Tags

Type your tag names separated by a space and hit enter

Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma gene in women with polycystic ovary syndrome.
Gynecol Endocrinol. 2006 Jun; 22(6):336-42.GE

Abstract

AIM

The present study was designed to examine the relationship between Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma gene (PPAR-gamma) and clinical and hormonal characteristics in women with polycystic ovary syndrome (PCOS).

MATERIALS AND METHODS

One hundred patients with PCOS and 100 healthy subjects were included in the study. Serum levels of sex steroids were measured. Insulin resistance was evaluated by homeostasis model assessment (HOMA). The responses of glucose and insulin to an oral glucose tolerance test were analyzed by calculating the respective area under the curve (AUC) by the trapezoidal method. We used the restriction fragment length polymorphism technique and polymerase chain reaction to examine Pro12Ala polymorphism in exon 2 of PPAR-gamma.

RESULTS

Pro12Ala polymorphism of PPAR-gamma was significantly elevated in control subjects (22%) compared with PCOS subjects (15%). All of the Pro12Ala polymorphisms of PPAR-gamma were heterozygous. When PCOS subjects with the Pro allele and the Ala allele of PPAR-gamma were compared, the latter had lower free testosterone, androstenedione, dehydroepiandrosterone sulfate, insulin and C-peptide levels, as well as lower luteinizing hormone/follicle-stimulating hormone ratio, HOMA insulin resistance index, AUCinsulin, Ferriman-Gallwey score, acne, body mass index and waist-to-hip ratio.

CONCLUSION

We suggest that Pro12Ala polymorphism of the PPAR-gamma gene may be a modifier of insulin resistance in women with PCOS.

Authors+Show Affiliations

Kirikkale University Faculty of Medicine, Department of Endocrinology and Metabolism, Kirikkale, Turkey. murartt@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16785159

Citation

Yilmaz, Murat, et al. "Pro12Ala Polymorphism of the Peroxisome Proliferator-activated Receptor-gamma Gene in Women With Polycystic Ovary Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 22, no. 6, 2006, pp. 336-42.
Yilmaz M, Ergün MA, Karakoç A, et al. Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma gene in women with polycystic ovary syndrome. Gynecol Endocrinol. 2006;22(6):336-42.
Yilmaz, M., Ergün, M. A., Karakoç, A., Yurtçu, E., Cakir, N., & Arslan, M. (2006). Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma gene in women with polycystic ovary syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 22(6), 336-42.
Yilmaz M, et al. Pro12Ala Polymorphism of the Peroxisome Proliferator-activated Receptor-gamma Gene in Women With Polycystic Ovary Syndrome. Gynecol Endocrinol. 2006;22(6):336-42. PubMed PMID: 16785159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma gene in women with polycystic ovary syndrome. AU - Yilmaz,Murat, AU - Ergün,Mehmet Ali, AU - Karakoç,Ayhan, AU - Yurtçu,Erkan, AU - Cakir,Nuri, AU - Arslan,Metin, PY - 2006/6/21/pubmed PY - 2006/11/15/medline PY - 2006/6/21/entrez SP - 336 EP - 42 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 22 IS - 6 N2 - AIM: The present study was designed to examine the relationship between Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma gene (PPAR-gamma) and clinical and hormonal characteristics in women with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS: One hundred patients with PCOS and 100 healthy subjects were included in the study. Serum levels of sex steroids were measured. Insulin resistance was evaluated by homeostasis model assessment (HOMA). The responses of glucose and insulin to an oral glucose tolerance test were analyzed by calculating the respective area under the curve (AUC) by the trapezoidal method. We used the restriction fragment length polymorphism technique and polymerase chain reaction to examine Pro12Ala polymorphism in exon 2 of PPAR-gamma. RESULTS: Pro12Ala polymorphism of PPAR-gamma was significantly elevated in control subjects (22%) compared with PCOS subjects (15%). All of the Pro12Ala polymorphisms of PPAR-gamma were heterozygous. When PCOS subjects with the Pro allele and the Ala allele of PPAR-gamma were compared, the latter had lower free testosterone, androstenedione, dehydroepiandrosterone sulfate, insulin and C-peptide levels, as well as lower luteinizing hormone/follicle-stimulating hormone ratio, HOMA insulin resistance index, AUCinsulin, Ferriman-Gallwey score, acne, body mass index and waist-to-hip ratio. CONCLUSION: We suggest that Pro12Ala polymorphism of the PPAR-gamma gene may be a modifier of insulin resistance in women with PCOS. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/16785159/Pro12Ala_polymorphism_of_the_peroxisome_proliferator_activated_receptor_gamma_gene_in_women_with_polycystic_ovary_syndrome_ L2 - https://www.tandfonline.com/doi/full/10.1080/09513590600733357 DB - PRIME DP - Unbound Medicine ER -