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Plasma lycopene, other carotenoids, and the risk of type 2 diabetes in women.
Am J Epidemiol 2006; 164(6):576-85AJ

Abstract

The authors conducted a nested case-control study from 1992 to 2003 among US women aged 45 years or older and free from cardiovascular disease and cancer to examine the prospective association among plasma lycopene, other carotenoids, and the risk of developing type 2 diabetes. During 10 years of follow-up, 470 cases of incident type 2 diabetes were selected and individually matched on age (+/- 1 year) and follow-up time to 470 nondiabetic controls. Baseline plasma levels of lycopene, alpha-carotene, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin were similar in cases and controls (all p > 0.05). A possible crude inverse association between plasma lycopene and risk of type 2 diabetes was attenuated upon multivariate adjustment. After control for plasma total cholesterol and known diabetes risk factors, the multivariate odds ratios of type 2 diabetes in the highest versus the lowest quartile of plasma carotenoids were 1.13 (95% confidence interval (CI): 0.60, 2.13) for lycopene, 1.27 (95% CI: 0.63, 2.57) for alpha-carotene, 1.10 (95% CI: 0.57, 2.13) for beta-carotene, 0.91 (95% CI: 0.46, 1.81) for beta-cryptoxanthin, and 1.35 (95% CI: 0.68, 2.69) for lutein/zeaxanthin. There was no prospective association between baseline plasma carotenoids and the risk of type 2 diabetes in middle-aged and older women.

Authors+Show Affiliations

Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. luwang@rics.bwh.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16801375

Citation

Wang, Lu, et al. "Plasma Lycopene, Other Carotenoids, and the Risk of Type 2 Diabetes in Women." American Journal of Epidemiology, vol. 164, no. 6, 2006, pp. 576-85.
Wang L, Liu S, Pradhan AD, et al. Plasma lycopene, other carotenoids, and the risk of type 2 diabetes in women. Am J Epidemiol. 2006;164(6):576-85.
Wang, L., Liu, S., Pradhan, A. D., Manson, J. E., Buring, J. E., Gaziano, J. M., & Sesso, H. D. (2006). Plasma lycopene, other carotenoids, and the risk of type 2 diabetes in women. American Journal of Epidemiology, 164(6), pp. 576-85.
Wang L, et al. Plasma Lycopene, Other Carotenoids, and the Risk of Type 2 Diabetes in Women. Am J Epidemiol. 2006 Sep 15;164(6):576-85. PubMed PMID: 16801375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma lycopene, other carotenoids, and the risk of type 2 diabetes in women. AU - Wang,Lu, AU - Liu,Simin, AU - Pradhan,Aruna D, AU - Manson,Joann E, AU - Buring,Julie E, AU - Gaziano,J Michael, AU - Sesso,Howard D, Y1 - 2006/06/26/ PY - 2006/6/28/pubmed PY - 2006/10/14/medline PY - 2006/6/28/entrez SP - 576 EP - 85 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 164 IS - 6 N2 - The authors conducted a nested case-control study from 1992 to 2003 among US women aged 45 years or older and free from cardiovascular disease and cancer to examine the prospective association among plasma lycopene, other carotenoids, and the risk of developing type 2 diabetes. During 10 years of follow-up, 470 cases of incident type 2 diabetes were selected and individually matched on age (+/- 1 year) and follow-up time to 470 nondiabetic controls. Baseline plasma levels of lycopene, alpha-carotene, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin were similar in cases and controls (all p > 0.05). A possible crude inverse association between plasma lycopene and risk of type 2 diabetes was attenuated upon multivariate adjustment. After control for plasma total cholesterol and known diabetes risk factors, the multivariate odds ratios of type 2 diabetes in the highest versus the lowest quartile of plasma carotenoids were 1.13 (95% confidence interval (CI): 0.60, 2.13) for lycopene, 1.27 (95% CI: 0.63, 2.57) for alpha-carotene, 1.10 (95% CI: 0.57, 2.13) for beta-carotene, 0.91 (95% CI: 0.46, 1.81) for beta-cryptoxanthin, and 1.35 (95% CI: 0.68, 2.69) for lutein/zeaxanthin. There was no prospective association between baseline plasma carotenoids and the risk of type 2 diabetes in middle-aged and older women. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/16801375/Plasma_lycopene_other_carotenoids_and_the_risk_of_type_2_diabetes_in_women_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwj240 DB - PRIME DP - Unbound Medicine ER -