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Regulation of ghrelin is related to estimated insulin sensitivity in obese children.
Int J Obes (Lond) 2006; 30(10):1482-7IJ

Abstract

OBJECTIVE

To investigate whether ghrelin concentrations and their changes during weight loss in obese children are associated with parameters of glucose and insulin metabolism.

DESIGN

Total plasma ghrelin, insulin and glucose were measured during oral glucose tolerance testing before and after diet-induced weight loss over 6 weeks.

SETTING

In-patient rehabilitation program in a pediatric hospital.

PARTICIPANTS

Twenty-three obese children (age 10-16 years) and 11 normal weight controls (age 10-15 years).

OUTCOME MEASURES

Changes in ghrelin concentrations during weight loss and correlation analysis of changes in ghrelin and changes in parameters of glucose and insulin metabolism. After data collection, subgroup analysis of obese patients with high, medium and low estimated insulin sensitivity whole-body insulin sensitivity index (WBISI) was performed.

RESULTS

Weight loss increased the area under the curve (AUC) of ghrelin by 26% (P<0.001). The increase in ghrelin AUC correlated significantly with improved estimated insulin sensitivity (WBISI) (r=0.69, P<0.001). The independent predicting effect of WBISI was confirmed in multivariate analysis. In children with low WBISI, ghrelin reached the level of control values after weight loss. In children with high WBISI, ghrelin increased markedly above control levels.

CONCLUSIONS

Changes in ghrelin are independently associated with changes in glucose and insulin metabolism. The increase in plasma ghrelin above control levels was limited to obese children with high WBISI.

Authors+Show Affiliations

Division of Metabolic Diseases and Nutritional Medicine, Dr von Hauner Children's Hospital, University of Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16801928

Citation

Krohn, K, et al. "Regulation of Ghrelin Is Related to Estimated Insulin Sensitivity in Obese Children." International Journal of Obesity (2005), vol. 30, no. 10, 2006, pp. 1482-7.
Krohn K, Boczan C, Otto B, et al. Regulation of ghrelin is related to estimated insulin sensitivity in obese children. Int J Obes (Lond). 2006;30(10):1482-7.
Krohn, K., Boczan, C., Otto, B., Heldwein, W., Landgraf, R., Bauer, C. P., & Koletzko, B. (2006). Regulation of ghrelin is related to estimated insulin sensitivity in obese children. International Journal of Obesity (2005), 30(10), pp. 1482-7.
Krohn K, et al. Regulation of Ghrelin Is Related to Estimated Insulin Sensitivity in Obese Children. Int J Obes (Lond). 2006;30(10):1482-7. PubMed PMID: 16801928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of ghrelin is related to estimated insulin sensitivity in obese children. AU - Krohn,K, AU - Boczan,C, AU - Otto,B, AU - Heldwein,W, AU - Landgraf,R, AU - Bauer,C P, AU - Koletzko,B, Y1 - 2006/06/27/ PY - 2006/6/28/pubmed PY - 2007/8/8/medline PY - 2006/6/28/entrez SP - 1482 EP - 7 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 30 IS - 10 N2 - OBJECTIVE: To investigate whether ghrelin concentrations and their changes during weight loss in obese children are associated with parameters of glucose and insulin metabolism. DESIGN: Total plasma ghrelin, insulin and glucose were measured during oral glucose tolerance testing before and after diet-induced weight loss over 6 weeks. SETTING: In-patient rehabilitation program in a pediatric hospital. PARTICIPANTS: Twenty-three obese children (age 10-16 years) and 11 normal weight controls (age 10-15 years). OUTCOME MEASURES: Changes in ghrelin concentrations during weight loss and correlation analysis of changes in ghrelin and changes in parameters of glucose and insulin metabolism. After data collection, subgroup analysis of obese patients with high, medium and low estimated insulin sensitivity whole-body insulin sensitivity index (WBISI) was performed. RESULTS: Weight loss increased the area under the curve (AUC) of ghrelin by 26% (P<0.001). The increase in ghrelin AUC correlated significantly with improved estimated insulin sensitivity (WBISI) (r=0.69, P<0.001). The independent predicting effect of WBISI was confirmed in multivariate analysis. In children with low WBISI, ghrelin reached the level of control values after weight loss. In children with high WBISI, ghrelin increased markedly above control levels. CONCLUSIONS: Changes in ghrelin are independently associated with changes in glucose and insulin metabolism. The increase in plasma ghrelin above control levels was limited to obese children with high WBISI. SN - 0307-0565 UR - https://www.unboundmedicine.com/medline/citation/16801928/Regulation_of_ghrelin_is_related_to_estimated_insulin_sensitivity_in_obese_children_ L2 - http://dx.doi.org/10.1038/sj.ijo.0803399 DB - PRIME DP - Unbound Medicine ER -