Tags

Type your tag names separated by a space and hit enter

Cell-cell interaction in the transcellular biosynthesis of novel omega-3-derived lipid mediators.
Methods Mol Biol. 2006; 341:227-50.MM

Abstract

Omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosa-hexaenoic acid (DHA) display beneficial actions in human diseases. The molecular basis for these actions remains of interest. We recently identified novel mediators generated from omega-3 PUFA during cell-cell interactions that displayed potent anti-inflammatory and proresolving actions. Compounds derived from EPA are designated resolvins of the E series (RvE1), and those biosynthesized from DHA are denoted resolvins of the D series (RvD) and docosatriene, such as protectin D1 (PD1), which belongs to the family of protectins. In addition, treatment using aspirin initiates a related epimeric series by triggering endogenous formation of the 17R-RvD series, denoted as aspirin-triggered (AT)-RvDs. These compounds possess potent anti-inflammatory actions in vivo that essentially are equivalent to their counterpart generated without aspirin, namely the 17S-RvDs. In this chapter, we provide an overview and detail protocols of the biosynthesis and bioactions of these newly uncovered pathways and products that include three distinct series: 18R-resolvins of the E series derived from EPA (i.e., RvE1); 17R-resolvins of the D series from DHA (AT-RvD1 through RvD4); and 17S-resolvins of the D series from DHA (RvD1 through RvD4).

Authors+Show Affiliations

Department of Anesthesiology, Perioperative, and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

16799203

Citation

Chiang, Nan, and Charles N. Serhan. "Cell-cell Interaction in the Transcellular Biosynthesis of Novel Omega-3-derived Lipid Mediators." Methods in Molecular Biology (Clifton, N.J.), vol. 341, 2006, pp. 227-50.
Chiang N, Serhan CN. Cell-cell interaction in the transcellular biosynthesis of novel omega-3-derived lipid mediators. Methods Mol Biol. 2006;341:227-50.
Chiang, N., & Serhan, C. N. (2006). Cell-cell interaction in the transcellular biosynthesis of novel omega-3-derived lipid mediators. Methods in Molecular Biology (Clifton, N.J.), 341, 227-50.
Chiang N, Serhan CN. Cell-cell Interaction in the Transcellular Biosynthesis of Novel Omega-3-derived Lipid Mediators. Methods Mol Biol. 2006;341:227-50. PubMed PMID: 16799203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cell-cell interaction in the transcellular biosynthesis of novel omega-3-derived lipid mediators. AU - Chiang,Nan, AU - Serhan,Charles N, PY - 2006/6/27/pubmed PY - 2006/11/1/medline PY - 2006/6/27/entrez SP - 227 EP - 50 JF - Methods in molecular biology (Clifton, N.J.) JO - Methods Mol Biol VL - 341 N2 - Omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosa-hexaenoic acid (DHA) display beneficial actions in human diseases. The molecular basis for these actions remains of interest. We recently identified novel mediators generated from omega-3 PUFA during cell-cell interactions that displayed potent anti-inflammatory and proresolving actions. Compounds derived from EPA are designated resolvins of the E series (RvE1), and those biosynthesized from DHA are denoted resolvins of the D series (RvD) and docosatriene, such as protectin D1 (PD1), which belongs to the family of protectins. In addition, treatment using aspirin initiates a related epimeric series by triggering endogenous formation of the 17R-RvD series, denoted as aspirin-triggered (AT)-RvDs. These compounds possess potent anti-inflammatory actions in vivo that essentially are equivalent to their counterpart generated without aspirin, namely the 17S-RvDs. In this chapter, we provide an overview and detail protocols of the biosynthesis and bioactions of these newly uncovered pathways and products that include three distinct series: 18R-resolvins of the E series derived from EPA (i.e., RvE1); 17R-resolvins of the D series from DHA (AT-RvD1 through RvD4); and 17S-resolvins of the D series from DHA (RvD1 through RvD4). SN - 1064-3745 UR - https://www.unboundmedicine.com/medline/citation/16799203/Cell_cell_interaction_in_the_transcellular_biosynthesis_of_novel_omega_3_derived_lipid_mediators_ L2 - https://dx.doi.org/10.1385/1-59745-113-4:227 DB - PRIME DP - Unbound Medicine ER -