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Effects of a 5-HT(4) receptor agonist on oesophageal function and gastro-oesophageal reflux: studies using combined impedance-manometry and combined impedance-pH.
Aliment Pharmacol Ther 2006; 24(1):155-62AP

Abstract

BACKGROUND

5-HT(4) receptor agonists are used as promotility agents of the stomach, small and large intestine. There is limited information on the influence of 5-HT(4) receptor agonists on oesophageal function and gastro-oesophageal reflux.

AIM

To evaluate the effects of tegaserod, a 5-HT(4) agonist on oesophageal function using impedance-manometry and postprandial reflux using impedance-pH monitoring.

METHODS

Twenty healthy volunteers were enrolled in a double-blind randomized three-period crossover placebo-controlled study. Impedance-manometry and impedance-pH monitoring after a refluxogenic meal were performed at baseline and after 2 days of dosing with tegaserod 6 mg b.d. or placebo. Multichannel intraluminal impedance-EM recorded pressure and bolus transit data during standardized swallows. Multichannel intraluminal impedance-pH monitoring recorded the number of 2-h postprandial acid and non-acid reflux episodes.

RESULTS

We found no significant difference in distal oesophageal amplitude when subjects received placebo (median 94.5; range: 53-243 mmHg) or tegaserod (93.6; 43-216 mmHg). Bolus transit time was similar during dosing with placebo (7.1; 5.3-9.4 s) and tegaserod (7.2; 5.9-11.1 s). We observed similar numbers of acid and non-acid reflux episodes during dosing with placebo (5; 0-15 and 3; 0-18, respectively) and tegaserod (2; 0-11 and 4; 0-19, respectively).

CONCLUSION

Tegaserod, a 5-HT(4) receptor agonist does not change oesophageal motility and gastro-oesophageal reflux parameters in healthy volunteers.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, SC 29425, USA. tutuianr@musc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16803614

Citation

Tutuian, R, et al. "Effects of a 5-HT(4) Receptor Agonist On Oesophageal Function and Gastro-oesophageal Reflux: Studies Using Combined Impedance-manometry and Combined Impedance-pH." Alimentary Pharmacology & Therapeutics, vol. 24, no. 1, 2006, pp. 155-62.
Tutuian R, Mainie I, Allan R, et al. Effects of a 5-HT(4) receptor agonist on oesophageal function and gastro-oesophageal reflux: studies using combined impedance-manometry and combined impedance-pH. Aliment Pharmacol Ther. 2006;24(1):155-62.
Tutuian, R., Mainie, I., Allan, R., Hargreaves, K., Agrawal, A., Freeman, J., ... Castell, D. O. (2006). Effects of a 5-HT(4) receptor agonist on oesophageal function and gastro-oesophageal reflux: studies using combined impedance-manometry and combined impedance-pH. Alimentary Pharmacology & Therapeutics, 24(1), pp. 155-62.
Tutuian R, et al. Effects of a 5-HT(4) Receptor Agonist On Oesophageal Function and Gastro-oesophageal Reflux: Studies Using Combined Impedance-manometry and Combined Impedance-pH. Aliment Pharmacol Ther. 2006 Jul 1;24(1):155-62. PubMed PMID: 16803614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a 5-HT(4) receptor agonist on oesophageal function and gastro-oesophageal reflux: studies using combined impedance-manometry and combined impedance-pH. AU - Tutuian,R, AU - Mainie,I, AU - Allan,R, AU - Hargreaves,K, AU - Agrawal,A, AU - Freeman,J, AU - Gale,J, AU - Castell,D O, PY - 2006/6/29/pubmed PY - 2007/1/19/medline PY - 2006/6/29/entrez SP - 155 EP - 62 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 24 IS - 1 N2 - BACKGROUND: 5-HT(4) receptor agonists are used as promotility agents of the stomach, small and large intestine. There is limited information on the influence of 5-HT(4) receptor agonists on oesophageal function and gastro-oesophageal reflux. AIM: To evaluate the effects of tegaserod, a 5-HT(4) agonist on oesophageal function using impedance-manometry and postprandial reflux using impedance-pH monitoring. METHODS: Twenty healthy volunteers were enrolled in a double-blind randomized three-period crossover placebo-controlled study. Impedance-manometry and impedance-pH monitoring after a refluxogenic meal were performed at baseline and after 2 days of dosing with tegaserod 6 mg b.d. or placebo. Multichannel intraluminal impedance-EM recorded pressure and bolus transit data during standardized swallows. Multichannel intraluminal impedance-pH monitoring recorded the number of 2-h postprandial acid and non-acid reflux episodes. RESULTS: We found no significant difference in distal oesophageal amplitude when subjects received placebo (median 94.5; range: 53-243 mmHg) or tegaserod (93.6; 43-216 mmHg). Bolus transit time was similar during dosing with placebo (7.1; 5.3-9.4 s) and tegaserod (7.2; 5.9-11.1 s). We observed similar numbers of acid and non-acid reflux episodes during dosing with placebo (5; 0-15 and 3; 0-18, respectively) and tegaserod (2; 0-11 and 4; 0-19, respectively). CONCLUSION: Tegaserod, a 5-HT(4) receptor agonist does not change oesophageal motility and gastro-oesophageal reflux parameters in healthy volunteers. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/16803614/Effects_of_a_5_HT_4__receptor_agonist_on_oesophageal_function_and_gastro_oesophageal_reflux:_studies_using_combined_impedance_manometry_and_combined_impedance_pH_ L2 - https://doi.org/10.1111/j.1365-2036.2006.02968.x DB - PRIME DP - Unbound Medicine ER -