Tags

Type your tag names separated by a space and hit enter

Percutaneous penetration of sodium lauryl sulphate is increased in uninvolved skin of patients with atopic dermatitis compared with control subjects.
Br J Dermatol. 2006 Jul; 155(1):104-9.BJ

Abstract

BACKGROUND

Involved regions of the skin in patients with atopic dermatitis (AD) have been shown to have higher transepidermal water loss (TEWL), indicating a compromised skin barrier. Whether uninvolved skin also has diminished barrier characteristics is controversial.

OBJECTIVES

To study the penetration of sodium lauryl sulphate (SLS) into uninvolved skin of patients with AD compared with the skin of control subjects.

METHODS

Percutaneous penetration was assessed using the tape stripping technique on the stratum corneum (SC). Twenty patients with AD and 20 healthy subjects were exposed to 1% SLS for 4 h on the mid-volar forearm. After the end of exposure the SC was removed by adhesive tape. The amount of SLS was determined in each consecutive strip. Fick's second law of diffusion was used to deduce the diffusivity and the partition coefficient of SLS between water and the SC.

RESULTS

The SC thickness was similar in both groups; however, the TEWL was higher in patients with AD compared with that of the control group (mean+/-SD 8.4+/-4.3 and 6.3+/-2.0 g m-2 h-1, respectively). There was a correlation between SC thickness and TEWL in control subjects but no correlation was found in patients with AD. The diffusivity of SLS through uninvolved AD skin was higher compared with normal skin (mean+/-SD 12.7+/-5.8x10(-9) and 6.2+/-3.0x10(-9) cm-2 h-1, respectively), while the partition coefficient between SC and water was lower (mean+/-SD 137+/-64 and 196+/-107, respectively).

CONCLUSIONS

The results show a different penetration profile of SLS into the SC of patients with AD compared with control subjects. This indicates that even noninvolved skin in patients with AD has altered barrier characteristics, emphasizing the importance of skin protection and prevention of skin contact with chemicals.

Links

Aggregator Full Text

Authors+Show Affiliations

Jakasa I
Coronel Institute of Occupational Health, Research Institute AmCOGG, Academic Medical Center, University of Amsterdam, PO Box 22770, 1100 DE Amsterdam, the Netherlands. i.jakasa@amc.uva.nl
de Jongh CM
No affiliation info available
Verberk MM
No affiliation info available
Bos JD
No affiliation info available
Kezić S
No affiliation info available

MeSH

AdolescentAdultCase-Control StudiesDermatitis, AtopicFemaleHumansMaleMiddle AgedSkin AbsorptionSodium Dodecyl SulfateSurface-Active AgentsWater Loss, Insensible

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16792760

Citation

Jakasa, I, et al. "Percutaneous Penetration of Sodium Lauryl Sulphate Is Increased in Uninvolved Skin of Patients With Atopic Dermatitis Compared With Control Subjects." The British Journal of Dermatology, vol. 155, no. 1, 2006, pp. 104-9.
Jakasa I, de Jongh CM, Verberk MM, et al. Percutaneous penetration of sodium lauryl sulphate is increased in uninvolved skin of patients with atopic dermatitis compared with control subjects. Br J Dermatol. 2006;155(1):104-9.
Jakasa, I., de Jongh, C. M., Verberk, M. M., Bos, J. D., & Kezić, S. (2006). Percutaneous penetration of sodium lauryl sulphate is increased in uninvolved skin of patients with atopic dermatitis compared with control subjects. The British Journal of Dermatology, 155(1), 104-9.
Jakasa I, et al. Percutaneous Penetration of Sodium Lauryl Sulphate Is Increased in Uninvolved Skin of Patients With Atopic Dermatitis Compared With Control Subjects. Br J Dermatol. 2006;155(1):104-9. PubMed PMID: 16792760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Percutaneous penetration of sodium lauryl sulphate is increased in uninvolved skin of patients with atopic dermatitis compared with control subjects. AU - Jakasa,I, AU - de Jongh,C M, AU - Verberk,M M, AU - Bos,J D, AU - Kezić,S, PY - 2006/6/24/pubmed PY - 2006/10/18/medline PY - 2006/6/24/entrez SP - 104 EP - 9 JF - The British journal of dermatology JO - Br J Dermatol VL - 155 IS - 1 N2 - BACKGROUND: Involved regions of the skin in patients with atopic dermatitis (AD) have been shown to have higher transepidermal water loss (TEWL), indicating a compromised skin barrier. Whether uninvolved skin also has diminished barrier characteristics is controversial. OBJECTIVES: To study the penetration of sodium lauryl sulphate (SLS) into uninvolved skin of patients with AD compared with the skin of control subjects. METHODS: Percutaneous penetration was assessed using the tape stripping technique on the stratum corneum (SC). Twenty patients with AD and 20 healthy subjects were exposed to 1% SLS for 4 h on the mid-volar forearm. After the end of exposure the SC was removed by adhesive tape. The amount of SLS was determined in each consecutive strip. Fick's second law of diffusion was used to deduce the diffusivity and the partition coefficient of SLS between water and the SC. RESULTS: The SC thickness was similar in both groups; however, the TEWL was higher in patients with AD compared with that of the control group (mean+/-SD 8.4+/-4.3 and 6.3+/-2.0 g m-2 h-1, respectively). There was a correlation between SC thickness and TEWL in control subjects but no correlation was found in patients with AD. The diffusivity of SLS through uninvolved AD skin was higher compared with normal skin (mean+/-SD 12.7+/-5.8x10(-9) and 6.2+/-3.0x10(-9) cm-2 h-1, respectively), while the partition coefficient between SC and water was lower (mean+/-SD 137+/-64 and 196+/-107, respectively). CONCLUSIONS: The results show a different penetration profile of SLS into the SC of patients with AD compared with control subjects. This indicates that even noninvolved skin in patients with AD has altered barrier characteristics, emphasizing the importance of skin protection and prevention of skin contact with chemicals. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/16792760/Percutaneous_penetration_of_sodium_lauryl_sulphate_is_increased_in_uninvolved_skin_of_patients_with_atopic_dermatitis_compared_with_control_subjects_ L2 - https://doi.org/10.1111/j.1365-2133.2006.07319.x DB - PRIME DP - Unbound Medicine ER -