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Motor alterations associated with exposure to manganese in the environment in Mexico.
Sci Total Environ. 2006 Sep 15; 368(2-3):542-56.ST

Abstract

Overexposure to manganese (Mn) causes neurotoxicity (a Parkinson-like syndrome) or psychiatric damage ("manganese madness"). Several studies have shown alterations to motor and neural behavior associated with exposure to Mn in the workplace. However, there are few studies on the effects of environmental exposure of whole populations. We studied the risk of motor alterations in people living in a mining district in Mexico. We studied 288 individual people (168 women and 120 men) from eight communities at various distances from manganese extraction or processing facilities in the district of Molango. We measured manganese concentrations in airborne particles, water, soil and crops and evaluated the possible routes of Mn exposure. We also took samples of people's blood and determined their concentrations of Mn and lead (Pb). We used "Esquema de Diagnóstico Neuropsicológico" Ardila and Ostrosky-Solís's neuropsychological battery to evaluate motor functions. Concentrations of Mn in drinking water and maize grain were less than detection limits at most sampling sites. Manganese extractable by DTPA in soils ranged between 6 and 280 mg kg(-1) and means were largest close to Mn extraction or processing facilities. Air Mn concentration ranged between 0.003 and 5.86 microg/m(3); the mean value was 0.42 microg/m(3) and median was 0.10 microg/m(3), the average value (geometric mean) resulted to be 0.13 microg/m(3). Mean blood manganese concentration was 10.16 microg/l, and geometric mean 9.44 microg/l, ranged between 5.0 and 31.0 mcrog/l. We found no association between concentrations of Mn in blood and motor tests. There was a statistically significant association between Mn concentrations in air and motor tests that assessed the coordination of two movements (OR 3.69; 95% CI 0.9, 15.13) and position changes in hand movements (OR 3.09; CI 95% 1.07, 8.92). An association with tests evaluating conflictive reactions (task that explores verbal regulations of movements) was also found (OR 2.30; CI 95% 1.00, 5.28). It seems from our results that people living close to the manganese mines and processing plants suffer from an incipient motor deficit, as a result of their inhaling manganese-rich dust.

Authors+Show Affiliations

Instituto Nacional de Neurología and Neurocirugía Manuel Velasco Suárez, Mexico.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16793118

Citation

Rodríguez-Agudelo, Yaneth, et al. "Motor Alterations Associated With Exposure to Manganese in the Environment in Mexico." The Science of the Total Environment, vol. 368, no. 2-3, 2006, pp. 542-56.
Rodríguez-Agudelo Y, Riojas-Rodríguez H, Ríos C, et al. Motor alterations associated with exposure to manganese in the environment in Mexico. Sci Total Environ. 2006;368(2-3):542-56.
Rodríguez-Agudelo, Y., Riojas-Rodríguez, H., Ríos, C., Rosas, I., Sabido Pedraza, E., Miranda, J., Siebe, C., Texcalac, J. L., & Santos-Burgoa, C. (2006). Motor alterations associated with exposure to manganese in the environment in Mexico. The Science of the Total Environment, 368(2-3), 542-56.
Rodríguez-Agudelo Y, et al. Motor Alterations Associated With Exposure to Manganese in the Environment in Mexico. Sci Total Environ. 2006 Sep 15;368(2-3):542-56. PubMed PMID: 16793118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Motor alterations associated with exposure to manganese in the environment in Mexico. AU - Rodríguez-Agudelo,Yaneth, AU - Riojas-Rodríguez,Horacio, AU - Ríos,Camilo, AU - Rosas,Irma, AU - Sabido Pedraza,Eva, AU - Miranda,Javier, AU - Siebe,Christina, AU - Texcalac,José Luis, AU - Santos-Burgoa,Carlos, Y1 - 2006/06/21/ PY - 2005/10/21/received PY - 2006/01/20/revised PY - 2006/03/16/accepted PY - 2006/6/24/pubmed PY - 2006/11/7/medline PY - 2006/6/24/entrez SP - 542 EP - 56 JF - The Science of the total environment JO - Sci Total Environ VL - 368 IS - 2-3 N2 - Overexposure to manganese (Mn) causes neurotoxicity (a Parkinson-like syndrome) or psychiatric damage ("manganese madness"). Several studies have shown alterations to motor and neural behavior associated with exposure to Mn in the workplace. However, there are few studies on the effects of environmental exposure of whole populations. We studied the risk of motor alterations in people living in a mining district in Mexico. We studied 288 individual people (168 women and 120 men) from eight communities at various distances from manganese extraction or processing facilities in the district of Molango. We measured manganese concentrations in airborne particles, water, soil and crops and evaluated the possible routes of Mn exposure. We also took samples of people's blood and determined their concentrations of Mn and lead (Pb). We used "Esquema de Diagnóstico Neuropsicológico" Ardila and Ostrosky-Solís's neuropsychological battery to evaluate motor functions. Concentrations of Mn in drinking water and maize grain were less than detection limits at most sampling sites. Manganese extractable by DTPA in soils ranged between 6 and 280 mg kg(-1) and means were largest close to Mn extraction or processing facilities. Air Mn concentration ranged between 0.003 and 5.86 microg/m(3); the mean value was 0.42 microg/m(3) and median was 0.10 microg/m(3), the average value (geometric mean) resulted to be 0.13 microg/m(3). Mean blood manganese concentration was 10.16 microg/l, and geometric mean 9.44 microg/l, ranged between 5.0 and 31.0 mcrog/l. We found no association between concentrations of Mn in blood and motor tests. There was a statistically significant association between Mn concentrations in air and motor tests that assessed the coordination of two movements (OR 3.69; 95% CI 0.9, 15.13) and position changes in hand movements (OR 3.09; CI 95% 1.07, 8.92). An association with tests evaluating conflictive reactions (task that explores verbal regulations of movements) was also found (OR 2.30; CI 95% 1.00, 5.28). It seems from our results that people living close to the manganese mines and processing plants suffer from an incipient motor deficit, as a result of their inhaling manganese-rich dust. SN - 0048-9697 UR - https://www.unboundmedicine.com/medline/citation/16793118/Motor_alterations_associated_with_exposure_to_manganese_in_the_environment_in_Mexico_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(06)00255-5 DB - PRIME DP - Unbound Medicine ER -