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Dissolution test for lamivudine tablets: optimization and statistical analysis.
J Pharm Biomed Anal. 2006 Nov 16; 42(5):601-6.JP

Abstract

A comparison of different methods for dissolution test used by five different manufacturer laboratories of lamivudine tablets is made, evaluated, and discussed. Dissolution medium (water and hydrochloric acid pH 1.2), apparatus (paddles and baskets) and time (30 and 60 min) were analyzed. The determination was accomplished by spectrophotometry at 270 nm. Analysis of variance (ANOVA) factorial design 5 x 2 x 2 x 2 with six repetitions, with post hoc multiple comparisons between means conducted by Duncan test at 0.05 significance level was used. After the comparative analysis of the results, optimal dissolution conditions were determined as follows: water as dissolution medium, paddles at the stirring speed of 50 rpm as apparatus and time of 30 min. The method was applied to the dissolution test of samples from eleven batches of tablets, produced by five different laboratories.

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Authors+Show Affiliations

Fernandes C
Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627 Pampulha, CEP 31270-901, Belo Horizonte, MG, Brazil. cfernandes@iqsc.usp.br
Junqueira RG
No affiliation info available
Campos LM
No affiliation info available
Pianetti GA
No affiliation info available

MeSH

Analysis of VarianceAnti-HIV AgentsHydrochloric AcidHydrogen-Ion ConcentrationLamivudineQuality ControlSolubilityTabletsWater

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16797911

Citation

Fernandes, Christian, et al. "Dissolution Test for Lamivudine Tablets: Optimization and Statistical Analysis." Journal of Pharmaceutical and Biomedical Analysis, vol. 42, no. 5, 2006, pp. 601-6.
Fernandes C, Junqueira RG, Campos LM, et al. Dissolution test for lamivudine tablets: optimization and statistical analysis. J Pharm Biomed Anal. 2006;42(5):601-6.
Fernandes, C., Junqueira, R. G., Campos, L. M., & Pianetti, G. A. (2006). Dissolution test for lamivudine tablets: optimization and statistical analysis. Journal of Pharmaceutical and Biomedical Analysis, 42(5), 601-6.
Fernandes C, et al. Dissolution Test for Lamivudine Tablets: Optimization and Statistical Analysis. J Pharm Biomed Anal. 2006 Nov 16;42(5):601-6. PubMed PMID: 16797911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dissolution test for lamivudine tablets: optimization and statistical analysis. AU - Fernandes,Christian, AU - Junqueira,Roberto Gonçalves, AU - Campos,Ligia Maria Moreira, AU - Pianetti,Gerson Antônio, Y1 - 2006/06/22/ PY - 2006/03/03/received PY - 2006/05/10/revised PY - 2006/05/12/accepted PY - 2006/6/27/pubmed PY - 2007/2/8/medline PY - 2006/6/27/entrez SP - 601 EP - 6 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 42 IS - 5 N2 - A comparison of different methods for dissolution test used by five different manufacturer laboratories of lamivudine tablets is made, evaluated, and discussed. Dissolution medium (water and hydrochloric acid pH 1.2), apparatus (paddles and baskets) and time (30 and 60 min) were analyzed. The determination was accomplished by spectrophotometry at 270 nm. Analysis of variance (ANOVA) factorial design 5 x 2 x 2 x 2 with six repetitions, with post hoc multiple comparisons between means conducted by Duncan test at 0.05 significance level was used. After the comparative analysis of the results, optimal dissolution conditions were determined as follows: water as dissolution medium, paddles at the stirring speed of 50 rpm as apparatus and time of 30 min. The method was applied to the dissolution test of samples from eleven batches of tablets, produced by five different laboratories. SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/16797911/Dissolution_test_for_lamivudine_tablets:_optimization_and_statistical_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(06)00386-4 DB - PRIME DP - Unbound Medicine ER -