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Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study.
Neurology. 2006 Jun 27; 66(12):1941-3.Neur

Abstract

Elevated homocysteine is associated with increased risk of heart disease, stroke, and dementia. Therapy of Parkinson disease (PD) with levodopa elevates homocysteine. The authors conducted a 6-week, multicenter, randomized, double-blind, placebo-controlled trial to test whether folate 1 mg/vitamin B(12) 500 microg or entacapone reduced serum homocysteine in 35 levodopa-treated PD patients. Levodopa initiation caused a small elevation in homocysteine. Vitamin therapy, but not entacapone, resulted in a decrease in homocysteine compared to placebo.

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Authors+Show Affiliations

Postuma RB
Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada. ron.postuma@muhc.mcgill.ca
Espay AJ
No affiliation info available
Zadikoff C
No affiliation info available
Suchowersky O
No affiliation info available
Martin WR
No affiliation info available
Lafontaine AL
No affiliation info available
Ranawaya R
No affiliation info available
Camicioli R
No affiliation info available
Lang AE
No affiliation info available

MeSH

AgedAntiparkinson AgentsCanadaCatecholsDouble-Blind MethodDrug CombinationsFemaleFolic AcidHomocysteineHumansHyperhomocysteinemiaLevodopaMaleMiddle AgedNitrilesParkinson DiseasePlacebo EffectTreatment OutcomeUnited StatesVitamin B 12Vitamins

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16801668

Citation

Postuma, R B., et al. "Vitamins and Entacapone in Levodopa-induced Hyperhomocysteinemia: a Randomized Controlled Study." Neurology, vol. 66, no. 12, 2006, pp. 1941-3.
Postuma RB, Espay AJ, Zadikoff C, et al. Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study. Neurology. 2006;66(12):1941-3.
Postuma, R. B., Espay, A. J., Zadikoff, C., Suchowersky, O., Martin, W. R., Lafontaine, A. L., Ranawaya, R., Camicioli, R., & Lang, A. E. (2006). Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study. Neurology, 66(12), 1941-3.
Postuma RB, et al. Vitamins and Entacapone in Levodopa-induced Hyperhomocysteinemia: a Randomized Controlled Study. Neurology. 2006 Jun 27;66(12):1941-3. PubMed PMID: 16801668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study. AU - Postuma,R B, AU - Espay,A J, AU - Zadikoff,C, AU - Suchowersky,O, AU - Martin,W R W, AU - Lafontaine,A-L, AU - Ranawaya,R, AU - Camicioli,R, AU - Lang,A E, PY - 2006/6/28/pubmed PY - 2006/7/20/medline PY - 2006/6/28/entrez SP - 1941 EP - 3 JF - Neurology JO - Neurology VL - 66 IS - 12 N2 - Elevated homocysteine is associated with increased risk of heart disease, stroke, and dementia. Therapy of Parkinson disease (PD) with levodopa elevates homocysteine. The authors conducted a 6-week, multicenter, randomized, double-blind, placebo-controlled trial to test whether folate 1 mg/vitamin B(12) 500 microg or entacapone reduced serum homocysteine in 35 levodopa-treated PD patients. Levodopa initiation caused a small elevation in homocysteine. Vitamin therapy, but not entacapone, resulted in a decrease in homocysteine compared to placebo. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/16801668/Vitamins_and_entacapone_in_levodopa_induced_hyperhomocysteinemia:_a_randomized_controlled_study_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=16801668 DB - PRIME DP - Unbound Medicine ER -