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KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel.
Biochem Biophys Res Commun. 2006 Aug 04; 346(3):958-67.BB

Abstract

The mammalian Kv4.3 potassium channel is a fast activating and inactivating K+ channel widely distributed in mammalian tissues. Kv4.3 is the major component of various physiologically important currents ranging from A-type currents in the CNS to the transient outward potassium conductance in the heart (I(to)). Here we show that the KCNE3 beta-subunit has a strong inhibitory effect on current conducted by heterologously expressed Kv4.3 channels. KCNE3 reduces the Kv4.3 current amplitude, and it slows down the channel activation and inactivation as well as the recovery from inactivation. KCNE3 also inhibits currents generated by Kv4.3 in complex with the accessory subunit KChIP2. We find the inhibitory effect of KCNE3 to be specific for Kv4.3 within the Kv4 channel family. Kv4.3 has previously been shown to interact with a number of beta-subunits, but none of the described subunit-interactions exert an inhibitory effect on the Kv4.3 current.

Authors+Show Affiliations

The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Medical Physiology, University of Copenhagen, The Panum Institute, 3 Blegdamsvej, DK-2200 Copenhagen N, Denmark.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16782062

Citation

Lundby, Alicia, and Søren-Peter Olesen. "KCNE3 Is an Inhibitory Subunit of the Kv4.3 Potassium Channel." Biochemical and Biophysical Research Communications, vol. 346, no. 3, 2006, pp. 958-67.
Lundby A, Olesen SP. KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel. Biochem Biophys Res Commun. 2006;346(3):958-67.
Lundby, A., & Olesen, S. P. (2006). KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel. Biochemical and Biophysical Research Communications, 346(3), 958-67.
Lundby A, Olesen SP. KCNE3 Is an Inhibitory Subunit of the Kv4.3 Potassium Channel. Biochem Biophys Res Commun. 2006 Aug 4;346(3):958-67. PubMed PMID: 16782062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel. AU - Lundby,Alicia, AU - Olesen,Søren-Peter, Y1 - 2006/06/09/ PY - 2006/05/27/received PY - 2006/06/01/accepted PY - 2006/6/20/pubmed PY - 2006/8/22/medline PY - 2006/6/20/entrez SP - 958 EP - 67 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 346 IS - 3 N2 - The mammalian Kv4.3 potassium channel is a fast activating and inactivating K+ channel widely distributed in mammalian tissues. Kv4.3 is the major component of various physiologically important currents ranging from A-type currents in the CNS to the transient outward potassium conductance in the heart (I(to)). Here we show that the KCNE3 beta-subunit has a strong inhibitory effect on current conducted by heterologously expressed Kv4.3 channels. KCNE3 reduces the Kv4.3 current amplitude, and it slows down the channel activation and inactivation as well as the recovery from inactivation. KCNE3 also inhibits currents generated by Kv4.3 in complex with the accessory subunit KChIP2. We find the inhibitory effect of KCNE3 to be specific for Kv4.3 within the Kv4 channel family. Kv4.3 has previously been shown to interact with a number of beta-subunits, but none of the described subunit-interactions exert an inhibitory effect on the Kv4.3 current. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/16782062/KCNE3_is_an_inhibitory_subunit_of_the_Kv4_3_potassium_channel_ DB - PRIME DP - Unbound Medicine ER -