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Nonlinear elastic and viscoelastic deformation of the human red blood cell with optical tweezers.
Mech Chem Biosyst 2004; 1(3):169-80MC

Abstract

Studies of the deformation characteristics of single biological cells can offer insights into the connections among mechanical state, biochemical response and the onset and progression of diseases. Deformation imposed by optical tweezers provides a useful means for the study of single cell mechanics under a variety of well-controlled stress-states. In this paper, we first critically review recent advances in the study of single cell mechanics employing the optical tweezers method, and assess its significance and limitations in comparison to other experimental tools. We then present new experimental and computational results on shape evolution, force-extension curves, elastic properties and viscoelastic response of human red blood cells subjected to large elastic deformation using optical tweezers. Potential applications of the methods examined here to study diseased cells are also briefly addressed.

Authors+Show Affiliations

Department of Materials Science and Engineering. National University of Singapore, Singapore 117576, Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16783930

Citation

Mills, J P., et al. "Nonlinear Elastic and Viscoelastic Deformation of the Human Red Blood Cell With Optical Tweezers." Mechanics & Chemistry of Biosystems : MCB, vol. 1, no. 3, 2004, pp. 169-80.
Mills JP, Qie L, Dao M, et al. Nonlinear elastic and viscoelastic deformation of the human red blood cell with optical tweezers. Mech Chem Biosyst. 2004;1(3):169-80.
Mills, J. P., Qie, L., Dao, M., Lim, C. T., & Suresh, S. (2004). Nonlinear elastic and viscoelastic deformation of the human red blood cell with optical tweezers. Mechanics & Chemistry of Biosystems : MCB, 1(3), pp. 169-80.
Mills JP, et al. Nonlinear Elastic and Viscoelastic Deformation of the Human Red Blood Cell With Optical Tweezers. Mech Chem Biosyst. 2004;1(3):169-80. PubMed PMID: 16783930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonlinear elastic and viscoelastic deformation of the human red blood cell with optical tweezers. AU - Mills,J P, AU - Qie,L, AU - Dao,M, AU - Lim,C T, AU - Suresh,S, PY - 2006/6/21/pubmed PY - 2006/7/6/medline PY - 2006/6/21/entrez SP - 169 EP - 80 JF - Mechanics & chemistry of biosystems : MCB JO - Mech Chem Biosyst VL - 1 IS - 3 N2 - Studies of the deformation characteristics of single biological cells can offer insights into the connections among mechanical state, biochemical response and the onset and progression of diseases. Deformation imposed by optical tweezers provides a useful means for the study of single cell mechanics under a variety of well-controlled stress-states. In this paper, we first critically review recent advances in the study of single cell mechanics employing the optical tweezers method, and assess its significance and limitations in comparison to other experimental tools. We then present new experimental and computational results on shape evolution, force-extension curves, elastic properties and viscoelastic response of human red blood cells subjected to large elastic deformation using optical tweezers. Potential applications of the methods examined here to study diseased cells are also briefly addressed. SN - 1546-2048 UR - https://www.unboundmedicine.com/medline/citation/16783930/Nonlinear_elastic_and_viscoelastic_deformation_of_the_human_red_blood_cell_with_optical_tweezers_ DB - PRIME DP - Unbound Medicine ER -