Fernandes, Christian, et al. "Dissolution Test for Lamivudine Tablets: Optimization and Statistical Analysis." Journal of Pharmaceutical and Biomedical Analysis, vol. 42, no. 5, 2006, pp. 601-6.
Fernandes C, Junqueira RG, Campos LM, et al. Dissolution test for lamivudine tablets: optimization and statistical analysis. J Pharm Biomed Anal. 2006;42(5):601-6.
Fernandes, C., Junqueira, R. G., Campos, L. M., & Pianetti, G. A. (2006). Dissolution test for lamivudine tablets: optimization and statistical analysis. Journal of Pharmaceutical and Biomedical Analysis, 42(5), 601-6.
Fernandes C, et al. Dissolution Test for Lamivudine Tablets: Optimization and Statistical Analysis. J Pharm Biomed Anal. 2006 Nov 16;42(5):601-6. PubMed PMID: 16797911.
TY - JOUR
T1 - Dissolution test for lamivudine tablets: optimization and statistical analysis.
AU - Fernandes,Christian,
AU - Junqueira,Roberto Gonçalves,
AU - Campos,Ligia Maria Moreira,
AU - Pianetti,Gerson Antônio,
Y1 - 2006/06/22/
PY - 2006/03/03/received
PY - 2006/05/10/revised
PY - 2006/05/12/accepted
PY - 2006/6/27/pubmed
PY - 2007/2/8/medline
PY - 2006/6/27/entrez
SP - 601
EP - 6
JF - Journal of pharmaceutical and biomedical analysis
JO - J Pharm Biomed Anal
VL - 42
IS - 5
N2 - A comparison of different methods for dissolution test used by five different manufacturer laboratories of lamivudine tablets is made, evaluated, and discussed. Dissolution medium (water and hydrochloric acid pH 1.2), apparatus (paddles and baskets) and time (30 and 60 min) were analyzed. The determination was accomplished by spectrophotometry at 270 nm. Analysis of variance (ANOVA) factorial design 5 x 2 x 2 x 2 with six repetitions, with post hoc multiple comparisons between means conducted by Duncan test at 0.05 significance level was used. After the comparative analysis of the results, optimal dissolution conditions were determined as follows: water as dissolution medium, paddles at the stirring speed of 50 rpm as apparatus and time of 30 min. The method was applied to the dissolution test of samples from eleven batches of tablets, produced by five different laboratories.
SN - 0731-7085
UR - https://www.unboundmedicine.com/medline/citation/16797911/Dissolution_test_for_lamivudine_tablets:_optimization_and_statistical_analysis_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(06)00386-4
DB - PRIME
DP - Unbound Medicine