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Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues.
Mol Cell Biochem. 2006 Dec; 293(1-2):211-9.MC

Abstract

Rutin, a polyphenolic flavonoid, was investigated for its antioxidant potential in streptozotocin (STZ)-induced diabetic rats. Rats were rendered diabetic by a single intraperitoneal injection of streptozotocin (50 mg/kg). The levels of fasting plasma glucose and insulin were estimated. Lipid peroxidative products and antioxidants were estimated in liver, kidney and brain. Histopathological studies were carried out in these tissues. A significant (p < 0.05) increase in the levels of fasting plasma glucose, lipid peroxidative products (thiobarbituric acid reactive substances [TBARS] and lipid hydroperoxides [HP]) and a significant (p < 0.05) decrease in plasma insulin, enzymic antioxidants (superoxide dismutase [SOD], catalase, glutathione peroxidase [GPx] and glutathione reductase [GRx]) and nonenzymic antioxidants (reduced glutathione [GSH], vitamin C and E) in diabetic liver, kidney and brain were observed. Oral administration of rutin (100 mg/kg) for a period of 45 days significantly (p < 0.05) decreased fasting plasma glucose, increased insulin levels and improved the antioxidant status of diabetic rats by decreasing lipid peroxidative products and increasing enzymic and nonenzymic antioxidants. Normal rats treated with rutin (100 mg/kg) showed no significant (p < 0.05) effect on any of the parameters studied. Histopathological studies of the liver, kidney and brain showed the protective role of rutin. Thus, our study clearly shows that rutin has antioxidant effect in STZ-induced experimental diabetes.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar-608 002, Tamilnadu, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16786186

Citation

Kamalakkannan, N, and P Stanely Mainzen Prince. "Rutin Improves the Antioxidant Status in Streptozotocin-induced Diabetic Rat Tissues." Molecular and Cellular Biochemistry, vol. 293, no. 1-2, 2006, pp. 211-9.
Kamalakkannan N, Stanely Mainzen Prince P. Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues. Mol Cell Biochem. 2006;293(1-2):211-9.
Kamalakkannan, N., & Stanely Mainzen Prince, P. (2006). Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues. Molecular and Cellular Biochemistry, 293(1-2), 211-9.
Kamalakkannan N, Stanely Mainzen Prince P. Rutin Improves the Antioxidant Status in Streptozotocin-induced Diabetic Rat Tissues. Mol Cell Biochem. 2006;293(1-2):211-9. PubMed PMID: 16786186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues. AU - Kamalakkannan,N, AU - Stanely Mainzen Prince,P, Y1 - 2006/06/20/ PY - 2006/02/24/received PY - 2006/05/16/accepted PY - 2006/6/21/pubmed PY - 2007/3/17/medline PY - 2006/6/21/entrez SP - 211 EP - 9 JF - Molecular and cellular biochemistry JO - Mol Cell Biochem VL - 293 IS - 1-2 N2 - Rutin, a polyphenolic flavonoid, was investigated for its antioxidant potential in streptozotocin (STZ)-induced diabetic rats. Rats were rendered diabetic by a single intraperitoneal injection of streptozotocin (50 mg/kg). The levels of fasting plasma glucose and insulin were estimated. Lipid peroxidative products and antioxidants were estimated in liver, kidney and brain. Histopathological studies were carried out in these tissues. A significant (p < 0.05) increase in the levels of fasting plasma glucose, lipid peroxidative products (thiobarbituric acid reactive substances [TBARS] and lipid hydroperoxides [HP]) and a significant (p < 0.05) decrease in plasma insulin, enzymic antioxidants (superoxide dismutase [SOD], catalase, glutathione peroxidase [GPx] and glutathione reductase [GRx]) and nonenzymic antioxidants (reduced glutathione [GSH], vitamin C and E) in diabetic liver, kidney and brain were observed. Oral administration of rutin (100 mg/kg) for a period of 45 days significantly (p < 0.05) decreased fasting plasma glucose, increased insulin levels and improved the antioxidant status of diabetic rats by decreasing lipid peroxidative products and increasing enzymic and nonenzymic antioxidants. Normal rats treated with rutin (100 mg/kg) showed no significant (p < 0.05) effect on any of the parameters studied. Histopathological studies of the liver, kidney and brain showed the protective role of rutin. Thus, our study clearly shows that rutin has antioxidant effect in STZ-induced experimental diabetes. SN - 0300-8177 UR - https://www.unboundmedicine.com/medline/citation/16786186/Rutin_improves_the_antioxidant_status_in_streptozotocin_induced_diabetic_rat_tissues_ L2 - https://doi.org/10.1007/s11010-006-9244-1 DB - PRIME DP - Unbound Medicine ER -