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Optic disc topography and peripapillary retinal nerve fiber layer thickness in nonarteritic ischemic optic neuropathy and open-angle glaucoma.
Ophthalmology. 2006 Aug; 113(8):1340-4.O

Abstract

OBJECTIVE

To evaluate the results of scanning laser tomography and scanning laser polarimetry (SLP) and the correlations with visual field damage (VFD) in eyes with nonarteritic ischemic optic neuropathy (n-AION) compared with eyes with open-angle glaucoma (OAG).

DESIGN

Cross-sectional study.

PARTICIPANTS

Thirty-three eyes of 33 patients with n-AION and 33 eyes with OAG whose age and VFD evaluated with the Humphrey field analyzer were matched to those of the n-AION eyes.

MAIN OUTCOME MEASURES

The parameters of optic disc topography obtained with the Heidelberg Retina Tomograph II (HRT II) and retinal nerve fiber layer (RNFL) thickness with GDx with variable corneal compensation and the correlation to VFD.

RESULTS

The cup area, cup-to-disc area ratio, and mean cup depth were significantly smaller, and the cup shape measure more negative, in the n-AION eyes than in the OAG eyes (P<0.001), whereas rim area was significantly greater (P<0.001). Multivariate analyses showed that none of disc area, rim area, and mean cup depth in the n-AION eyes and only rim area (P = 0.029) in the OAG eyes was significantly associated with mean deviation (MD). Ellipse average of RNFL thickness significantly correlated with MD in the n-AION eyes (P = 0.045) and in the OAG eyes (P = 0.022).

CONCLUSIONS

Disc topography of eyes with n-AION was quantitatively characterized by small and shallow cupping and a relatively large rim area compared to eyes with OAG matched for age and VFD. In eyes with n-AION, significant correlation with VFD was found only for the RNFL thickness evaluated with SLP but not for the HRT II parameters.

Authors+Show Affiliations

Department of Ophthalmology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

16797709

Citation

Saito, Hitomi, et al. "Optic Disc Topography and Peripapillary Retinal Nerve Fiber Layer Thickness in Nonarteritic Ischemic Optic Neuropathy and Open-angle Glaucoma." Ophthalmology, vol. 113, no. 8, 2006, pp. 1340-4.
Saito H, Tomidokoro A, Sugimoto E, et al. Optic disc topography and peripapillary retinal nerve fiber layer thickness in nonarteritic ischemic optic neuropathy and open-angle glaucoma. Ophthalmology. 2006;113(8):1340-4.
Saito, H., Tomidokoro, A., Sugimoto, E., Aihara, M., Tomita, G., Fujie, K., Wakakura, M., & Araie, M. (2006). Optic disc topography and peripapillary retinal nerve fiber layer thickness in nonarteritic ischemic optic neuropathy and open-angle glaucoma. Ophthalmology, 113(8), 1340-4.
Saito H, et al. Optic Disc Topography and Peripapillary Retinal Nerve Fiber Layer Thickness in Nonarteritic Ischemic Optic Neuropathy and Open-angle Glaucoma. Ophthalmology. 2006;113(8):1340-4. PubMed PMID: 16797709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optic disc topography and peripapillary retinal nerve fiber layer thickness in nonarteritic ischemic optic neuropathy and open-angle glaucoma. AU - Saito,Hitomi, AU - Tomidokoro,Atsuo, AU - Sugimoto,Eiichiro, AU - Aihara,Makoto, AU - Tomita,Goji, AU - Fujie,Kazutaka, AU - Wakakura,Masato, AU - Araie,Makoto, Y1 - 2006/06/22/ PY - 2005/08/16/received PY - 2006/01/13/revised PY - 2006/01/26/accepted PY - 2006/6/27/pubmed PY - 2006/8/17/medline PY - 2006/6/27/entrez SP - 1340 EP - 4 JF - Ophthalmology JO - Ophthalmology VL - 113 IS - 8 N2 - OBJECTIVE: To evaluate the results of scanning laser tomography and scanning laser polarimetry (SLP) and the correlations with visual field damage (VFD) in eyes with nonarteritic ischemic optic neuropathy (n-AION) compared with eyes with open-angle glaucoma (OAG). DESIGN: Cross-sectional study. PARTICIPANTS: Thirty-three eyes of 33 patients with n-AION and 33 eyes with OAG whose age and VFD evaluated with the Humphrey field analyzer were matched to those of the n-AION eyes. MAIN OUTCOME MEASURES: The parameters of optic disc topography obtained with the Heidelberg Retina Tomograph II (HRT II) and retinal nerve fiber layer (RNFL) thickness with GDx with variable corneal compensation and the correlation to VFD. RESULTS: The cup area, cup-to-disc area ratio, and mean cup depth were significantly smaller, and the cup shape measure more negative, in the n-AION eyes than in the OAG eyes (P<0.001), whereas rim area was significantly greater (P<0.001). Multivariate analyses showed that none of disc area, rim area, and mean cup depth in the n-AION eyes and only rim area (P = 0.029) in the OAG eyes was significantly associated with mean deviation (MD). Ellipse average of RNFL thickness significantly correlated with MD in the n-AION eyes (P = 0.045) and in the OAG eyes (P = 0.022). CONCLUSIONS: Disc topography of eyes with n-AION was quantitatively characterized by small and shallow cupping and a relatively large rim area compared to eyes with OAG matched for age and VFD. In eyes with n-AION, significant correlation with VFD was found only for the RNFL thickness evaluated with SLP but not for the HRT II parameters. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/16797709/Optic_disc_topography_and_peripapillary_retinal_nerve_fiber_layer_thickness_in_nonarteritic_ischemic_optic_neuropathy_and_open_angle_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)00540-9 DB - PRIME DP - Unbound Medicine ER -