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Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study.
Neurology. 2006 Jun 27; 66(12):1941-3.Neur

Abstract

Elevated homocysteine is associated with increased risk of heart disease, stroke, and dementia. Therapy of Parkinson disease (PD) with levodopa elevates homocysteine. The authors conducted a 6-week, multicenter, randomized, double-blind, placebo-controlled trial to test whether folate 1 mg/vitamin B(12) 500 microg or entacapone reduced serum homocysteine in 35 levodopa-treated PD patients. Levodopa initiation caused a small elevation in homocysteine. Vitamin therapy, but not entacapone, resulted in a decrease in homocysteine compared to placebo.

Authors+Show Affiliations

Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada. ron.postuma@muhc.mcgill.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16801668

Citation

Postuma, R B., et al. "Vitamins and Entacapone in Levodopa-induced Hyperhomocysteinemia: a Randomized Controlled Study." Neurology, vol. 66, no. 12, 2006, pp. 1941-3.
Postuma RB, Espay AJ, Zadikoff C, et al. Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study. Neurology. 2006;66(12):1941-3.
Postuma, R. B., Espay, A. J., Zadikoff, C., Suchowersky, O., Martin, W. R., Lafontaine, A. L., Ranawaya, R., Camicioli, R., & Lang, A. E. (2006). Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study. Neurology, 66(12), 1941-3.
Postuma RB, et al. Vitamins and Entacapone in Levodopa-induced Hyperhomocysteinemia: a Randomized Controlled Study. Neurology. 2006 Jun 27;66(12):1941-3. PubMed PMID: 16801668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study. AU - Postuma,R B, AU - Espay,A J, AU - Zadikoff,C, AU - Suchowersky,O, AU - Martin,W R W, AU - Lafontaine,A-L, AU - Ranawaya,R, AU - Camicioli,R, AU - Lang,A E, PY - 2006/6/28/pubmed PY - 2006/7/20/medline PY - 2006/6/28/entrez SP - 1941 EP - 3 JF - Neurology JO - Neurology VL - 66 IS - 12 N2 - Elevated homocysteine is associated with increased risk of heart disease, stroke, and dementia. Therapy of Parkinson disease (PD) with levodopa elevates homocysteine. The authors conducted a 6-week, multicenter, randomized, double-blind, placebo-controlled trial to test whether folate 1 mg/vitamin B(12) 500 microg or entacapone reduced serum homocysteine in 35 levodopa-treated PD patients. Levodopa initiation caused a small elevation in homocysteine. Vitamin therapy, but not entacapone, resulted in a decrease in homocysteine compared to placebo. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/16801668/Vitamins_and_entacapone_in_levodopa_induced_hyperhomocysteinemia:_a_randomized_controlled_study_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=16801668 DB - PRIME DP - Unbound Medicine ER -