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Effects of high doses of recombinant human follicle-stimulating hormone in the treatment of male factor infertility: results of a pilot study.
Fertil Steril. 2006 Sep; 86(3):728-31.FS

Abstract

We performed a randomized double-blind placebo-controlled study on seminal parameters and endocrine profile of 30 normogonadotropic patients with male factor infertility to assess the efficacy of treatment with recombinant human FSH (rhFSH) at high doses (300 IU on alternate days) for a period of >or=4 months. The treatment induced a marked increase in sperm count, a slight increase in sperm motility, no change in sperm morphology, and an evident increase only in FSH serum levels, showing that a prolonged treatment with rhFSH at high doses led to an evident improvement of sperm count in normogonadotropic infertile patients with idiopathic oligoasthenozoospermia.

Authors+Show Affiliations

Department of Obstetrics and Gynecology and Reproductive Biology, University Alma Mater Studiorum of Bologna, Bologna, Italy. paradisi@med.unibo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16782097

Citation

Paradisi, Roberto, et al. "Effects of High Doses of Recombinant Human Follicle-stimulating Hormone in the Treatment of Male Factor Infertility: Results of a Pilot Study." Fertility and Sterility, vol. 86, no. 3, 2006, pp. 728-31.
Paradisi R, Busacchi P, Seracchioli R, et al. Effects of high doses of recombinant human follicle-stimulating hormone in the treatment of male factor infertility: results of a pilot study. Fertil Steril. 2006;86(3):728-31.
Paradisi, R., Busacchi, P., Seracchioli, R., Porcu, E., & Venturoli, S. (2006). Effects of high doses of recombinant human follicle-stimulating hormone in the treatment of male factor infertility: results of a pilot study. Fertility and Sterility, 86(3), 728-31.
Paradisi R, et al. Effects of High Doses of Recombinant Human Follicle-stimulating Hormone in the Treatment of Male Factor Infertility: Results of a Pilot Study. Fertil Steril. 2006;86(3):728-31. PubMed PMID: 16782097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of high doses of recombinant human follicle-stimulating hormone in the treatment of male factor infertility: results of a pilot study. AU - Paradisi,Roberto, AU - Busacchi,Paolo, AU - Seracchioli,Renato, AU - Porcu,Eleonora, AU - Venturoli,Stafano, Y1 - 2006/06/16/ PY - 2005/04/13/received PY - 2006/02/01/revised PY - 2006/02/01/accepted PY - 2006/6/20/pubmed PY - 2006/9/26/medline PY - 2006/6/20/entrez SP - 728 EP - 31 JF - Fertility and sterility JO - Fertil Steril VL - 86 IS - 3 N2 - We performed a randomized double-blind placebo-controlled study on seminal parameters and endocrine profile of 30 normogonadotropic patients with male factor infertility to assess the efficacy of treatment with recombinant human FSH (rhFSH) at high doses (300 IU on alternate days) for a period of >or=4 months. The treatment induced a marked increase in sperm count, a slight increase in sperm motility, no change in sperm morphology, and an evident increase only in FSH serum levels, showing that a prolonged treatment with rhFSH at high doses led to an evident improvement of sperm count in normogonadotropic infertile patients with idiopathic oligoasthenozoospermia. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/16782097/Effects_of_high_doses_of_recombinant_human_follicle_stimulating_hormone_in_the_treatment_of_male_factor_infertility:_results_of_a_pilot_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(06)00908-3 DB - PRIME DP - Unbound Medicine ER -