Tags

Type your tag names separated by a space and hit enter

Oxidized low-density lipoprotein autoantibodies, chronic infections, and carotid atherosclerosis in a population-based study.
J Am Coll Cardiol. 2006 Jun 20; 47(12):2436-43.JACC

Abstract

OBJECTIVES

We investigated whether associations exist between immune reactions to oxidized low-density lipoproteins (OxLDLs), chronic infections, and carotid atherosclerosis as quantified by ultrasound.

BACKGROUND

Atherosclerosis is a chronic immuno-inflammatory disease wherein both oxidized lipids and infectious agents are incriminated as possible contributors.

METHODS

We measured immunoglobulin (Ig)G and IgM autoantibody titers to copper-oxidized-LDL and malondialdehyde-LDL (OxLDL-AB), IgG and IgM apolipoprotein B-100-immune complexes (ApoB-IC), and titers of antibodies to Escherichia coli and chlamydial lipopolysaccharide (LPS), mycobacterial heat shock protein 65 (mHSP65), Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus and evaluated their relationship to cardiovascular risk factors, chronic infections, and incident/progressive carotid atherosclerosis in the Bruneck study.

RESULTS

The OxLDL-AB and ApoB-IC levels remained stable over time as indicated by strong correlations between 1995 and 2000 measurements (p < 0.001 each). Significant associations existed between all OxLDL markers and antibody titers to pathogens, especially to E. coli-LPS and mHSP65. Both OxLDL-AB and ApoB-IC levels showed a rise with increasing pathogen burden. Notably, OxLDL-ABs were also elevated in subjects with chronic infection as defined by clinical criteria. Titers of IgG, but not IgM, OxLDL-AB, or ApoB-IC inversely correlated with total cholesterol, LDL cholesterol, and apoB concentrations. The IgG OxLDL markers were positively and IgM markers were inversely associated with incident and progressive carotid atherosclerosis in univariate analyses but were not independent predictors in multivariate analyses.

CONCLUSIONS

Our study provides evidence for an association between human oxLDL markers and chronic infections. Moreover, in this population-based study, neither IgG nor IgM OxLDL autoantibodies were independently predictive of atherosclerosis progression in the carotid arteries.

Authors+Show Affiliations

Department of Cardiac and Vascular Sciences, St. George's, University of London, London, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16781371

Citation

Mayr, Manuel, et al. "Oxidized Low-density Lipoprotein Autoantibodies, Chronic Infections, and Carotid Atherosclerosis in a Population-based Study." Journal of the American College of Cardiology, vol. 47, no. 12, 2006, pp. 2436-43.
Mayr M, Kiechl S, Tsimikas S, et al. Oxidized low-density lipoprotein autoantibodies, chronic infections, and carotid atherosclerosis in a population-based study. J Am Coll Cardiol. 2006;47(12):2436-43.
Mayr, M., Kiechl, S., Tsimikas, S., Miller, E., Sheldon, J., Willeit, J., Witztum, J. L., & Xu, Q. (2006). Oxidized low-density lipoprotein autoantibodies, chronic infections, and carotid atherosclerosis in a population-based study. Journal of the American College of Cardiology, 47(12), 2436-43.
Mayr M, et al. Oxidized Low-density Lipoprotein Autoantibodies, Chronic Infections, and Carotid Atherosclerosis in a Population-based Study. J Am Coll Cardiol. 2006 Jun 20;47(12):2436-43. PubMed PMID: 16781371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidized low-density lipoprotein autoantibodies, chronic infections, and carotid atherosclerosis in a population-based study. AU - Mayr,Manuel, AU - Kiechl,Stefan, AU - Tsimikas,Sotirios, AU - Miller,Elizabeth, AU - Sheldon,Joanna, AU - Willeit,Johann, AU - Witztum,Joseph L, AU - Xu,Qingbo, Y1 - 2006/05/30/ PY - 2005/09/21/received PY - 2006/01/03/revised PY - 2006/02/01/accepted PY - 2006/6/20/pubmed PY - 2006/7/26/medline PY - 2006/6/20/entrez SP - 2436 EP - 43 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 47 IS - 12 N2 - OBJECTIVES: We investigated whether associations exist between immune reactions to oxidized low-density lipoproteins (OxLDLs), chronic infections, and carotid atherosclerosis as quantified by ultrasound. BACKGROUND: Atherosclerosis is a chronic immuno-inflammatory disease wherein both oxidized lipids and infectious agents are incriminated as possible contributors. METHODS: We measured immunoglobulin (Ig)G and IgM autoantibody titers to copper-oxidized-LDL and malondialdehyde-LDL (OxLDL-AB), IgG and IgM apolipoprotein B-100-immune complexes (ApoB-IC), and titers of antibodies to Escherichia coli and chlamydial lipopolysaccharide (LPS), mycobacterial heat shock protein 65 (mHSP65), Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus and evaluated their relationship to cardiovascular risk factors, chronic infections, and incident/progressive carotid atherosclerosis in the Bruneck study. RESULTS: The OxLDL-AB and ApoB-IC levels remained stable over time as indicated by strong correlations between 1995 and 2000 measurements (p < 0.001 each). Significant associations existed between all OxLDL markers and antibody titers to pathogens, especially to E. coli-LPS and mHSP65. Both OxLDL-AB and ApoB-IC levels showed a rise with increasing pathogen burden. Notably, OxLDL-ABs were also elevated in subjects with chronic infection as defined by clinical criteria. Titers of IgG, but not IgM, OxLDL-AB, or ApoB-IC inversely correlated with total cholesterol, LDL cholesterol, and apoB concentrations. The IgG OxLDL markers were positively and IgM markers were inversely associated with incident and progressive carotid atherosclerosis in univariate analyses but were not independent predictors in multivariate analyses. CONCLUSIONS: Our study provides evidence for an association between human oxLDL markers and chronic infections. Moreover, in this population-based study, neither IgG nor IgM OxLDL autoantibodies were independently predictive of atherosclerosis progression in the carotid arteries. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/16781371/Oxidized_low_density_lipoprotein_autoantibodies_chronic_infections_and_carotid_atherosclerosis_in_a_population_based_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(06)00851-5 DB - PRIME DP - Unbound Medicine ER -