Tags

Type your tag names separated by a space and hit enter

Capillary electrophoresis for the analysis of small-molecule pharmaceuticals.
Electrophoresis. 2006 Jun; 27(12):2263-82.E

Abstract

This paper reviews the application of CE to the analysis of small-molecule pharmaceuticals. The areas of pharmaceutical analysis covered are enantiomer separation, the analysis of small molecules such as amino acids or drug counter-ions, pharmaceutical assay, determination of related substances and physicochemical measurements such as log P and pK(a) of compounds. The different electrophoretic modes available and their advantages for pharmaceutical analysis are described. Recent applications of CE for each subject area are tabulated with electrolyte details.

Authors+Show Affiliations

Altria K
GlaxoSmithKline Research & Development, Harlow, Essex, UK. kevin.d.altria@gsk.com
Marsh A
No affiliation info available
Sänger-van de Griend C
No affiliation info available

MeSH

ChromatographyDrug ContaminationElectrophoresis, CapillaryHydrogen-Ion ConcentrationPharmaceutical PreparationsStereoisomerism

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16786477

Citation

Altria, Kevin, et al. "Capillary Electrophoresis for the Analysis of Small-molecule Pharmaceuticals." Electrophoresis, vol. 27, no. 12, 2006, pp. 2263-82.
Altria K, Marsh A, Sänger-van de Griend C. Capillary electrophoresis for the analysis of small-molecule pharmaceuticals. Electrophoresis. 2006;27(12):2263-82.
Altria, K., Marsh, A., & Sänger-van de Griend, C. (2006). Capillary electrophoresis for the analysis of small-molecule pharmaceuticals. Electrophoresis, 27(12), 2263-82.
Altria K, Marsh A, Sänger-van de Griend C. Capillary Electrophoresis for the Analysis of Small-molecule Pharmaceuticals. Electrophoresis. 2006;27(12):2263-82. PubMed PMID: 16786477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Capillary electrophoresis for the analysis of small-molecule pharmaceuticals. AU - Altria,Kevin, AU - Marsh,Alex, AU - Sänger-van de Griend,Cari, PY - 2006/6/21/pubmed PY - 2006/9/14/medline PY - 2006/6/21/entrez SP - 2263 EP - 82 JF - Electrophoresis JO - Electrophoresis VL - 27 IS - 12 N2 - This paper reviews the application of CE to the analysis of small-molecule pharmaceuticals. The areas of pharmaceutical analysis covered are enantiomer separation, the analysis of small molecules such as amino acids or drug counter-ions, pharmaceutical assay, determination of related substances and physicochemical measurements such as log P and pK(a) of compounds. The different electrophoretic modes available and their advantages for pharmaceutical analysis are described. Recent applications of CE for each subject area are tabulated with electrolyte details. SN - 0173-0835 UR - https://www.unboundmedicine.com/medline/citation/16786477/Capillary_electrophoresis_for_the_analysis_of_small_molecule_pharmaceuticals_ L2 - https://doi.org/10.1002/elps.200600030 DB - PRIME DP - Unbound Medicine ER -