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Irritants in combination with a synergistic or additive effect on the skin response: an overview of tandem irritation studies.
Contact Dermatitis. 2006 Jun; 54(6):303-12.CD

Abstract

Sodium lauryl sulfate (SLS) has often been chosen as a model for irritant contact dermatitis (ICD) to study the effect of irritants in combination (1-14). Recently 'tandem', or sequential, exposures with SLS have been performed to study the mechanism of skin barrier impairment in ICD (1-6, 15). The assessment of reactions have been documented with visual scoring, transepidermal water loss (TEWL), skin colour reflectance measurements, skin blood flow; among which TEWL has been noted as the most sensitive value (16). The matched control groups were treated with either a single exposure to a single irritant or in tandem with the same irritant repeatedly. Synergistic and additive effects have been reported for various tandem pairs of irritants, however, the mechanism for both remains unclear. The results of tandem irritation studies were evaluated to define and investigate the responses produced and deduce a possible mechanism of action. Clinical ramifications, albeit complex, are discussed.

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Authors+Show Affiliations

Kartono F
Department of Dermatology, UCSF, School of Medicine, San Francisco, CA 94143, USA.
Maibach HI
No affiliation info available

MeSH

Air MovementsDermatitis, IrritantDrug SynergismHumansHydrogen-Ion ConcentrationIrritantsPermeabilitySkin Irritancy TestsSodium Dodecyl SulfateStress, MechanicalTemperature

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16787451

Citation

Kartono, Francisca, and H I. Maibach. "Irritants in Combination With a Synergistic or Additive Effect On the Skin Response: an Overview of Tandem Irritation Studies." Contact Dermatitis, vol. 54, no. 6, 2006, pp. 303-12.
Kartono F, Maibach HI. Irritants in combination with a synergistic or additive effect on the skin response: an overview of tandem irritation studies. Contact Dermatitis. 2006;54(6):303-12.
Kartono, F., & Maibach, H. I. (2006). Irritants in combination with a synergistic or additive effect on the skin response: an overview of tandem irritation studies. Contact Dermatitis, 54(6), 303-12.
Kartono F, Maibach HI. Irritants in Combination With a Synergistic or Additive Effect On the Skin Response: an Overview of Tandem Irritation Studies. Contact Dermatitis. 2006;54(6):303-12. PubMed PMID: 16787451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Irritants in combination with a synergistic or additive effect on the skin response: an overview of tandem irritation studies. AU - Kartono,Francisca, AU - Maibach,H I, PY - 2006/6/22/pubmed PY - 2006/11/10/medline PY - 2006/6/22/entrez SP - 303 EP - 12 JF - Contact dermatitis JO - Contact Dermatitis VL - 54 IS - 6 N2 - Sodium lauryl sulfate (SLS) has often been chosen as a model for irritant contact dermatitis (ICD) to study the effect of irritants in combination (1-14). Recently 'tandem', or sequential, exposures with SLS have been performed to study the mechanism of skin barrier impairment in ICD (1-6, 15). The assessment of reactions have been documented with visual scoring, transepidermal water loss (TEWL), skin colour reflectance measurements, skin blood flow; among which TEWL has been noted as the most sensitive value (16). The matched control groups were treated with either a single exposure to a single irritant or in tandem with the same irritant repeatedly. Synergistic and additive effects have been reported for various tandem pairs of irritants, however, the mechanism for both remains unclear. The results of tandem irritation studies were evaluated to define and investigate the responses produced and deduce a possible mechanism of action. Clinical ramifications, albeit complex, are discussed. SN - 0105-1873 UR - https://www.unboundmedicine.com/medline/citation/16787451/Irritants_in_combination_with_a_synergistic_or_additive_effect_on_the_skin_response:_an_overview_of_tandem_irritation_studies_ L2 - https://doi.org/10.1111/j.0105-1873.2006.00792.x DB - PRIME DP - Unbound Medicine ER -