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Fortification of milk with calcium: effect on calcium bioavailability and interactions with iron and zinc.
J Agric Food Chem. 2006 Jun 28; 54(13):4901-6.JA

Abstract

Calcium solubility, dialysability, and transport and uptake (retention + transport) by Caco-2 cells as indicators of calcium bioavailability have been estimated in the in vitro gastrointestinal digests of milk and calcium fortified milk. A significant linear correlation (p < 0.05) was obtained between calcium uptake and the amount of soluble calcium added to the cells, and also between percentage calcium uptake and the calcium measured in the analyzed samples. The solubility, dialysis, transport, and uptake values are higher (p < 0.05) for calcium fortified milks than for nonfortified milks; that is, calcium fortification increases not only calcium content but also its bioavailability. An inhibitory effect of calcium from fortified milks upon iron absorption was found. The observed effect of calcium from fortified milks upon zinc bioavailability depends on the in vitro method used, zinc solubility and dialysis decrease in calcium fortified milks, and percentage zinc uptake remains unchanged.

Authors+Show Affiliations

Perales S
Nutrition and Food Chemistry, Faculty of Pharmacy, University of Valencia, Avda. Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.
Barberá R
No affiliation info available
Lagarda MJ
No affiliation info available
Farré R
No affiliation info available

MeSH

AnimalsBiological AvailabilityBiological TransportCalciumDrug InteractionsFood, FortifiedIronMilkSolubilityZinc

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16787046

Citation

Perales, Sara, et al. "Fortification of Milk With Calcium: Effect On Calcium Bioavailability and Interactions With Iron and Zinc." Journal of Agricultural and Food Chemistry, vol. 54, no. 13, 2006, pp. 4901-6.
Perales S, Barberá R, Lagarda MJ, et al. Fortification of milk with calcium: effect on calcium bioavailability and interactions with iron and zinc. J Agric Food Chem. 2006;54(13):4901-6.
Perales, S., Barberá, R., Lagarda, M. J., & Farré, R. (2006). Fortification of milk with calcium: effect on calcium bioavailability and interactions with iron and zinc. Journal of Agricultural and Food Chemistry, 54(13), 4901-6.
Perales S, et al. Fortification of Milk With Calcium: Effect On Calcium Bioavailability and Interactions With Iron and Zinc. J Agric Food Chem. 2006 Jun 28;54(13):4901-6. PubMed PMID: 16787046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fortification of milk with calcium: effect on calcium bioavailability and interactions with iron and zinc. AU - Perales,Sara, AU - Barberá,Reyes, AU - Lagarda,María Jesús, AU - Farré,Rosaura, PY - 2006/6/22/pubmed PY - 2006/8/11/medline PY - 2006/6/22/entrez SP - 4901 EP - 6 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 54 IS - 13 N2 - Calcium solubility, dialysability, and transport and uptake (retention + transport) by Caco-2 cells as indicators of calcium bioavailability have been estimated in the in vitro gastrointestinal digests of milk and calcium fortified milk. A significant linear correlation (p < 0.05) was obtained between calcium uptake and the amount of soluble calcium added to the cells, and also between percentage calcium uptake and the calcium measured in the analyzed samples. The solubility, dialysis, transport, and uptake values are higher (p < 0.05) for calcium fortified milks than for nonfortified milks; that is, calcium fortification increases not only calcium content but also its bioavailability. An inhibitory effect of calcium from fortified milks upon iron absorption was found. The observed effect of calcium from fortified milks upon zinc bioavailability depends on the in vitro method used, zinc solubility and dialysis decrease in calcium fortified milks, and percentage zinc uptake remains unchanged. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/16787046/Fortification_of_milk_with_calcium:_effect_on_calcium_bioavailability_and_interactions_with_iron_and_zinc_ L2 - https://doi.org/10.1021/jf0601214 DB - PRIME DP - Unbound Medicine ER -