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Evaluation of the effect of gain on the meal response of an automated closed-loop insulin delivery system.
Diabetes. 2006 Jul; 55(7):1995-2000.D

Abstract

A continuous closed-loop insulin delivery system using subcutaneous insulin delivery was evaluated in eight diabetic canines. Continuous glucose profiles were obtained by extrapolation of blood glucose measurements. Insulin delivery rate was calculated, using a model of beta-cell insulin secretion, and delivered with a Medtronic MiniMed subcutaneous infusion pump. The model acts like a classic proportional-integral-derivative controller, delivering insulin in proportion to glucose above target, history of past glucose values, and glucose rate of change. For each dog, a proportional gain was set relative to the open-loop total daily dose (TDD) of insulin. Additional gains based on 0.5 x TDD and 1.5 x TDD were also evaluated (gain dose response). Control was initiated 4 h before the meal with a target of 6.7 mmol/l. At the time of the meal, glucose was similar for all three gains (6.0 +/- 0.3, 5.2 +/- 0.3, and 4.9 +/- 0.5 mmol/l for 0.5 x TDD, TDD, and 1.5 x TDD, respectively; P > 0.05) with near-target values restored at the end of experiments (8.2 +/- 0.9, 6.0 +/- 0.6, and 6.0 +/- 0.5, respectively). The peak postprandial glucose level decreased significantly with increasing gain (12.1 +/- 0.6, 9.6 +/- 1.0, and 8.5 +/- 0.6 mmol/l, respectively; P < 0.05). The data demonstrate that closed-loop insulin delivery using the subcutaneous site can provide stable glycemic control within a range of gain.

Authors+Show Affiliations

Medtronic MiniMed, 18000 Devonshire Rd., Northridge, CA 91325, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16804068

Citation

Panteleon, Antonios E., et al. "Evaluation of the Effect of Gain On the Meal Response of an Automated Closed-loop Insulin Delivery System." Diabetes, vol. 55, no. 7, 2006, pp. 1995-2000.
Panteleon AE, Loutseiko M, Steil GM, et al. Evaluation of the effect of gain on the meal response of an automated closed-loop insulin delivery system. Diabetes. 2006;55(7):1995-2000.
Panteleon, A. E., Loutseiko, M., Steil, G. M., & Rebrin, K. (2006). Evaluation of the effect of gain on the meal response of an automated closed-loop insulin delivery system. Diabetes, 55(7), 1995-2000.
Panteleon AE, et al. Evaluation of the Effect of Gain On the Meal Response of an Automated Closed-loop Insulin Delivery System. Diabetes. 2006;55(7):1995-2000. PubMed PMID: 16804068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the effect of gain on the meal response of an automated closed-loop insulin delivery system. AU - Panteleon,Antonios E, AU - Loutseiko,Mikhail, AU - Steil,Garry M, AU - Rebrin,Kerstin, PY - 2006/6/29/pubmed PY - 2006/8/15/medline PY - 2006/6/29/entrez SP - 1995 EP - 2000 JF - Diabetes JO - Diabetes VL - 55 IS - 7 N2 - A continuous closed-loop insulin delivery system using subcutaneous insulin delivery was evaluated in eight diabetic canines. Continuous glucose profiles were obtained by extrapolation of blood glucose measurements. Insulin delivery rate was calculated, using a model of beta-cell insulin secretion, and delivered with a Medtronic MiniMed subcutaneous infusion pump. The model acts like a classic proportional-integral-derivative controller, delivering insulin in proportion to glucose above target, history of past glucose values, and glucose rate of change. For each dog, a proportional gain was set relative to the open-loop total daily dose (TDD) of insulin. Additional gains based on 0.5 x TDD and 1.5 x TDD were also evaluated (gain dose response). Control was initiated 4 h before the meal with a target of 6.7 mmol/l. At the time of the meal, glucose was similar for all three gains (6.0 +/- 0.3, 5.2 +/- 0.3, and 4.9 +/- 0.5 mmol/l for 0.5 x TDD, TDD, and 1.5 x TDD, respectively; P > 0.05) with near-target values restored at the end of experiments (8.2 +/- 0.9, 6.0 +/- 0.6, and 6.0 +/- 0.5, respectively). The peak postprandial glucose level decreased significantly with increasing gain (12.1 +/- 0.6, 9.6 +/- 1.0, and 8.5 +/- 0.6 mmol/l, respectively; P < 0.05). The data demonstrate that closed-loop insulin delivery using the subcutaneous site can provide stable glycemic control within a range of gain. SN - 0012-1797 UR - https://www.unboundmedicine.com/medline/citation/16804068/Evaluation_of_the_effect_of_gain_on_the_meal_response_of_an_automated_closed_loop_insulin_delivery_system_ L2 - https://diabetes.diabetesjournals.org/lookup/pmidlookup?view=long&amp;pmid=16804068 DB - PRIME DP - Unbound Medicine ER -