Tags

Type your tag names separated by a space and hit enter

Changes in hair weight in men with androgenetic alopecia after treatment with finasteride (1 mg daily): three- and 4-year results.
J Am Acad Dermatol. 2006 Jul; 55(1):71-4.JA

Abstract

BACKGROUND

We previously reported the effects of finasteride on scalp hair weight and count over a 2-year period in men with androgenetic alopecia (AGA).

OBJECTIVE

Our purpose was to evaluate the effects of finasteride on hair weight and count over 4 years in men with AGA.

METHODS

Men with AGA were randomized to receive finasteride (1 mg/d) or placebo for 192 weeks. Results of the second (weeks 96-144) and third (weeks 144-192) extension periods are reported.

RESULTS

Finasteride increased hair weight at 144 and 192 weeks (week 192: finasteride, 21.6% increase from baseline; placebo, 24.5% decrease from baseline; net increase in hair weight for finasteride vs placebo = 46.0%, P < .001). Hair count also increased with finasteride at 144 and 192 weeks (week 192: finasteride, 7.2% increase from baseline; placebo, 13.0% decrease from baseline; net increase in hair count for finasteride vs placebo = 20.3%, P < .05). Finasteride was generally well tolerated.

LIMITATIONS

Because this study was extended from its original 48-week duration to nearly 4 years, the sample size available for analysis decreased with time.

CONCLUSION

Long-term finasteride treatment led to sustained improvement in hair weight compared with placebo. Hair weight increased to a larger extent than hair count, implying that factors other than the number of hairs, such as increased growth rate (length) and thickness of hairs, contribute to the beneficial effects of finasteride in treated men.

Authors+Show Affiliations

Price VH
Department of Dermatology, University of California, San Francisco 94117, USA. pricev@derm.ucsf.edu
Menefee E
No affiliation info available
Sanchez M
No affiliation info available
Kaufman KD
No affiliation info available

MeSH

AdultAlopeciaDouble-Blind MethodDrug Administration ScheduleEnzyme InhibitorsFinasterideFollow-Up StudiesHairHumansMaleOrgan SizeTime Factors

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16781295

Citation

Price, Vera H., et al. "Changes in Hair Weight in Men With Androgenetic Alopecia After Treatment With Finasteride (1 Mg Daily): Three- and 4-year Results." Journal of the American Academy of Dermatology, vol. 55, no. 1, 2006, pp. 71-4.
Price VH, Menefee E, Sanchez M, et al. Changes in hair weight in men with androgenetic alopecia after treatment with finasteride (1 mg daily): three- and 4-year results. J Am Acad Dermatol. 2006;55(1):71-4.
Price, V. H., Menefee, E., Sanchez, M., & Kaufman, K. D. (2006). Changes in hair weight in men with androgenetic alopecia after treatment with finasteride (1 mg daily): three- and 4-year results. Journal of the American Academy of Dermatology, 55(1), 71-4.
Price VH, et al. Changes in Hair Weight in Men With Androgenetic Alopecia After Treatment With Finasteride (1 Mg Daily): Three- and 4-year Results. J Am Acad Dermatol. 2006;55(1):71-4. PubMed PMID: 16781295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in hair weight in men with androgenetic alopecia after treatment with finasteride (1 mg daily): three- and 4-year results. AU - Price,Vera H, AU - Menefee,Emory, AU - Sanchez,Matilde, AU - Kaufman,Keith D, Y1 - 2006/05/03/ PY - 2005/03/17/received PY - 2005/05/12/revised PY - 2005/07/04/accepted PY - 2006/6/20/pubmed PY - 2006/7/28/medline PY - 2006/6/20/entrez SP - 71 EP - 4 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 55 IS - 1 N2 - BACKGROUND: We previously reported the effects of finasteride on scalp hair weight and count over a 2-year period in men with androgenetic alopecia (AGA). OBJECTIVE: Our purpose was to evaluate the effects of finasteride on hair weight and count over 4 years in men with AGA. METHODS: Men with AGA were randomized to receive finasteride (1 mg/d) or placebo for 192 weeks. Results of the second (weeks 96-144) and third (weeks 144-192) extension periods are reported. RESULTS: Finasteride increased hair weight at 144 and 192 weeks (week 192: finasteride, 21.6% increase from baseline; placebo, 24.5% decrease from baseline; net increase in hair weight for finasteride vs placebo = 46.0%, P < .001). Hair count also increased with finasteride at 144 and 192 weeks (week 192: finasteride, 7.2% increase from baseline; placebo, 13.0% decrease from baseline; net increase in hair count for finasteride vs placebo = 20.3%, P < .05). Finasteride was generally well tolerated. LIMITATIONS: Because this study was extended from its original 48-week duration to nearly 4 years, the sample size available for analysis decreased with time. CONCLUSION: Long-term finasteride treatment led to sustained improvement in hair weight compared with placebo. Hair weight increased to a larger extent than hair count, implying that factors other than the number of hairs, such as increased growth rate (length) and thickness of hairs, contribute to the beneficial effects of finasteride in treated men. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/16781295/Changes_in_hair_weight_in_men_with_androgenetic_alopecia_after_treatment_with_finasteride__1_mg_daily_:_three__and_4_year_results_ DB - PRIME DP - Unbound Medicine ER -