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Effect of disease-related pain on the health-related quality of life of children and adolescents with cystic fibrosis.
Clin J Pain. 2006 Jul-Aug; 22(6):532-7.CJ

Abstract

OBJECTIVES

The authors' objective was to describe the effect of recurrent pain symptoms on the health-related quality of life (HRQOL) of children and adolescents with cystic fibrosis (CF). Frequent pain, independent of disease severity, was hypothesized to be associated with broad decrements in physical, psychological, and social functioning.

METHODS

Forty-six children and adolescents (mean age 12.9 years; 52% female) completed the Cystic Fibrosis Questionnaire-Revised (CFQ-R) to assess their HRQOL and a retrospective pain interview to assess pain location, frequency, intensity, duration, and bother during a routine clinic visit. Forced expiratory volume in 1 second as percent of predicted (FEV1%) was recorded from medical charts to assess the children's disease severity.

RESULTS

As hypothesized, pain symptoms were related to children's physical, emotional, and role functioning, CF-related symptoms, and overall perception of their health. Children with frequent pain had significantly reduced physical functioning, vitality, role limitations, and overall perceptions of their health, and increased eating disturbances, treatment burden, respiratory, and digestive symptoms compared with children with no pain or less frequent pain. After controlling for the effects of disease severity, pain frequency continued to predict children's HRQOL in each of these areas.

DISCUSSION

Children with frequent CF-related pain experienced broad decrements in their HRQOL. These findings are similar to those found in other populations of children experiencing disease-related pain, suggesting a pervasive impact of pain on overall health and well-being. Future research is needed to evaluate treatments to reduce pain symptoms and improve HRQOL in children with cystic fibrosis.

Authors+Show Affiliations

Department of Anesthesiology & Peri-Operative Medicine, Oregon Health & Science University, Doernbecher Children's Hospital, Portland, OR 97239, USA. palermot@ohsu.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16788339

Citation

Palermo, Tonya M., et al. "Effect of Disease-related Pain On the Health-related Quality of Life of Children and Adolescents With Cystic Fibrosis." The Clinical Journal of Pain, vol. 22, no. 6, 2006, pp. 532-7.
Palermo TM, Harrison D, Koh JL. Effect of disease-related pain on the health-related quality of life of children and adolescents with cystic fibrosis. Clin J Pain. 2006;22(6):532-7.
Palermo, T. M., Harrison, D., & Koh, J. L. (2006). Effect of disease-related pain on the health-related quality of life of children and adolescents with cystic fibrosis. The Clinical Journal of Pain, 22(6), 532-7.
Palermo TM, Harrison D, Koh JL. Effect of Disease-related Pain On the Health-related Quality of Life of Children and Adolescents With Cystic Fibrosis. Clin J Pain. 2006 Jul-Aug;22(6):532-7. PubMed PMID: 16788339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of disease-related pain on the health-related quality of life of children and adolescents with cystic fibrosis. AU - Palermo,Tonya M, AU - Harrison,Dale, AU - Koh,Jeffrey L, PY - 2006/6/22/pubmed PY - 2006/8/26/medline PY - 2006/6/22/entrez SP - 532 EP - 7 JF - The Clinical journal of pain JO - Clin J Pain VL - 22 IS - 6 N2 - OBJECTIVES: The authors' objective was to describe the effect of recurrent pain symptoms on the health-related quality of life (HRQOL) of children and adolescents with cystic fibrosis (CF). Frequent pain, independent of disease severity, was hypothesized to be associated with broad decrements in physical, psychological, and social functioning. METHODS: Forty-six children and adolescents (mean age 12.9 years; 52% female) completed the Cystic Fibrosis Questionnaire-Revised (CFQ-R) to assess their HRQOL and a retrospective pain interview to assess pain location, frequency, intensity, duration, and bother during a routine clinic visit. Forced expiratory volume in 1 second as percent of predicted (FEV1%) was recorded from medical charts to assess the children's disease severity. RESULTS: As hypothesized, pain symptoms were related to children's physical, emotional, and role functioning, CF-related symptoms, and overall perception of their health. Children with frequent pain had significantly reduced physical functioning, vitality, role limitations, and overall perceptions of their health, and increased eating disturbances, treatment burden, respiratory, and digestive symptoms compared with children with no pain or less frequent pain. After controlling for the effects of disease severity, pain frequency continued to predict children's HRQOL in each of these areas. DISCUSSION: Children with frequent CF-related pain experienced broad decrements in their HRQOL. These findings are similar to those found in other populations of children experiencing disease-related pain, suggesting a pervasive impact of pain on overall health and well-being. Future research is needed to evaluate treatments to reduce pain symptoms and improve HRQOL in children with cystic fibrosis. SN - 0749-8047 UR - https://www.unboundmedicine.com/medline/citation/16788339/Effect_of_disease_related_pain_on_the_health_related_quality_of_life_of_children_and_adolescents_with_cystic_fibrosis_ L2 - https://doi.org/10.1097/01.ajp.0000210996.45459.76 DB - PRIME DP - Unbound Medicine ER -