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Does striatal pathology distinguish Parkinson disease with dementia and dementia with Lewy bodies?
Acta Neuropathol. 2006 Sep; 112(3):253-60.AN

Abstract

The morphological differentiation of Parkinson disease with dementia (PDD) and dementia with Lewy bodies (DLB) is a matter of discussion. The objective of this study was to investigate the regional distribution of beta-amyloid (Abeta) plaques, alpha-synuclein (AS), and pathology in both disorders. The basal ganglia from 17 age-matched patients of PDD and DLB each were immunohistochemically examined with variable degrees of associated Alzheimer pathology using antibodies to Abeta, AS, and tau. DLB brains showed a significantly higher burden of (diffuse) amyloid plaques in the putamen and caudate nucleus and slightly more severe tau pathology than PDD brains despite similar neuritic Braak stages. Phases of Abeta development in DLB brains often, but inconsistently, correlated with both neuritic Braak stages and severity of striatal Abeta load, while these correlations were almost never seen in PDD cases with Alzheimer lesions. They also revealed a higher burden of AS-lesions (both Lewy neurites and Lewy bodies) than PDD cases that commonly had a paucity of all three types of lesion. The globus pallidus was virtually spared in both phenotypes. Differences in AS and Abeta pathologies and much less of tau lesions in the striatum support a morphologic distinction between PDD and DLB, which may be of pathophysiologic importance, but the causes of these differences are unclear.

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Authors+Show Affiliations

Jellinger KA
Institute of Clinical Neurobiology, Kenyongasse 18, 1070 Vienna, Austria. kurt.jellinger@univie.ac.at
Attems J
No affiliation info available

MeSH

AgedAged, 80 and overBasal GangliaDementiaDiagnosis, DifferentialDisease ProgressionFemaleHumansLewy Body DiseaseLimbic SystemMaleNeostriatumParkinson DiseasePhenotypePlaque, Amyloid

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16804711

Citation

Jellinger, Kurt A., and Johannes Attems. "Does Striatal Pathology Distinguish Parkinson Disease With Dementia and Dementia With Lewy Bodies?" Acta Neuropathologica, vol. 112, no. 3, 2006, pp. 253-60.
Jellinger KA, Attems J. Does striatal pathology distinguish Parkinson disease with dementia and dementia with Lewy bodies? Acta Neuropathol. 2006;112(3):253-60.
Jellinger, K. A., & Attems, J. (2006). Does striatal pathology distinguish Parkinson disease with dementia and dementia with Lewy bodies? Acta Neuropathologica, 112(3), 253-60.
Jellinger KA, Attems J. Does Striatal Pathology Distinguish Parkinson Disease With Dementia and Dementia With Lewy Bodies. Acta Neuropathol. 2006;112(3):253-60. PubMed PMID: 16804711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does striatal pathology distinguish Parkinson disease with dementia and dementia with Lewy bodies? AU - Jellinger,Kurt A, AU - Attems,Johannes, Y1 - 2006/06/28/ PY - 2006/04/21/received PY - 2006/05/17/accepted PY - 2006/05/17/revised PY - 2006/6/29/pubmed PY - 2007/2/9/medline PY - 2006/6/29/entrez SP - 253 EP - 60 JF - Acta neuropathologica JO - Acta Neuropathol VL - 112 IS - 3 N2 - The morphological differentiation of Parkinson disease with dementia (PDD) and dementia with Lewy bodies (DLB) is a matter of discussion. The objective of this study was to investigate the regional distribution of beta-amyloid (Abeta) plaques, alpha-synuclein (AS), and pathology in both disorders. The basal ganglia from 17 age-matched patients of PDD and DLB each were immunohistochemically examined with variable degrees of associated Alzheimer pathology using antibodies to Abeta, AS, and tau. DLB brains showed a significantly higher burden of (diffuse) amyloid plaques in the putamen and caudate nucleus and slightly more severe tau pathology than PDD brains despite similar neuritic Braak stages. Phases of Abeta development in DLB brains often, but inconsistently, correlated with both neuritic Braak stages and severity of striatal Abeta load, while these correlations were almost never seen in PDD cases with Alzheimer lesions. They also revealed a higher burden of AS-lesions (both Lewy neurites and Lewy bodies) than PDD cases that commonly had a paucity of all three types of lesion. The globus pallidus was virtually spared in both phenotypes. Differences in AS and Abeta pathologies and much less of tau lesions in the striatum support a morphologic distinction between PDD and DLB, which may be of pathophysiologic importance, but the causes of these differences are unclear. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/16804711/Does_striatal_pathology_distinguish_Parkinson_disease_with_dementia_and_dementia_with_Lewy_bodies L2 - https://dx.doi.org/10.1007/s00401-006-0088-2 DB - PRIME DP - Unbound Medicine ER -