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Hemodialysis-related pruritus and associated cutaneous manifestations.

Abstract

BACKGROUND

Uremic pruritus is one of the most common disabling problems in patients with chronic renal failure. Few studies have evaluated itching and cutaneous manifestations in hemodialysis-dependent patients.

OBJECTIVES

The aim of this prospective study was to identify the prevalence of pruritus and cutaneous changes affecting patients undergoing hemodialysis.

METHODS

The degree of itching in 70 patients treated at the Haemek Medical Center Hemodialysis Unit, in northern Israel, was scored according to presence and severity. We examined the relationship between the quality of dialysis and the frequency of pruritus, and identified concurrent cutaneous disorders.

RESULTS

Pruritus was a common problem in the study cohort and affected 74.3% of hemodialysis patients at some point. The main characteristics of pruritus were a general pattern in 65.7% and mild intensity in 78.3% of observed patients. Duration of hemodialysis varied between 3 months and 13 years. There was no correlation between occurrence of pruritus and demographic or medical parameters (sex, type of kidney disease, regular medications or duration of hemodialysis) of the patients. Higher dialysis efficacy, as expressed by dialyser clearance, volume distribution of area, dialysis duration (Kt/v), may reduce the prevalence of pruritus (P < 0.02). None of the blood and chemical values considered (hemoglobin, creatinine, urea, phosphorus, calcium, albumin, parathormone and alkaline phosphatase) revealed any statistically relevant differences between pruritus groups. The appearance of foot ulcers was different between diabetic and nondiabetic individuals undergoing hemodialysis (P < 0.001).

CONCLUSIONS

Pruritus is still a common problem in hemodialysis-dependent patients. The prevalence of xerosis and excoriations was high in patients undergoing replacement therapy. Efficient replacement hemodialysis may provide a clinical benefit.

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  • Authors+Show Affiliations

    ,

    Department of Dermatology and the Nephrology Unit, Ha'emek Medical Center, Afula, Israel. pavela4@hotmail.com

    ,

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Female
    Humans
    Israel
    Kidney Failure, Chronic
    Male
    Middle Aged
    Patient Selection
    Prevalence
    Pruritus
    Renal Dialysis
    Skin Diseases
    Surveys and Questionnaires
    Uremia

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16796623

    Citation

    Dyachenko, Pavel, et al. "Hemodialysis-related Pruritus and Associated Cutaneous Manifestations." International Journal of Dermatology, vol. 45, no. 6, 2006, pp. 664-7.
    Dyachenko P, Shustak A, Rozenman D. Hemodialysis-related pruritus and associated cutaneous manifestations. Int J Dermatol. 2006;45(6):664-7.
    Dyachenko, P., Shustak, A., & Rozenman, D. (2006). Hemodialysis-related pruritus and associated cutaneous manifestations. International Journal of Dermatology, 45(6), pp. 664-7.
    Dyachenko P, Shustak A, Rozenman D. Hemodialysis-related Pruritus and Associated Cutaneous Manifestations. Int J Dermatol. 2006;45(6):664-7. PubMed PMID: 16796623.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hemodialysis-related pruritus and associated cutaneous manifestations. AU - Dyachenko,Pavel, AU - Shustak,Arshalom, AU - Rozenman,Dganit, PY - 2006/6/27/pubmed PY - 2006/11/15/medline PY - 2006/6/27/entrez SP - 664 EP - 7 JF - International journal of dermatology JO - Int. J. Dermatol. VL - 45 IS - 6 N2 - BACKGROUND: Uremic pruritus is one of the most common disabling problems in patients with chronic renal failure. Few studies have evaluated itching and cutaneous manifestations in hemodialysis-dependent patients. OBJECTIVES: The aim of this prospective study was to identify the prevalence of pruritus and cutaneous changes affecting patients undergoing hemodialysis. METHODS: The degree of itching in 70 patients treated at the Haemek Medical Center Hemodialysis Unit, in northern Israel, was scored according to presence and severity. We examined the relationship between the quality of dialysis and the frequency of pruritus, and identified concurrent cutaneous disorders. RESULTS: Pruritus was a common problem in the study cohort and affected 74.3% of hemodialysis patients at some point. The main characteristics of pruritus were a general pattern in 65.7% and mild intensity in 78.3% of observed patients. Duration of hemodialysis varied between 3 months and 13 years. There was no correlation between occurrence of pruritus and demographic or medical parameters (sex, type of kidney disease, regular medications or duration of hemodialysis) of the patients. Higher dialysis efficacy, as expressed by dialyser clearance, volume distribution of area, dialysis duration (Kt/v), may reduce the prevalence of pruritus (P < 0.02). None of the blood and chemical values considered (hemoglobin, creatinine, urea, phosphorus, calcium, albumin, parathormone and alkaline phosphatase) revealed any statistically relevant differences between pruritus groups. The appearance of foot ulcers was different between diabetic and nondiabetic individuals undergoing hemodialysis (P < 0.001). CONCLUSIONS: Pruritus is still a common problem in hemodialysis-dependent patients. The prevalence of xerosis and excoriations was high in patients undergoing replacement therapy. Efficient replacement hemodialysis may provide a clinical benefit. SN - 0011-9059 UR - https://www.unboundmedicine.com/medline/citation/16796623/Hemodialysis_related_pruritus_and_associated_cutaneous_manifestations_ L2 - https://doi.org/10.1111/j.1365-4632.2005.02592.x DB - PRIME DP - Unbound Medicine ER -