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Induction of cystathionase in foetal rat liver explants. Effects of dexamethasone, N-6, O-2 -dibutyryladenosine 3,5 -monophosphate and glucagon in vitro.
Biochim Biophys Acta. 1975 Jul 14; 399(1):113-23.BB

Abstract

At the 18th day of gestation and thereafter foetal rat liver explants in organ culture showed the competence to respond to dexamethasone by increased cystathionase activity, whereas the ability to respond to dibutyryl cyclic AMP or glucagon became evident at a later developmental stage (during the last 2 days prior to term). Simultaneous incubation with cycloheximide inhibited the stimulatory effect of these agents on foetal rat liver cystathionase activity in vitro. Dexamethasone and glucagon were both capable of increasing liver cystathionase activity both in newborn and 3-day-old animals in vivo.

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Authors

Heinonen K
No affiliation info available

MeSH

AgingAnimalsBucladesineCycloheximideCystathionine gamma-LyaseDexamethasoneEnzyme InductionFemaleFetusGestational AgeGlucagonHydrocortisoneLiverLyasesOrgan Culture TechniquesPregnancyRatsTime Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

167857

Citation

Heinonen, K. "Induction of Cystathionase in Foetal Rat Liver Explants. Effects of Dexamethasone, N-6, O-2 -dibutyryladenosine 3,5 -monophosphate and Glucagon in Vitro." Biochimica Et Biophysica Acta, vol. 399, no. 1, 1975, pp. 113-23.
Heinonen K. Induction of cystathionase in foetal rat liver explants. Effects of dexamethasone, N-6, O-2 -dibutyryladenosine 3,5 -monophosphate and glucagon in vitro. Biochim Biophys Acta. 1975;399(1):113-23.
Heinonen, K. (1975). Induction of cystathionase in foetal rat liver explants. Effects of dexamethasone, N-6, O-2 -dibutyryladenosine 3,5 -monophosphate and glucagon in vitro. Biochimica Et Biophysica Acta, 399(1), 113-23.
Heinonen K. Induction of Cystathionase in Foetal Rat Liver Explants. Effects of Dexamethasone, N-6, O-2 -dibutyryladenosine 3,5 -monophosphate and Glucagon in Vitro. Biochim Biophys Acta. 1975 Jul 14;399(1):113-23. PubMed PMID: 167857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Induction of cystathionase in foetal rat liver explants. Effects of dexamethasone, N-6, O-2 -dibutyryladenosine 3,5 -monophosphate and glucagon in vitro. A1 - Heinonen,K, PY - 1975/7/14/pubmed PY - 1975/7/14/medline PY - 1975/7/14/entrez SP - 113 EP - 23 JF - Biochimica et biophysica acta JO - Biochim Biophys Acta VL - 399 IS - 1 N2 - At the 18th day of gestation and thereafter foetal rat liver explants in organ culture showed the competence to respond to dexamethasone by increased cystathionase activity, whereas the ability to respond to dibutyryl cyclic AMP or glucagon became evident at a later developmental stage (during the last 2 days prior to term). Simultaneous incubation with cycloheximide inhibited the stimulatory effect of these agents on foetal rat liver cystathionase activity in vitro. Dexamethasone and glucagon were both capable of increasing liver cystathionase activity both in newborn and 3-day-old animals in vivo. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/167857/Induction_of_cystathionase_in_foetal_rat_liver_explants__Effects_of_dexamethasone_N_6_O_2__dibutyryladenosine_35__monophosphate_and_glucagon_in_vitro_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0304-4165(75)90217-2 DB - PRIME DP - Unbound Medicine ER -