Tags

Type your tag names separated by a space and hit enter

Analysis of bone mineral density and turnover in patients with cystic fibrosis: associations between the IGF system and inflammatory cytokines.
Horm Res. 2006; 66(4):162-8.HR

Abstract

BACKGROUND

Cystic fibrosis (CF) patients present an increased risk of osteoporosis, and increased fracture rate. Several factors have been identified as modulators of bone metabolism and bone mineral density (BMD).

AIMS

To evaluate BMD and serum markers of bone turnover and establish their relationships with serum concentrations of interleukin (IL)-1beta, IL-6, tumour necrosis factor (TNF)-alpha, IGF-I, IGF-II, IGF binding protein (IGFBP)-2, IGFBP-3, and parathyroid hormone (PTH) in young adult CF patients.

METHODS

Seventeen young adult CF patients (4 M, 13 F; mean age: 26.6 +/- 1.1 years) were enrolled in the study and analysed as a whole and as two subgroups according to the Shwachman-Kulczycki score. BMD was assessed at the lumbar spine (L1-L4) by dual energy X-ray absorptiometry (DXA Hologic QDR 2000). Bone turnover was assessed by measuring serum levels of osteocalcin (OC) and serum carboxyterminal propeptide of type I collagen (PICP) as markers of bone formation, and serum cross-linked carboxyterminal telopeptide of type I collagen (ICTP) as a marker of bone resorption. Serum IGFs, IGFBPs, and cytokines were assayed using special commercial kits. Daily calcium intake and weekly physical activity were estimated by questionnaires. Forced expiratory volume in one second was used to assess pulmonary function.

RESULTS

Lumbar BMD was normal, although there was a tendency to be lower in the patients with a lower clinical score. Both OC and PICP were increased, whereas ICTP was normal. Lumbar BMD was positively correlated with pulmonary function. IL-6 and C-reactive protein (markers of inflammation) were inversely correlated with PICP. Serum ICTP levels were correlated with serum IGF-I levels. No significant relationship was detected among lumbar BMD, markers of bone turnover and PTH, IGF-I, IGF-II, IGFBP-2, IGFBP-3, TNF-alpha, IL-1beta, and body mass index Z-score.

CONCLUSIONS

Bone turnover is abnormal in CF patients. Young adult CF patients with satisfying clinical status and nutritional conditions have normal BMD and increased serum OC and PICP levels.

Authors+Show Affiliations

Department of Pediatrics, University of Parma, Parma, Italy. mariaelisabeth.street@unipr.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16804317

Citation

Street, Maria E., et al. "Analysis of Bone Mineral Density and Turnover in Patients With Cystic Fibrosis: Associations Between the IGF System and Inflammatory Cytokines." Hormone Research, vol. 66, no. 4, 2006, pp. 162-8.
Street ME, Spaggiari C, Ziveri MA, et al. Analysis of bone mineral density and turnover in patients with cystic fibrosis: associations between the IGF system and inflammatory cytokines. Horm Res. 2006;66(4):162-8.
Street, M. E., Spaggiari, C., Ziveri, M. A., Volta, C., Federico, G., Baroncelli, G. I., Bernasconi, S., & Saggese, G. (2006). Analysis of bone mineral density and turnover in patients with cystic fibrosis: associations between the IGF system and inflammatory cytokines. Hormone Research, 66(4), 162-8.
Street ME, et al. Analysis of Bone Mineral Density and Turnover in Patients With Cystic Fibrosis: Associations Between the IGF System and Inflammatory Cytokines. Horm Res. 2006;66(4):162-8. PubMed PMID: 16804317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of bone mineral density and turnover in patients with cystic fibrosis: associations between the IGF system and inflammatory cytokines. AU - Street,Maria E, AU - Spaggiari,Cinzia, AU - Ziveri,Maria A, AU - Volta,Cecilia, AU - Federico,Giovanni, AU - Baroncelli,Giampiero I, AU - Bernasconi,Sergio, AU - Saggese,Giuseppe, Y1 - 2006/06/23/ PY - 2006/01/19/received PY - 2006/05/15/accepted PY - 2006/6/29/pubmed PY - 2006/12/9/medline PY - 2006/6/29/entrez SP - 162 EP - 8 JF - Hormone research JO - Horm. Res. VL - 66 IS - 4 N2 - BACKGROUND: Cystic fibrosis (CF) patients present an increased risk of osteoporosis, and increased fracture rate. Several factors have been identified as modulators of bone metabolism and bone mineral density (BMD). AIMS: To evaluate BMD and serum markers of bone turnover and establish their relationships with serum concentrations of interleukin (IL)-1beta, IL-6, tumour necrosis factor (TNF)-alpha, IGF-I, IGF-II, IGF binding protein (IGFBP)-2, IGFBP-3, and parathyroid hormone (PTH) in young adult CF patients. METHODS: Seventeen young adult CF patients (4 M, 13 F; mean age: 26.6 +/- 1.1 years) were enrolled in the study and analysed as a whole and as two subgroups according to the Shwachman-Kulczycki score. BMD was assessed at the lumbar spine (L1-L4) by dual energy X-ray absorptiometry (DXA Hologic QDR 2000). Bone turnover was assessed by measuring serum levels of osteocalcin (OC) and serum carboxyterminal propeptide of type I collagen (PICP) as markers of bone formation, and serum cross-linked carboxyterminal telopeptide of type I collagen (ICTP) as a marker of bone resorption. Serum IGFs, IGFBPs, and cytokines were assayed using special commercial kits. Daily calcium intake and weekly physical activity were estimated by questionnaires. Forced expiratory volume in one second was used to assess pulmonary function. RESULTS: Lumbar BMD was normal, although there was a tendency to be lower in the patients with a lower clinical score. Both OC and PICP were increased, whereas ICTP was normal. Lumbar BMD was positively correlated with pulmonary function. IL-6 and C-reactive protein (markers of inflammation) were inversely correlated with PICP. Serum ICTP levels were correlated with serum IGF-I levels. No significant relationship was detected among lumbar BMD, markers of bone turnover and PTH, IGF-I, IGF-II, IGFBP-2, IGFBP-3, TNF-alpha, IL-1beta, and body mass index Z-score. CONCLUSIONS: Bone turnover is abnormal in CF patients. Young adult CF patients with satisfying clinical status and nutritional conditions have normal BMD and increased serum OC and PICP levels. SN - 0301-0163 UR - https://www.unboundmedicine.com/medline/citation/16804317/Analysis_of_bone_mineral_density_and_turnover_in_patients_with_cystic_fibrosis:_associations_between_the_IGF_system_and_inflammatory_cytokines_ L2 - https://www.karger.com?DOI=10.1159/000094143 DB - PRIME DP - Unbound Medicine ER -