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Multifocal visual evoked responses to dichoptic stimulation using virtual reality goggles: Multifocal VER to dichoptic stimulation.
Doc Ophthalmol. 2006 May; 112(3):189-99.DO

Abstract

Multifocal visual evoked potentials (mfVEPs) have demonstrated good diagnostic capabilities in glaucoma and optic neuritis. This study aimed at evaluating the possibility of simultaneously recording mfVEP for both eyes with dichoptic stimulation using virtual reality goggles and also to determine the stimulus characteristics that yield maximum amplitude. ten healthy volunteers were recruited and temporally sparse pattern pulse stimuli were presented dichoptically using virtual reality goggles. Experiment 1 involved recording responses to dichoptically presented checkerboard stimuli and also confirming true topographic representation by switching off specific segments. Experiment 2 involved monocular stimulation and comparison of amplitude with Experiment 1. In Experiment 3, orthogonally oriented gratings were dichoptically presented. Experiment 4 involved dichoptic presentation of checkerboard stimuli at different levels of sparseness (5.0 times/s, 2.5 times/s, 1.66 times/s and 1.25 times/s), where stimulation of corresponding segments of two eyes were separated by 16.7, 66.7,116.7 & 166.7 ms respectively. Experiment 1 demonstrated good traces in all regions and confirmed topographic representation. However, there was suppression of amplitude of responses to dichoptic stimulation by 17.9+/-5.4% compared to monocular stimulation. Experiment 3 demonstrated similar suppression between orthogonal and checkerboard stimuli (p = 0.08). Experiment 4 demonstrated maximum amplitude and least suppression (4.8%) with stimulation at 1.25 times/s with 166.7 ms separation between eyes. It is possible to record mfVEP for both eyes during dichoptic stimulation using virtual reality goggles, which present binocular simultaneous patterns driven by independent sequences. Interocular suppression can be almost eliminated by using a temporally sparse stimulus of 1.25 times/s with a separation of 166.7 ms between stimulation of corresponding segments of the two eyes.

Authors+Show Affiliations

Save Sight Institute, Sydney Eye Hospital, University of Sydney, Marquire Street, PO Box 4337, Sydney, 2001, NSW, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16794775

Citation

Arvind, Hemamalini, et al. "Multifocal Visual Evoked Responses to Dichoptic Stimulation Using Virtual Reality Goggles: Multifocal VER to Dichoptic Stimulation." Documenta Ophthalmologica. Advances in Ophthalmology, vol. 112, no. 3, 2006, pp. 189-99.
Arvind H, Klistorner A, Graham SL, et al. Multifocal visual evoked responses to dichoptic stimulation using virtual reality goggles: Multifocal VER to dichoptic stimulation. Doc Ophthalmol. 2006;112(3):189-99.
Arvind, H., Klistorner, A., Graham, S. L., & Grigg, J. R. (2006). Multifocal visual evoked responses to dichoptic stimulation using virtual reality goggles: Multifocal VER to dichoptic stimulation. Documenta Ophthalmologica. Advances in Ophthalmology, 112(3), 189-99.
Arvind H, et al. Multifocal Visual Evoked Responses to Dichoptic Stimulation Using Virtual Reality Goggles: Multifocal VER to Dichoptic Stimulation. Doc Ophthalmol. 2006;112(3):189-99. PubMed PMID: 16794775.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multifocal visual evoked responses to dichoptic stimulation using virtual reality goggles: Multifocal VER to dichoptic stimulation. AU - Arvind,Hemamalini, AU - Klistorner,Alexander, AU - Graham,Stuart L, AU - Grigg,John R, Y1 - 2006/06/22/ PY - 2006/01/28/accepted PY - 2006/6/24/pubmed PY - 2007/1/19/medline PY - 2006/6/24/entrez SP - 189 EP - 99 JF - Documenta ophthalmologica. Advances in ophthalmology JO - Doc Ophthalmol VL - 112 IS - 3 N2 - Multifocal visual evoked potentials (mfVEPs) have demonstrated good diagnostic capabilities in glaucoma and optic neuritis. This study aimed at evaluating the possibility of simultaneously recording mfVEP for both eyes with dichoptic stimulation using virtual reality goggles and also to determine the stimulus characteristics that yield maximum amplitude. ten healthy volunteers were recruited and temporally sparse pattern pulse stimuli were presented dichoptically using virtual reality goggles. Experiment 1 involved recording responses to dichoptically presented checkerboard stimuli and also confirming true topographic representation by switching off specific segments. Experiment 2 involved monocular stimulation and comparison of amplitude with Experiment 1. In Experiment 3, orthogonally oriented gratings were dichoptically presented. Experiment 4 involved dichoptic presentation of checkerboard stimuli at different levels of sparseness (5.0 times/s, 2.5 times/s, 1.66 times/s and 1.25 times/s), where stimulation of corresponding segments of two eyes were separated by 16.7, 66.7,116.7 & 166.7 ms respectively. Experiment 1 demonstrated good traces in all regions and confirmed topographic representation. However, there was suppression of amplitude of responses to dichoptic stimulation by 17.9+/-5.4% compared to monocular stimulation. Experiment 3 demonstrated similar suppression between orthogonal and checkerboard stimuli (p = 0.08). Experiment 4 demonstrated maximum amplitude and least suppression (4.8%) with stimulation at 1.25 times/s with 166.7 ms separation between eyes. It is possible to record mfVEP for both eyes during dichoptic stimulation using virtual reality goggles, which present binocular simultaneous patterns driven by independent sequences. Interocular suppression can be almost eliminated by using a temporally sparse stimulus of 1.25 times/s with a separation of 166.7 ms between stimulation of corresponding segments of the two eyes. SN - 0012-4486 UR - https://www.unboundmedicine.com/medline/citation/16794775/Multifocal_visual_evoked_responses_to_dichoptic_stimulation_using_virtual_reality_goggles:_Multifocal_VER_to_dichoptic_stimulation_ L2 - https://doi.org/10.1007/s10633-006-0005-y DB - PRIME DP - Unbound Medicine ER -