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Recreational physical activity and prostate cancer risk (United States).
Cancer Causes Control 2006; 17(6):831-41CC

Abstract

OBJECTIVE

To examine recreational physical activity (PA) and prostate cancer risk in a large cohort of men living in Washington State, focusing on frequency and type of physical activity at various times throughout life.

METHODS

In a prospective cohort study, we assessed physical activity in 34,757 men (50-76 years at baseline) using a questionnaire. Men were recruited into the study between 2000 and 2002. Five hundred and eighty-three men developed prostate cancer.

RESULTS

Using Cox proportional hazards regression, PA either in the 10 years before baseline or earlier in life was not associated with prostate cancer risk. However, compared to no activity, >or=10.5 MET-h per week (the median level) of PA was associated with a reduced prostate cancer risk among men who were normal weight (HR = 0.69, 95% CI 0.46-1.0), >or=65 years at diagnosis (HR = 0.75, 95% CI 0.55-1.0) and who had not had a recent PSA (HR = 0.47, 95% CI 0.28-0.81). Greater PA was associated with an increased risk among men who were obese (HR = 1.5, 95% CI 0.95-2.4), and no association among men <65 years or with a recent history of PSA screening (all p for interactions <or=0.02).

CONCLUSIONS

PA was not associated with prostate cancer risk, except in subgroups defined by age, obesity, and screening history.

Authors+Show Affiliations

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4 B402, 19024, Seattle, WA 98109-1024, USA. alittman@fhcrc.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16783611

Citation

Littman, Alyson J., et al. "Recreational Physical Activity and Prostate Cancer Risk (United States)." Cancer Causes & Control : CCC, vol. 17, no. 6, 2006, pp. 831-41.
Littman AJ, Kristal AR, White E. Recreational physical activity and prostate cancer risk (United States). Cancer Causes Control. 2006;17(6):831-41.
Littman, A. J., Kristal, A. R., & White, E. (2006). Recreational physical activity and prostate cancer risk (United States). Cancer Causes & Control : CCC, 17(6), pp. 831-41.
Littman AJ, Kristal AR, White E. Recreational Physical Activity and Prostate Cancer Risk (United States). Cancer Causes Control. 2006;17(6):831-41. PubMed PMID: 16783611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recreational physical activity and prostate cancer risk (United States). AU - Littman,Alyson J, AU - Kristal,Alan R, AU - White,Emily, PY - 2005/11/08/received PY - 2006/03/14/accepted PY - 2006/6/20/pubmed PY - 2006/12/12/medline PY - 2006/6/20/entrez SP - 831 EP - 41 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 17 IS - 6 N2 - OBJECTIVE: To examine recreational physical activity (PA) and prostate cancer risk in a large cohort of men living in Washington State, focusing on frequency and type of physical activity at various times throughout life. METHODS: In a prospective cohort study, we assessed physical activity in 34,757 men (50-76 years at baseline) using a questionnaire. Men were recruited into the study between 2000 and 2002. Five hundred and eighty-three men developed prostate cancer. RESULTS: Using Cox proportional hazards regression, PA either in the 10 years before baseline or earlier in life was not associated with prostate cancer risk. However, compared to no activity, >or=10.5 MET-h per week (the median level) of PA was associated with a reduced prostate cancer risk among men who were normal weight (HR = 0.69, 95% CI 0.46-1.0), >or=65 years at diagnosis (HR = 0.75, 95% CI 0.55-1.0) and who had not had a recent PSA (HR = 0.47, 95% CI 0.28-0.81). Greater PA was associated with an increased risk among men who were obese (HR = 1.5, 95% CI 0.95-2.4), and no association among men <65 years or with a recent history of PSA screening (all p for interactions <or=0.02). CONCLUSIONS: PA was not associated with prostate cancer risk, except in subgroups defined by age, obesity, and screening history. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/16783611/Recreational_physical_activity_and_prostate_cancer_risk__United_States__ L2 - https://doi.org/10.1007/s10552-006-0024-8 DB - PRIME DP - Unbound Medicine ER -