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RETRACTED ARTICLE

Radioprotective influence of Mentha piperita (Linn) against gamma irradiation in mice: Antioxidant and radical scavenging activity.
Int J Radiat Biol. 2006 May; 82(5):331-7.IJ

Abstract

PURPOSE

To evaluate the radiomodulatory influence of a leaf extract of Mentha piperita (Linn) on hepatic antioxidant status and lipid peroxidation in Swiss albino mice.

MATERIALS AND METHODS

Animals were given either double distilled water or leaf extract of M. piperita orally (1 g/kg bwt/day) once a day for three consecutive days. Thirty min after the last treatment mice were exposed to 8 Gy of gamma radiation. Mice were autopsied at 30 min post-irradiation. Biochemical parameters were studied to assess the radioprotective effect of leaf extract of M. piperita.

RESULTS

Animals pretreated with leaf extract of M. piperita and exposed to 8.0 Gy gamma radiation showed a significant increase in the activities of reduced glutathione content (p < 0.001), glutathione peroxidase (p < 0.005), glutathione reductase (p < 0.001), glutathione S-transferase (p < 0.005), superoxide dismutase (p < 0.005), and catalase (p < 0.005). Irradiated group pretreated with leaf extract of M. piperita showed significant decrease in malondialdehyde (MDA) formation in liver. The leaf extract of M. piperita showed strong radical scavenging activity in both the 1, 1 diphenyl-2-picryl hydrazyl radical (DPPH*) and 2, 2 azinobis (3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS*+) assays.

CONCLUSIONS

The results of the present investigation suggest the antioxidant and free radical scavenging activities of leaf extract of M. piperita are the likely mechanism of radiation protection.

Authors+Show Affiliations

Samarth RM
Radiation & Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India. rmsamarth@yahoo.co.in
Panwar M
No affiliation info available
Kumar M
No affiliation info available
Kumar A
No affiliation info available

MeSH

AnimalsAntioxidantsDose-Response Relationship, DrugDose-Response Relationship, RadiationFree Radical ScavengersGamma RaysLipid PeroxidationLiverMaleMentha piperitaMicePlant ExtractsPlant LeavesPlants, MedicinalRadiation-Protective AgentsWhole-Body Irradiation

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Retracted Publication

Language

eng

PubMed ID

16782650

Citation

Samarth, Ravindra M., et al. "Radioprotective Influence of Mentha Piperita (Linn) Against Gamma Irradiation in Mice: Antioxidant and Radical Scavenging Activity." International Journal of Radiation Biology, vol. 82, no. 5, 2006, pp. 331-7.
Samarth RM, Panwar M, Kumar M, et al. Radioprotective influence of Mentha piperita (Linn) against gamma irradiation in mice: Antioxidant and radical scavenging activity. Int J Radiat Biol. 2006;82(5):331-7.
Samarth, R. M., Panwar, M., Kumar, M., & Kumar, A. (2006). Radioprotective influence of Mentha piperita (Linn) against gamma irradiation in mice: Antioxidant and radical scavenging activity. International Journal of Radiation Biology, 82(5), 331-7.
Samarth RM, et al. Radioprotective Influence of Mentha Piperita (Linn) Against Gamma Irradiation in Mice: Antioxidant and Radical Scavenging Activity. Int J Radiat Biol. 2006;82(5):331-7. PubMed PMID: 16782650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Radioprotective influence of Mentha piperita (Linn) against gamma irradiation in mice: Antioxidant and radical scavenging activity. AU - Samarth,Ravindra M, AU - Panwar,Meenakshi, AU - Kumar,Madhu, AU - Kumar,Ashok, PY - 2006/6/20/pubmed PY - 2006/8/9/medline PY - 2006/6/20/entrez SP - 331 EP - 7 JF - International journal of radiation biology JO - Int J Radiat Biol VL - 82 IS - 5 N2 - PURPOSE: To evaluate the radiomodulatory influence of a leaf extract of Mentha piperita (Linn) on hepatic antioxidant status and lipid peroxidation in Swiss albino mice. MATERIALS AND METHODS: Animals were given either double distilled water or leaf extract of M. piperita orally (1 g/kg bwt/day) once a day for three consecutive days. Thirty min after the last treatment mice were exposed to 8 Gy of gamma radiation. Mice were autopsied at 30 min post-irradiation. Biochemical parameters were studied to assess the radioprotective effect of leaf extract of M. piperita. RESULTS: Animals pretreated with leaf extract of M. piperita and exposed to 8.0 Gy gamma radiation showed a significant increase in the activities of reduced glutathione content (p < 0.001), glutathione peroxidase (p < 0.005), glutathione reductase (p < 0.001), glutathione S-transferase (p < 0.005), superoxide dismutase (p < 0.005), and catalase (p < 0.005). Irradiated group pretreated with leaf extract of M. piperita showed significant decrease in malondialdehyde (MDA) formation in liver. The leaf extract of M. piperita showed strong radical scavenging activity in both the 1, 1 diphenyl-2-picryl hydrazyl radical (DPPH*) and 2, 2 azinobis (3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS*+) assays. CONCLUSIONS: The results of the present investigation suggest the antioxidant and free radical scavenging activities of leaf extract of M. piperita are the likely mechanism of radiation protection. SN - 0955-3002 UR - https://www.unboundmedicine.com/medline/citation/16782650/Radioprotective_influence_of_Mentha_piperita__Linn__against_gamma_irradiation_in_mice:_Antioxidant_and_radical_scavenging_activity_ DB - PRIME DP - Unbound Medicine ER -