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Severe sepsis and septic shock: review of the literature and emergency department management guidelines.
Ann Emerg Med. 2006 Jul; 48(1):28-54.AE

Abstract

Severe sepsis and septic shock are as common and lethal as other acute life-threatening conditions that emergency physicians routinely confront such as acute myocardial infarction, stroke, and trauma. Recent studies have led to a better understanding of the pathogenic mechanisms and the development of new or newly applied therapies. These therapies place early and aggressive management of severe sepsis and septic shock as integral to improving outcome. This independent review of the literature examines the recent pathogenic, diagnostic, and therapeutic advances in severe sepsis and septic shock for adults, with particular relevance to emergency practice. Recommendations are provided for therapies that have been shown to improve outcomes, including early goal-directed therapy, early and appropriate antimicrobials, source control, recombinant human activated protein C, corticosteroids, and low tidal volume mechanical ventilation.

Authors+Show Affiliations

Nguyen HB
Loma Linda University, Loma Linda, CA, USA.
Rivers EP
No affiliation info available
Abrahamian FM
No affiliation info available
Moran GJ
No affiliation info available
Abraham E
No affiliation info available
Trzeciak S
No affiliation info available
Huang DT
No affiliation info available
Osborn T
No affiliation info available
Stevens D
No affiliation info available
Talan DA
No affiliation info available
Emergency Department Sepsis Education Program and Strategies to Improve Survival (ED-SEPSIS) Working Group
No affiliation info available

MeSH

Adrenal Cortex HormonesAlgorithmsAnti-Bacterial AgentsCardiovascular AgentsDrug Therapy, CombinationHumansPractice Guidelines as TopicProtein CRecombinant ProteinsRespiration, ArtificialSepsisShock, Septic

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16781920

Citation

Nguyen, H Bryant, et al. "Severe Sepsis and Septic Shock: Review of the Literature and Emergency Department Management Guidelines." Annals of Emergency Medicine, vol. 48, no. 1, 2006, pp. 28-54.
Nguyen HB, Rivers EP, Abrahamian FM, et al. Severe sepsis and septic shock: review of the literature and emergency department management guidelines. Ann Emerg Med. 2006;48(1):28-54.
Nguyen, H. B., Rivers, E. P., Abrahamian, F. M., Moran, G. J., Abraham, E., Trzeciak, S., Huang, D. T., Osborn, T., Stevens, D., & Talan, D. A. (2006). Severe sepsis and septic shock: review of the literature and emergency department management guidelines. Annals of Emergency Medicine, 48(1), 28-54.
Nguyen HB, et al. Severe Sepsis and Septic Shock: Review of the Literature and Emergency Department Management Guidelines. Ann Emerg Med. 2006;48(1):28-54. PubMed PMID: 16781920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe sepsis and septic shock: review of the literature and emergency department management guidelines. AU - Nguyen,H Bryant, AU - Rivers,Emanuel P, AU - Abrahamian,Fredrick M, AU - Moran,Gregory J, AU - Abraham,Edward, AU - Trzeciak,Stephen, AU - Huang,David T, AU - Osborn,Tiffany, AU - Stevens,Dennis, AU - Talan,David A, AU - ,, Y1 - 2006/05/02/ PY - 2005/07/06/received PY - 2006/01/20/revised PY - 2006/02/14/accepted PY - 2006/6/20/pubmed PY - 2006/6/29/medline PY - 2006/6/20/entrez SP - 28 EP - 54 JF - Annals of emergency medicine JO - Ann Emerg Med VL - 48 IS - 1 N2 - Severe sepsis and septic shock are as common and lethal as other acute life-threatening conditions that emergency physicians routinely confront such as acute myocardial infarction, stroke, and trauma. Recent studies have led to a better understanding of the pathogenic mechanisms and the development of new or newly applied therapies. These therapies place early and aggressive management of severe sepsis and septic shock as integral to improving outcome. This independent review of the literature examines the recent pathogenic, diagnostic, and therapeutic advances in severe sepsis and septic shock for adults, with particular relevance to emergency practice. Recommendations are provided for therapies that have been shown to improve outcomes, including early goal-directed therapy, early and appropriate antimicrobials, source control, recombinant human activated protein C, corticosteroids, and low tidal volume mechanical ventilation. SN - 1097-6760 UR - https://www.unboundmedicine.com/medline/citation/16781920/Severe_sepsis_and_septic_shock:_review_of_the_literature_and_emergency_department_management_guidelines_ DB - PRIME DP - Unbound Medicine ER -