Tags

Type your tag names separated by a space and hit enter

Lemon oil vapor causes an anti-stress effect via modulating the 5-HT and DA activities in mice.
Behav Brain Res. 2006 Sep 25; 172(2):240-9.BB

Abstract

We examined the anti-stress action of the essential oils of lavender, rose, and lemon using an elevated plus-maze task (EPM), a forced swimming task (FST), and an open field task (OFT) in mice. Lemon oil had the strongest anti-stress effect in all three behavioral tasks. We further investigated a regulatory mechanism of the lemon oil by pre-treatments with agonists or antagonists to benzodiazepine, 5-HT, DA, and adrenaline receptors by the EPM and the FST. The anti-stress effect of lemon oil was significantly blocked by pre-treatment with frumazenil, benzodiazepine receptor antagonist, or apomorphine, a nonselective DA receptor agonist. In contrast, agonists or antagonists to the 5-HT receptor and the alpha-2 adrenaline receptor did not affect the anti-stress effect of lemon oil. Buspirone, DOI, and mianserine blocked the antidepressant-like effect of lemon oil in the FST, but WAY100,635 did not. These findings suggest that the antidepressant-like effect of lemon oil is closely related with the 5-HTnergic pathway, especially via 5-HT(1A) receptor. Moreover, the lemon oil significantly accelerated the metabolic turnover of DA in the hippocampus and of 5-HT in the prefrontal cortex and striatum. These results suggest that lemon oil possesses anxiolytic, antidepressant-like effects via the suppression of DA activity related to enhanced 5-HTnergic neurons.

Authors+Show Affiliations

Graduate School of Veterinary Science, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753-8515, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16780969

Citation

Komiya, Migiwa, et al. "Lemon Oil Vapor Causes an Anti-stress Effect Via Modulating the 5-HT and DA Activities in Mice." Behavioural Brain Research, vol. 172, no. 2, 2006, pp. 240-9.
Komiya M, Takeuchi T, Harada E. Lemon oil vapor causes an anti-stress effect via modulating the 5-HT and DA activities in mice. Behav Brain Res. 2006;172(2):240-9.
Komiya, M., Takeuchi, T., & Harada, E. (2006). Lemon oil vapor causes an anti-stress effect via modulating the 5-HT and DA activities in mice. Behavioural Brain Research, 172(2), 240-9.
Komiya M, Takeuchi T, Harada E. Lemon Oil Vapor Causes an Anti-stress Effect Via Modulating the 5-HT and DA Activities in Mice. Behav Brain Res. 2006 Sep 25;172(2):240-9. PubMed PMID: 16780969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lemon oil vapor causes an anti-stress effect via modulating the 5-HT and DA activities in mice. AU - Komiya,Migiwa, AU - Takeuchi,Takashi, AU - Harada,Etsumori, Y1 - 2006/06/15/ PY - 2006/02/04/received PY - 2006/05/03/revised PY - 2006/05/05/accepted PY - 2006/6/20/pubmed PY - 2006/12/29/medline PY - 2006/6/20/entrez SP - 240 EP - 9 JF - Behavioural brain research JO - Behav Brain Res VL - 172 IS - 2 N2 - We examined the anti-stress action of the essential oils of lavender, rose, and lemon using an elevated plus-maze task (EPM), a forced swimming task (FST), and an open field task (OFT) in mice. Lemon oil had the strongest anti-stress effect in all three behavioral tasks. We further investigated a regulatory mechanism of the lemon oil by pre-treatments with agonists or antagonists to benzodiazepine, 5-HT, DA, and adrenaline receptors by the EPM and the FST. The anti-stress effect of lemon oil was significantly blocked by pre-treatment with frumazenil, benzodiazepine receptor antagonist, or apomorphine, a nonselective DA receptor agonist. In contrast, agonists or antagonists to the 5-HT receptor and the alpha-2 adrenaline receptor did not affect the anti-stress effect of lemon oil. Buspirone, DOI, and mianserine blocked the antidepressant-like effect of lemon oil in the FST, but WAY100,635 did not. These findings suggest that the antidepressant-like effect of lemon oil is closely related with the 5-HTnergic pathway, especially via 5-HT(1A) receptor. Moreover, the lemon oil significantly accelerated the metabolic turnover of DA in the hippocampus and of 5-HT in the prefrontal cortex and striatum. These results suggest that lemon oil possesses anxiolytic, antidepressant-like effects via the suppression of DA activity related to enhanced 5-HTnergic neurons. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/16780969/Lemon_oil_vapor_causes_an_anti_stress_effect_via_modulating_the_5_HT_and_DA_activities_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(06)00279-8 DB - PRIME DP - Unbound Medicine ER -