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Association of Chlamydia pneumoniae infection and carotid intima-media wall thickness in Japanese Americans.
Circ J 2006; 70(7):815-9CJ

Abstract

BACKGROUND

Chlamydia pneumoniae (Cp) infection has been proposed as a risk factor for coronary artery disease (CAD), but it remains unclear whether Cp plays a role in the progression of early stage carotid atherosclerosis.

METHODS AND RESULTS

The associations among Cp IgG/IgA antibodies, inflammation markers such as C-reactive protein (CRP) and interleukin (IL)-6, and the maximal progression of carotid intima-media wall thickness (max IMT) were evaluated using ultrasonography in 259 Japanese Americans. The presence of Cp IgG or IgA antibodies itself did not show significant correlation with max IMT after adjustment for age and sex. However, in the Cp IgG seropositive group, the subjects with high IL-6 levels showed more pronounced max IMT progression than those with low IL-6 levels after adjustment of the other CAD risk factors. Moreover, in the Cp IgA seropositive group, the subjects with high CRP or IL-6 levels had significantly higher levels of max IMT compared with those with low CRP or IL-6.

CONCLUSIONS

The results support the hypothesis that a chronic latent Cp infection with inflammation might accelerate the development of early stage atherosclerotic lesions.

Authors+Show Affiliations

Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Programs for Applied Biomedicine, Hiroshima University, Hiroshima, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16799231

Citation

Jitsuiki, Kuniaki, et al. "Association of Chlamydia Pneumoniae Infection and Carotid Intima-media Wall Thickness in Japanese Americans." Circulation Journal : Official Journal of the Japanese Circulation Society, vol. 70, no. 7, 2006, pp. 815-9.
Jitsuiki K, Yamane K, Nakajima M, et al. Association of Chlamydia pneumoniae infection and carotid intima-media wall thickness in Japanese Americans. Circ J. 2006;70(7):815-9.
Jitsuiki, K., Yamane, K., Nakajima, M., Nakanishi, S., Tasaki, N., Watanabe, H., ... Kohno, N. (2006). Association of Chlamydia pneumoniae infection and carotid intima-media wall thickness in Japanese Americans. Circulation Journal : Official Journal of the Japanese Circulation Society, 70(7), pp. 815-9.
Jitsuiki K, et al. Association of Chlamydia Pneumoniae Infection and Carotid Intima-media Wall Thickness in Japanese Americans. Circ J. 2006;70(7):815-9. PubMed PMID: 16799231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of Chlamydia pneumoniae infection and carotid intima-media wall thickness in Japanese Americans. AU - Jitsuiki,Kuniaki, AU - Yamane,Kiminori, AU - Nakajima,Masamitsu, AU - Nakanishi,Shuhei, AU - Tasaki,Naohito, AU - Watanabe,Hiroshi, AU - Kurihara,Hidemi, AU - Kohno,Nobuoki, PY - 2006/6/27/pubmed PY - 2006/8/11/medline PY - 2006/6/27/entrez SP - 815 EP - 9 JF - Circulation journal : official journal of the Japanese Circulation Society JO - Circ. J. VL - 70 IS - 7 N2 - BACKGROUND: Chlamydia pneumoniae (Cp) infection has been proposed as a risk factor for coronary artery disease (CAD), but it remains unclear whether Cp plays a role in the progression of early stage carotid atherosclerosis. METHODS AND RESULTS: The associations among Cp IgG/IgA antibodies, inflammation markers such as C-reactive protein (CRP) and interleukin (IL)-6, and the maximal progression of carotid intima-media wall thickness (max IMT) were evaluated using ultrasonography in 259 Japanese Americans. The presence of Cp IgG or IgA antibodies itself did not show significant correlation with max IMT after adjustment for age and sex. However, in the Cp IgG seropositive group, the subjects with high IL-6 levels showed more pronounced max IMT progression than those with low IL-6 levels after adjustment of the other CAD risk factors. Moreover, in the Cp IgA seropositive group, the subjects with high CRP or IL-6 levels had significantly higher levels of max IMT compared with those with low CRP or IL-6. CONCLUSIONS: The results support the hypothesis that a chronic latent Cp infection with inflammation might accelerate the development of early stage atherosclerotic lesions. SN - 1346-9843 UR - https://www.unboundmedicine.com/medline/citation/16799231/Association_of_Chlamydia_pneumoniae_infection_and_carotid_intima_media_wall_thickness_in_Japanese_Americans_ L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/circj/70.815?from=PubMed DB - PRIME DP - Unbound Medicine ER -