Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study.Neurology. 2006 Jun 27; 66(12):1941-3.Neur
Abstract
Elevated homocysteine is associated with increased risk of heart disease, stroke, and dementia. Therapy of Parkinson disease (PD) with levodopa elevates homocysteine. The authors conducted a 6-week, multicenter, randomized, double-blind, placebo-controlled trial to test whether folate 1 mg/vitamin B(12) 500 microg or entacapone reduced serum homocysteine in 35 levodopa-treated PD patients. Levodopa initiation caused a small elevation in homocysteine. Vitamin therapy, but not entacapone, resulted in a decrease in homocysteine compared to placebo.
Links
MeSH
Pub Type(s)
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
16801668
Citation
Postuma, R B., et al. "Vitamins and Entacapone in Levodopa-induced Hyperhomocysteinemia: a Randomized Controlled Study." Neurology, vol. 66, no. 12, 2006, pp. 1941-3.
Postuma RB, Espay AJ, Zadikoff C, et al. Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study. Neurology. 2006;66(12):1941-3.
Postuma, R. B., Espay, A. J., Zadikoff, C., Suchowersky, O., Martin, W. R., Lafontaine, A. L., Ranawaya, R., Camicioli, R., & Lang, A. E. (2006). Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study. Neurology, 66(12), 1941-3.
Postuma RB, et al. Vitamins and Entacapone in Levodopa-induced Hyperhomocysteinemia: a Randomized Controlled Study. Neurology. 2006 Jun 27;66(12):1941-3. PubMed PMID: 16801668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study.
AU - Postuma,R B,
AU - Espay,A J,
AU - Zadikoff,C,
AU - Suchowersky,O,
AU - Martin,W R W,
AU - Lafontaine,A-L,
AU - Ranawaya,R,
AU - Camicioli,R,
AU - Lang,A E,
PY - 2006/6/28/pubmed
PY - 2006/7/20/medline
PY - 2006/6/28/entrez
SP - 1941
EP - 3
JF - Neurology
JO - Neurology
VL - 66
IS - 12
N2 - Elevated homocysteine is associated with increased risk of heart disease, stroke, and dementia. Therapy of Parkinson disease (PD) with levodopa elevates homocysteine. The authors conducted a 6-week, multicenter, randomized, double-blind, placebo-controlled trial to test whether folate 1 mg/vitamin B(12) 500 microg or entacapone reduced serum homocysteine in 35 levodopa-treated PD patients. Levodopa initiation caused a small elevation in homocysteine. Vitamin therapy, but not entacapone, resulted in a decrease in homocysteine compared to placebo.
SN - 1526-632X
UR - https://www.unboundmedicine.com/medline/citation/16801668/Vitamins_and_entacapone_in_levodopa_induced_hyperhomocysteinemia:_a_randomized_controlled_study_
L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=16801668
DB - PRIME
DP - Unbound Medicine
ER -