of Ireland, Maynooth, County Kildare, Ireland. sean.doyle@nuim.ieNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16779720

Citation

Doyle, Sean, and Amanda Corcoran. "The Immune Response to Parvovirus B19 Exposure in Previously Seronegative and Seropositive Individuals." The Journal of Infectious Diseases, vol. 194, no. 2, 2006, pp. 154-8.
Doyle S, Corcoran A. The immune response to parvovirus B19 exposure in previously seronegative and seropositive individuals. J Infect Dis. 2006;194(2):154-8.
Doyle, S., & Corcoran, A. (2006). The immune response to parvovirus B19 exposure in previously seronegative and seropositive individuals. The Journal of Infectious Diseases, 194(2), 154-8.
Doyle S, Corcoran A. The Immune Response to Parvovirus B19 Exposure in Previously Seronegative and Seropositive Individuals. J Infect Dis. 2006 Jul 15;194(2):154-8. PubMed PMID: 16779720.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The immune response to parvovirus B19 exposure in previously seronegative and seropositive individuals. AU - Doyle,Sean, AU - Corcoran,Amanda, Y1 - 2006/06/09/ PY - 2006/01/13/received PY - 2006/03/07/accepted PY - 2006/6/17/pubmed PY - 2006/8/10/medline PY - 2006/6/17/entrez SP - 154 EP - 8 JF - The Journal of infectious diseases JO - J Infect Dis VL - 194 IS - 2 N2 - Little information is available on the immune response to parvovirus B19 after the administration of contaminated blood products. In the present study, we found that levels of B19 IgG in B19-seropositive recipients protect against reinfection and, after transfusion with pooled plasma containing B19 DNA (1.6 x 10(8) IU/mL), increase from 19-39 IU/mL to 50-100 IU/mL. We found that, in the presence of 1.6-2.2 x 10(8) IU of B19 DNA/mL in B19-seronegative recipients, a pooled-plasma B19 IgG level of 59.5 IU/mL is insufficient to prevent B19 transmission and subsequent seroconversion. These data should lead to improvements in the assessment of blood-product safety. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/16779720/The_immune_response_to_parvovirus_B19_exposure_in_previously_seronegative_and_seropositive_individuals_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/505226 DB - PRIME DP - Unbound Medicine ER -