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Optimization of bilayer floating tablet containing metoprolol tartrate as a model drug for gastric retention.
AAPS PharmSciTech. 2006 Apr 07; 7(2):E34.AP

Abstract

The purpose of the present study was to develop an optimized gastric floating drug delivery system (GFDDS) containing metoprolol tartrate (MT) as a model drug by the optimization technique. A 2(3) factorial design was employed in formulating the GFDDS with total polymer content-to-drug ratio (X1), polymer-to-polymer ratio (X2), and different viscosity grades of hydroxypropyl methyl cellulose (HPMC) (X3) as independent variables. Four dependent variables were considered: percentage of MT release at 8 hours, T50%, diffusion coefficient, and floating time. The main effect and interaction terms were quantitatively evaluated using a mathematical model. The results indicate that X1 and X2 significantly affected the floating time and release properties, but the effect of different viscosity grades of HPMC (K4M and K10M) was nonsignificant. Regression analysis and numerical optimization were performed to identify the best formulation. Fickian release transport was confirmed as the release mechanism from the optimized formulation. The predicted values agreed well with the experimental values, and the results demonstrate the feasibility of the model in the development of GFDDS.

Authors+Show Affiliations

Department of Pharmaceutics, Krupanidhi College of Pharmacy, Bangalore-34, India. narendragcp@rediffmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16796352

Citation

Narendra, C, et al. "Optimization of Bilayer Floating Tablet Containing Metoprolol Tartrate as a Model Drug for Gastric Retention." AAPS PharmSciTech, vol. 7, no. 2, 2006, pp. E34.
Narendra C, Srinath MS, Babu G. Optimization of bilayer floating tablet containing metoprolol tartrate as a model drug for gastric retention. AAPS PharmSciTech. 2006;7(2):E34.
Narendra, C., Srinath, M. S., & Babu, G. (2006). Optimization of bilayer floating tablet containing metoprolol tartrate as a model drug for gastric retention. AAPS PharmSciTech, 7(2), E34.
Narendra C, Srinath MS, Babu G. Optimization of Bilayer Floating Tablet Containing Metoprolol Tartrate as a Model Drug for Gastric Retention. AAPS PharmSciTech. 2006 Apr 7;7(2):E34. PubMed PMID: 16796352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimization of bilayer floating tablet containing metoprolol tartrate as a model drug for gastric retention. AU - Narendra,C, AU - Srinath,M S, AU - Babu,Ganesh, Y1 - 2006/04/07/ PY - 2006/6/27/pubmed PY - 2006/7/21/medline PY - 2006/6/27/entrez SP - E34 EP - E34 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 7 IS - 2 N2 - The purpose of the present study was to develop an optimized gastric floating drug delivery system (GFDDS) containing metoprolol tartrate (MT) as a model drug by the optimization technique. A 2(3) factorial design was employed in formulating the GFDDS with total polymer content-to-drug ratio (X1), polymer-to-polymer ratio (X2), and different viscosity grades of hydroxypropyl methyl cellulose (HPMC) (X3) as independent variables. Four dependent variables were considered: percentage of MT release at 8 hours, T50%, diffusion coefficient, and floating time. The main effect and interaction terms were quantitatively evaluated using a mathematical model. The results indicate that X1 and X2 significantly affected the floating time and release properties, but the effect of different viscosity grades of HPMC (K4M and K10M) was nonsignificant. Regression analysis and numerical optimization were performed to identify the best formulation. Fickian release transport was confirmed as the release mechanism from the optimized formulation. The predicted values agreed well with the experimental values, and the results demonstrate the feasibility of the model in the development of GFDDS. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/16796352/Optimization_of_bilayer_floating_tablet_containing_metoprolol_tartrate_as_a_model_drug_for_gastric_retention_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:16796352 DB - PRIME DP - Unbound Medicine ER -