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Efficacy of up-front treatment with a double stem cell transplantation in multiple myeloma.
Jpn J Clin Oncol. 2006 Jul; 36(7):432-8.JJ

Abstract

BACKGROUND

We report the outcome of 53 patients with multiple myeloma (MM), who received autologous stem cell transplantation (ASCT) from April 1996 to September 2004 at our institution and who survived for more than 3 months after the transplant.

METHODS

Following the first ASCT, 36 patients underwent an up-front second SCT, which consisted of either an ASCT (n = 24) or a reduced-intensity conditioning allogeneic stem cell transplant (RIST) (n = 12). Seventeen patients were given maintenance treatment.

RESULTS

Seventy-seven percent of the patients (n = 41) showed an objective response to the initial therapy prior to the first ASCT. Overall, 60.4% (32 out of 53) and 32.1% (17 out of 53) of the patients had a complete response (CR) and partial response (PR) after the first ASCT, respectively. At the time of analysis, 34 patients (64.2%) were still alive. With a median follow-up of 32 months (range 9-98), the estimated progression-free survival (PFS) and overall survival (OS) at 5 years were 17.0 and 34.9%, respectively. Multivariate analysis revealed that the second SCT, normal hemoglobin and <50% marrow plasma cells were associated with an improved PFS. A second SCT, CR to the first SCT, female gender and an absence of advanced bone lesions were associated with a better OS.

CONCLUSIONS

A second SCT is the most significant factor for an improved PFS and OS after the first ASCT (P < 0.001, respectively). Up-front double SCT is needed to improve the OS and PFS in patients with MM.

Authors+Show Affiliations

Catholic Hematopoietic Stem Cell Transplantation Center, St Mary's Hospital, Catholic University of Korea, Youngdungpo-Gu, Seoul 150-713, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16782727

Citation

Eom, Ki-Seong, et al. "Efficacy of Up-front Treatment With a Double Stem Cell Transplantation in Multiple Myeloma." Japanese Journal of Clinical Oncology, vol. 36, no. 7, 2006, pp. 432-8.
Eom KS, Min CK, Lee S, et al. Efficacy of up-front treatment with a double stem cell transplantation in multiple myeloma. Jpn J Clin Oncol. 2006;36(7):432-8.
Eom, K. S., Min, C. K., Lee, S., Kim, Y. J., Kim, S. Y., Kim, H. J., Lee, J. W., Min, W. S., & Kim, C. C. (2006). Efficacy of up-front treatment with a double stem cell transplantation in multiple myeloma. Japanese Journal of Clinical Oncology, 36(7), 432-8.
Eom KS, et al. Efficacy of Up-front Treatment With a Double Stem Cell Transplantation in Multiple Myeloma. Jpn J Clin Oncol. 2006;36(7):432-8. PubMed PMID: 16782727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of up-front treatment with a double stem cell transplantation in multiple myeloma. AU - Eom,Ki-Seong, AU - Min,Chang-Ki, AU - Lee,Seok, AU - Kim,Yoo-Jin, AU - Kim,Sung-Yong, AU - Kim,Hee-Je, AU - Lee,Jong-Wook, AU - Min,Woo-Sung, AU - Kim,Chun-Choo, Y1 - 2006/06/16/ PY - 2006/6/20/pubmed PY - 2006/9/23/medline PY - 2006/6/20/entrez SP - 432 EP - 8 JF - Japanese journal of clinical oncology JO - Jpn J Clin Oncol VL - 36 IS - 7 N2 - BACKGROUND: We report the outcome of 53 patients with multiple myeloma (MM), who received autologous stem cell transplantation (ASCT) from April 1996 to September 2004 at our institution and who survived for more than 3 months after the transplant. METHODS: Following the first ASCT, 36 patients underwent an up-front second SCT, which consisted of either an ASCT (n = 24) or a reduced-intensity conditioning allogeneic stem cell transplant (RIST) (n = 12). Seventeen patients were given maintenance treatment. RESULTS: Seventy-seven percent of the patients (n = 41) showed an objective response to the initial therapy prior to the first ASCT. Overall, 60.4% (32 out of 53) and 32.1% (17 out of 53) of the patients had a complete response (CR) and partial response (PR) after the first ASCT, respectively. At the time of analysis, 34 patients (64.2%) were still alive. With a median follow-up of 32 months (range 9-98), the estimated progression-free survival (PFS) and overall survival (OS) at 5 years were 17.0 and 34.9%, respectively. Multivariate analysis revealed that the second SCT, normal hemoglobin and <50% marrow plasma cells were associated with an improved PFS. A second SCT, CR to the first SCT, female gender and an absence of advanced bone lesions were associated with a better OS. CONCLUSIONS: A second SCT is the most significant factor for an improved PFS and OS after the first ASCT (P < 0.001, respectively). Up-front double SCT is needed to improve the OS and PFS in patients with MM. SN - 0368-2811 UR - https://www.unboundmedicine.com/medline/citation/16782727/Efficacy_of_up_front_treatment_with_a_double_stem_cell_transplantation_in_multiple_myeloma_ L2 - https://academic.oup.com/jjco/article-lookup/doi/10.1093/jjco/hyl041 DB - PRIME DP - Unbound Medicine ER -