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Diterpenoids from the roots of Euphorbia fischeriana.
J Nat Prod. 2006 Jun; 69(6):967-70.JN

Abstract

From the dried roots of Euphorbia fischeriana, seven new diterpenoids, 3alpha,17-dihydroxy-ent-pimara-8(14),15-diene (1), 7beta,11beta,12beta-trihydroxy-ent-abieta-8(14),13(15)-dien-16,12-olide (2), 17-acetoxyjolkinolide B (3), 13beta-hydroxy-ent-abiet-8(14)-en-7-one (4), 12-deoxyphorbaldehyde-13-acetate (5) 12-deoxyphorbaldehyde-13-hexadecacetate (6), and 12-deoxyphorbol-13-(9Z)-octadecanoate-20-acetate (7), and two known compounds, 12-deoxyphorbol-13-decanoate (8) and prostratin (9), were isolated. The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The structure of compound 1 was confirmed by single-crystal X-ray crystallography. Compounds 3 and 8 exhibited potent cytotoxic activity to Ramos B cells with IC50 values of 0.023 and 0.0051 microg/mL, respectively.

Authors+Show Affiliations

Wang YB
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
Huang R
No affiliation info available
Wang HB
No affiliation info available
Jin HZ
No affiliation info available
Lou LG
No affiliation info available
Qin GW
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicBurkitt LymphomaDiterpenesDrug Screening Assays, AntitumorDrugs, Chinese HerbalEuphorbiaHumansMolecular StructurePlant RootsPlants, MedicinalTumor Cells, Cultured

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16792421

Citation

Wang, Yu-Bo, et al. "Diterpenoids From the Roots of Euphorbia Fischeriana." Journal of Natural Products, vol. 69, no. 6, 2006, pp. 967-70.
Wang YB, Huang R, Wang HB, et al. Diterpenoids from the roots of Euphorbia fischeriana. J Nat Prod. 2006;69(6):967-70.
Wang, Y. B., Huang, R., Wang, H. B., Jin, H. Z., Lou, L. G., & Qin, G. W. (2006). Diterpenoids from the roots of Euphorbia fischeriana. Journal of Natural Products, 69(6), 967-70.
Wang YB, et al. Diterpenoids From the Roots of Euphorbia Fischeriana. J Nat Prod. 2006;69(6):967-70. PubMed PMID: 16792421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diterpenoids from the roots of Euphorbia fischeriana. AU - Wang,Yu-Bo, AU - Huang,Rong, AU - Wang,Hong-Bing, AU - Jin,Hui-Zi, AU - Lou,Li-Guang, AU - Qin,Guo-Wei, PY - 2006/6/24/pubmed PY - 2006/8/1/medline PY - 2006/6/24/entrez SP - 967 EP - 70 JF - Journal of natural products JO - J Nat Prod VL - 69 IS - 6 N2 - From the dried roots of Euphorbia fischeriana, seven new diterpenoids, 3alpha,17-dihydroxy-ent-pimara-8(14),15-diene (1), 7beta,11beta,12beta-trihydroxy-ent-abieta-8(14),13(15)-dien-16,12-olide (2), 17-acetoxyjolkinolide B (3), 13beta-hydroxy-ent-abiet-8(14)-en-7-one (4), 12-deoxyphorbaldehyde-13-acetate (5) 12-deoxyphorbaldehyde-13-hexadecacetate (6), and 12-deoxyphorbol-13-(9Z)-octadecanoate-20-acetate (7), and two known compounds, 12-deoxyphorbol-13-decanoate (8) and prostratin (9), were isolated. The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The structure of compound 1 was confirmed by single-crystal X-ray crystallography. Compounds 3 and 8 exhibited potent cytotoxic activity to Ramos B cells with IC50 values of 0.023 and 0.0051 microg/mL, respectively. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/16792421/Diterpenoids_from_the_roots_of_Euphorbia_fischeriana_ L2 - https://doi.org/10.1021/np0600088 DB - PRIME DP - Unbound Medicine ER -