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Effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer.
J Assoc Physicians India. 2006 Mar; 54:183-6.JA

Abstract

AIM

To evaluate the effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer.

METHOD

A total of 55 postoperative patients of breast cancer were given tablet tamoxifen 20mg orally daily for 6 months. Estimation of plasma lipid by standard method was carried out in both pre-menopausal and postmenopausal new patients of early stage breast cancer at 0 day, 3rd month and 6th months of therapy.

RESULTS

Suggested that in pre-menopausal and postmenopausal patient's TC and LDL-c levels were reduced significantly, whereas, TG, VLDL-c and HDL-c were not altered. Comparison of the effects of tamoxifen in pre-menopausal and postmenopausal patients on lipid profile revealed that fall in TC and LDL-c was significantly higher at both 3 and 6 months in postmenopausal patients.

CONCLUSION

The study demonstrates that tamoxifen to favorably alter the markers of cardiovascular risk in both pre-menopausal and postmenopausal patients of breast cancer.

Authors+Show Affiliations

Post Graduate Department of Pharmacology and Therapeutics, Government Medical College, Jammu (J&K) India 180001.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

16800341

Citation

Gupta, Sapna, et al. "Effects of Tamoxifen Therapy On Plasma Lipid Profile in Patients of Breast Cancer." The Journal of the Association of Physicians of India, vol. 54, 2006, pp. 183-6.
Gupta S, Tandon VR, Kapoor B, et al. Effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer. J Assoc Physicians India. 2006;54:183-6.
Gupta, S., Tandon, V. R., Kapoor, B., Gupta, A., Gupta, G. D., & Khajuria, V. (2006). Effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer. The Journal of the Association of Physicians of India, 54, 183-6.
Gupta S, et al. Effects of Tamoxifen Therapy On Plasma Lipid Profile in Patients of Breast Cancer. J Assoc Physicians India. 2006;54:183-6. PubMed PMID: 16800341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer. AU - Gupta,Sapna, AU - Tandon,V R, AU - Kapoor,B, AU - Gupta,A, AU - Gupta,G D, AU - Khajuria,V, PY - 2006/6/28/pubmed PY - 2006/7/28/medline PY - 2006/6/28/entrez SP - 183 EP - 6 JF - The Journal of the Association of Physicians of India JO - J Assoc Physicians India VL - 54 N2 - AIM: To evaluate the effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer. METHOD: A total of 55 postoperative patients of breast cancer were given tablet tamoxifen 20mg orally daily for 6 months. Estimation of plasma lipid by standard method was carried out in both pre-menopausal and postmenopausal new patients of early stage breast cancer at 0 day, 3rd month and 6th months of therapy. RESULTS: Suggested that in pre-menopausal and postmenopausal patient's TC and LDL-c levels were reduced significantly, whereas, TG, VLDL-c and HDL-c were not altered. Comparison of the effects of tamoxifen in pre-menopausal and postmenopausal patients on lipid profile revealed that fall in TC and LDL-c was significantly higher at both 3 and 6 months in postmenopausal patients. CONCLUSION: The study demonstrates that tamoxifen to favorably alter the markers of cardiovascular risk in both pre-menopausal and postmenopausal patients of breast cancer. SN - 0004-5772 UR - https://www.unboundmedicine.com/medline/citation/16800341/Effects_of_tamoxifen_therapy_on_plasma_lipid_profile_in_patients_of_breast_cancer_ L2 - http://www.diseaseinfosearch.org/result/960 DB - PRIME DP - Unbound Medicine ER -