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The effect of Ginkgo biloba on functional measures in multiple sclerosis: a pilot randomized controlled trial.
Explore (NY) 2006; 2(1):19-24E

Abstract

BACKGROUND

Multiple sclerosis (MS) is a chronic demyelinating neurological disease afflicting young and middle-aged adults, resulting in problems with coordination, strength, cognition, affect, and sensation.

OBJECTIVE

The objective of this study was to determine whether a ginkgo extract (EGb 761) improved functional performance in individuals with MS.

DESIGN

This study used a double-blind, placebo-controlled, parallel group design. The end point was change between baseline (ie, preintervention) and follow-up evaluation following a regimen of four tablets per day at 60 mg per tablet for four weeks.

SETTING

The study was conducted in academic and clinical-based settings.

PATIENTS/PARTICIPANTS

Twenty-two individuals with MS were randomly assigned to either the treatment or control condition. Groups did not differ with respect to age, IQ, and education.

INTERVENTION

Half of the subjects received 240 mg per day of ginkgo special extract (EGb 761), and the other half received placebo.

MAIN OUTCOME MEASURE

The main outcome measures assessed depression (Center for Epidemiologic Studies of Depression Scale [CES-D]), anxiety (State-Trait Anxiety Inventory [STAI]), fatigue (Modified Fatigue Impact Scale [MFIS]); symptom severity (Symptom Inventory [SI]) and functional performance (Functional Assessment of Multiple Sclerosis [FAMS]).

RESULTS

The ginkgo group had significantly more individuals showing improvement on four or more measures with improvements associated with significantly larger effect sizes on measures of fatigue, symptom severity, and functionality. The ginkgo group also exhibited less fatigue at follow-up compared with the placebo group.

CONCLUSIONS

This exploratory pilot study showed that no adverse events or side effects were reported and that ginkgo exerted modest beneficial effects on select functional measures (eg, fatigue) among some individuals with MS.

Authors+Show Affiliations

University of North Carolina-Charlotte, Charlotte, NC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16781604

Citation

Johnson, Susan K., et al. "The Effect of Ginkgo Biloba On Functional Measures in Multiple Sclerosis: a Pilot Randomized Controlled Trial." Explore (New York, N.Y.), vol. 2, no. 1, 2006, pp. 19-24.
Johnson SK, Diamond BJ, Rausch S, et al. The effect of Ginkgo biloba on functional measures in multiple sclerosis: a pilot randomized controlled trial. Explore (NY). 2006;2(1):19-24.
Johnson, S. K., Diamond, B. J., Rausch, S., Kaufman, M., Shiflett, S. C., & Graves, L. (2006). The effect of Ginkgo biloba on functional measures in multiple sclerosis: a pilot randomized controlled trial. Explore (New York, N.Y.), 2(1), pp. 19-24.
Johnson SK, et al. The Effect of Ginkgo Biloba On Functional Measures in Multiple Sclerosis: a Pilot Randomized Controlled Trial. Explore (NY). 2006;2(1):19-24. PubMed PMID: 16781604.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of Ginkgo biloba on functional measures in multiple sclerosis: a pilot randomized controlled trial. AU - Johnson,Susan K, AU - Diamond,Bruce J, AU - Rausch,Sara, AU - Kaufman,Michael, AU - Shiflett,Samuel C, AU - Graves,Linda, PY - 2006/6/20/pubmed PY - 2006/9/13/medline PY - 2006/6/20/entrez SP - 19 EP - 24 JF - Explore (New York, N.Y.) JO - Explore (NY) VL - 2 IS - 1 N2 - BACKGROUND: Multiple sclerosis (MS) is a chronic demyelinating neurological disease afflicting young and middle-aged adults, resulting in problems with coordination, strength, cognition, affect, and sensation. OBJECTIVE: The objective of this study was to determine whether a ginkgo extract (EGb 761) improved functional performance in individuals with MS. DESIGN: This study used a double-blind, placebo-controlled, parallel group design. The end point was change between baseline (ie, preintervention) and follow-up evaluation following a regimen of four tablets per day at 60 mg per tablet for four weeks. SETTING: The study was conducted in academic and clinical-based settings. PATIENTS/PARTICIPANTS: Twenty-two individuals with MS were randomly assigned to either the treatment or control condition. Groups did not differ with respect to age, IQ, and education. INTERVENTION: Half of the subjects received 240 mg per day of ginkgo special extract (EGb 761), and the other half received placebo. MAIN OUTCOME MEASURE: The main outcome measures assessed depression (Center for Epidemiologic Studies of Depression Scale [CES-D]), anxiety (State-Trait Anxiety Inventory [STAI]), fatigue (Modified Fatigue Impact Scale [MFIS]); symptom severity (Symptom Inventory [SI]) and functional performance (Functional Assessment of Multiple Sclerosis [FAMS]). RESULTS: The ginkgo group had significantly more individuals showing improvement on four or more measures with improvements associated with significantly larger effect sizes on measures of fatigue, symptom severity, and functionality. The ginkgo group also exhibited less fatigue at follow-up compared with the placebo group. CONCLUSIONS: This exploratory pilot study showed that no adverse events or side effects were reported and that ginkgo exerted modest beneficial effects on select functional measures (eg, fatigue) among some individuals with MS. SN - 1550-8307 UR - https://www.unboundmedicine.com/medline/citation/16781604/The_effect_of_Ginkgo_biloba_on_functional_measures_in_multiple_sclerosis:_a_pilot_randomized_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1550-8307(05)00463-5 DB - PRIME DP - Unbound Medicine ER -